Term
| mech of action for levodopa |
|
Definition
precursor in synthesis of DA
**crosses BBB** |
|
|
Term
| effect of food on levodopa |
|
Definition
| meals delay absorption and reduces plasma concentration |
|
|
Term
|
Definition
|
|
Term
| This inhibits AAD in the periphery |
|
Definition
carbidopa
**does NOT cross BBB** |
|
|
Term
| what is the on/off phenomenon |
|
Definition
| pts motor state fluctuates with each dose turning them back to the off phase until increase in dose happens, which can dysinesias |
|
|
Term
|
Definition
nausea and vomiting, cardiac issues ( peripheral DA)
confusion and hallucination in elderly
possible production of free radicals |
|
|
Term
| this should be discontinued 14 days before giving levodopa |
|
Definition
non-specific MAO inhibitors
**can cause hypertensive crisis** |
|
|
Term
| this co-factor in AAD activity must be monitored |
|
Definition
|
|
Term
|
Definition
bromocryptine
pergolide
pramipexole
ropinirole |
|
|
Term
| These drugs have selectivity at the D2 receptors |
|
Definition
| pramipexole and ropinirole |
|
|
Term
| which has longer half life: direct dopa ags or levodopa |
|
Definition
|
|
Term
| side effects pramipexole and ropinirole |
|
Definition
| somnolence, nausea, hallucinations |
|
|
Term
| indication for pramipexole and ropinrole |
|
Definition
used ALONE as initial treatment
especially in younger patients |
|
|
Term
|
Definition
| last result due to emetic properties |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| mech of action for COMT inhibs |
|
Definition
| block peripheral conversion of levodopa to 3-O methyldopa **INCREASING** levodopa half life |
|
|
Term
| comt inhib assoc w/hepatoxicity |
|
Definition
|
|
Term
|
Definition
| seleginline and rasagiline |
|
|
Term
| mech of action for MAO B inhibs |
|
Definition
neuroprotective properties
retards metabolism of DA |
|
|
Term
| MAO B inhib that forms amphetamine and meth |
|
Definition
|
|
