Immunosuppressant

Mech: binds cyclophilins → complex inhibs calcineurin → prevents production of IL-2 & its R → blocks differ. & activation of T-cells

Use: Organ Transplant, Autoimmune disorders

Tox: incr. risk viral infxn & lymphoma; nephrotoxic (prevent w/ mannitol diuresis)

Immunosuppressant (AKA: FK506)

Mech: binds FK-binding prot → inhibs IL-2 & CK secr

Use: Organ transplant - potent immunosuppression

Tox: nephrotox, periph neuropathy, HTN, hyperglycemia

Immunosuppressant

Mech: converted to 6-MP → blocks nucleic acid synth → toxic to proliferating lymphs

Use: kidney transpl; AI (GN, hemolytic anemia)

Tox: marrow suppr; toxicity incr. by allopurinol (6-MP is metab by XO)

Immunosuppressant (AKA: OKT3)

Mech: MAb vs CD3 on T cells → blocks T cell signal transduction

Use: kidney transplant

Tox: CK release synd, hypersens

Immunosuppressant (AKA: rapamycin)

Mech: binds mTOR → inhibs T-cell prolif in resp to IL-2

Use: kidney transp

Tox: hyperlipidemia, thrombocytopenia, leukopenia

Immunosuppressant

Mech: inhibs de novo guanine synth → blocks lymphocyte production

Immunosuppressant

Mech: MAb vs. IL-2 R on activated T cells

IL-2

Use: RCC, metastatic melanoma

G-CSF (granulocyte - Colony Stimulating Factor)

Use: marrow recovery

filGraSTIM

GM-CSF (Granulocyte Macrophage Colony Stim Factor)

Use: marrow recovery

sarGraMoSTIM

IL-11

Use: thrombocytopenia

Stim Megakaryocyte prod.