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Pharm-Nucleic acid synth inhiitors
na
26
Pharmacology
Post-Graduate
08/06/2010

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Cards

Term
Quinilones are mainly active against gram __ bacteria
Definition
negative
Term
____ is the first member of the quinolone group
Definition
Naidixic acid
Term
Quinolones act by ihibiting ______
Definition
DNA gyrase (topoisomease II)
Term
An important ADE of the quinolone nalidixic acid is___
Definition
Hemolysis in G-6-P deficiency
Term
Which of the nucleic acid synthesis inhibitos shows hemolysis in G6P Deficiency?
Definition
Nalidixic acid (Quinolone)
Term
Fluroquinolones end in the suffix ____
Definition
FLOXACIN
Term
What are the important effects of Fluorquinolones?
Definition
Bactericidal, Concentration dependent bacterial killing, Postantibiotic effect
Term
What is the mechanism of fluoroquinolones?
Definition
Inhibit bacterial DNA gyrase
Term
How do fluoroquinolones destribut to tissues like bone, prostate, and phagocytes?
Definition
Well
Term
What is the drug of choice for treating anthrax
Definition
Ciprofloxacin
Term
Norfloxacin is approved only to treat?
Definition
UTIs
Term
Which drug is used as prophylaxis against Pseudomonas in children with cytic fibrosis?
Definition
Ciprofloxacin
Term
The new FQs Levo/Gemi/Moxifloxacin are used to treat mainly_____ infections and have improved actvity against gram ___ bacteria
Definition
Respiratory, positive
Term
____ is the FQ thatis active against most betalactam and aminoglycoside resistant organisms
Definition
Cipofloxacin
Term
Is Ciprofloxacin Bacteriostatic or Bactericidal?
Definition
BACTERICIDAL
Term
Name 5 antibiotics which can be used to treat TYPHOID fever
Definition
Ciproflxacin, Levofloxacin, Ceftriaxone, Azithromycin, sulfamethoxazole-trimethoprim
Term
Which Nucleic acid synthsis inhibitors can present withthe following ADEs?
GI ditress rashes, CNS, Cartilage Damage, Tendonitis, QTc prolongation and Phototoxicity
Definition
Fluoroquinolones
Term
Along with the Fluoroquinolones _____ can also cause phootoxicity
Definition
Tetracyclines
Term
_____ enhance the CNS toxicity of Fluoroquinolones
Definition
NSAIDs
Term
All sulfonamides are synthetic analogs of ____.
Definition
PABA (paraaminobenzoic acid)
Term
Sulfonamides inhibit the formation of ____ by the enzyme dihydropteroat synthase
Definition
dihydrofolic acid
Term
Trimehoprim inhibits the formatn of _____ by the enzyme dihydrofolate reductase
Definition
Tetrahydrofolic acid
Term
In the plasma sulfonamides are ____ they are metabolized by ____ in the liver. They are widely distributed in the body including the ___.
Definition
protein bound, acetylation, CSF
Term
Cotrimazole or ___ is the combination of ___ & ____.
Definition
Bactrim, Trimethopim, Sulfamethoxazole
Term
The sulfonamide ___ is typically used topically
Definition
Silver Sulfadiazine
Term
The sulfonamide ____ is used in ulcerative colitis and rheumatoid arthritis
Definition
Sulfasalazine
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