Term
|
Definition
1. NSAIDs
2. Stress
3. H pylori |
|
|
Term
|
Definition
| irreversibly binds to the H pump on the parietal cells; all p-ways for acid secretion are blocked |
|
|
Term
|
Definition
| reversbily binds H2 receptor |
|
|
Term
| first line tx in PUD & duration |
|
Definition
|
|
Term
|
Definition
|
|
Term
| 6 tx methods for tx resistant PUD |
|
Definition
1. increase strength of PPI
2. increase dose from 1 to 2xD
3. switch to different PPI
4. DC PPI start H2
5. add sucralfate
6. if NSAID induced add misoprostol |
|
|
Term
|
Definition
1. HA
2. D
3. abd pain
4. flatulence
5. constipation
6. rash |
|
|
Term
| PPI with most/least CYP interactions |
|
Definition
most = omeprazole
least - pantopazole |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| H2 w no CYP interactions; |
|
Definition
|
|
Term
| H2 with most CYP interaction: |
|
Definition
|
|
Term
|
Definition
1. constipation
2. D
3. dizzy
4. bradycardia |
|
|
Term
| first line tx for H pylori: |
|
Definition
| 3 drug combo: PPI+clarithromycin+Amox for 10-14days |
|
|
Term
| indication for 2nd line H pylori tx: |
|
Definition
| fail first line after 10-14d |
|
|
Term
| define secondline H pylori tx: |
|
Definition
| 4 drug combo: PPI or H2 +bismuth+ Metronidazole (or amox or clinda) + tetracycline for 10-14d |
|
|
