Term
| Prochlorperazine, triflupromazine, chlorpromazine, trifluoperazine are phenothiazine antipsychotics, ctonrol vomiting by blocking D2 receptors in chemoreceptor trigger zone of brainstem |
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Definition
| Prochlorperazine (Compazine) |
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Term
| D2 dop antagonist & H1 antagonist used to conrol motion sickness & N/V, esp following surgery reduces anesthesia-related nausea |
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Definition
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Term
| D2 antagonist for reducing chemo-induced nausea & GI stim to improve gastric emptying |
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Definition
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Term
| anticholinergic as transdermal prep to prevent motion sickness |
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Definition
| Scopolamine (Transderm Scop) |
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Term
| Diphenhydramine, dimenhydrinate, meclizine antihistamines c anticholinergic effects reduce motion sickness & emesis |
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Definition
| Anticholinergics/antihistamines |
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Term
| Blocks serotonin (5-HT3) receptors, but not dop receptors- control chemo-induced nausea |
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Definition
| Ondansetron (Zofran), Granisetron (Kytril), Dolastetron (Anzemet) |
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Term
| Tx tonic clonic & partial seizures |
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Definition
| Carbamazepine, phenytoin, primidone, valproic acid |
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Term
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Definition
| Ethosuximide, valproic acid, clonazepam |
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Term
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Definition
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Term
| oxazolidimedione anticonvulsant- resistant epilepsy |
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Definition
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Term
| Block voltage-gated Na channels in neuronal membranes & prolong nueronal refractory period; nystagmus, diplopia, ataxia; S/E bld dyscrasias (trig neuralgia), skin rash |
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Definition
| Carbamazepine (Tegretol), phenytoin (Dilantin) |
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Term
| Structural analog of phenobarbital, converted to phenobarbital; drowsiness early esp inc dose |
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Definition
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Term
| Blocks Na channels, prolong nuer refractory (high dose); inhibits T-type Ca channels, in thalamus, enhance, K, inhibit GAT-1, S/E hepatotoxicity tx L-carnitine; blocks NMDA rec-med excitation, inc GABA via GAD, dec GAT-1 |
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Definition
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Term
| Allosterically mod GABA action, inc freq of Cl influx & hyperpolarizes neurons |
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Definition
| Clonazepam (Klonopen), Diazepam (Valium), Lorazepam (Ativan) |
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Term
| use-dep block of NMDA receptor c selectivity for NR1-2B subtype |
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Definition
| Feibamate, gabapentin (neurontin) |
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Term
| Blocks Na channels , Ca channels for absence attacks, focal epilepsy, dec synaptic release of glutamate |
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Definition
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Term
| Blocks Na channels, antagonist of Glu receptors |
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Definition
| Phenobarbital (Luminal sodium) |
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Term
| Inhibits GAT-1, inc GABA in neurons & glia, inc extracell GABA in forebrain & hippocampus |
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Definition
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Term
| Antagonist of Glu receptors, block Na channels and potentiate GABA; substituted monosaccharide; acute myopia, glaucoma, kidney stones, teratogenic, hypospadias |
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Definition
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Term
| AA analog of GABA for partial seizures |
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Definition
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Term
| GABA analog, also analgesic |
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Definition
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Term
| Binds selectively to synaptic vesicular protein SV2A |
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Definition
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