pre-dopamine substrate

dopa mimetic

neurodegenerative diseases

dopa mimetic - cholinergic receptor antagonist

enhances existing dopa

parkinsons

inhibits MAO-B

parkinsons

inhibits COMT (dopa metabolism)

parkinsons

inhibits COMT (dopa metabolism)

parkinsons

D1 and D2 agonist (ergot)

parkinsons

D2 agonist

parkinsons

D2 agonist

parkinsons

D2 agonist

parkinsons

D-agonists for off episodes (non ergot)

parkinsons

antimuscarinic

block excitatory M-receptors, restore balance w/ DOPA

alzheimers

anti-muscarinic

block excitatory M receptors, restore balance w/ DOPA

alzheimers

anti-muscarinic

block excitatory M receptors, restore balance w/ DOPA

alzheimers

NMDA antagonist

Alzheimers

NMDA antagonist

alzheimers

AchE inhibitors (specifically in CNS)

alzheimers

rivastigmine

AchE inhibitors (specifically in CNS)

alzheimers

AchE inhibitors (specifically in CNS)

alzheimers

AchE inhibitors (specifically in CNS)

alzheimers

hyperpolarize mu > delta, kappa >> sigma

strong agonist

Narcotic

kappa > others

strong agonist

narcotic

less mu than morphine

strong agonist

narcotic

opiod agonist (strong)

narcotic

acetylated morphine

strong agonist

narcotic

moderate opiod agonist

narcotic

moderate opiod agonist

narcotic

mixed agonist

Kappa agonist, mu/sigma antagonist

narcotic

mixed agonist

partial mu agonist

narcotic

mixed agonist

kappa partial agonist 

narcotic

mu > kappa, sigma opiod antagonist

narcotic

mu > kappa, sigma opiod antagonist

narcotic

increase sensitivity to GABA receptors

inhalation

anesthetic

increase sensitivity to GABA receptors

inhalation

anesthetic

increase sensitivity to GABA receptors

inhalation

anesthetic

increase sensitivity to GABA receptors

inhalation

anesthetic

increase sensitivity to GABA receptors

inhalation

anesthetic

barbiturates

(thiopental, thiamylal)

GABA hyperpotentiators

intravenous

anesthetic

benzo

(ativan and versed)

GABA hyperpotentiators

intravenous

anesthetic

dopa blocker

IV

anesthetics

NMDA antagonist

IV

anesthetic

GABA hyperpotentiators

intravenous

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

Ester

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

inhibit Na+ channels of peripheral nerves, slowing depolarization

amide

anesthetic

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

D2 receptor competitive antagonist

typical, 1st generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

5HT receptor antagonist

atypical 2nd generation

neuroleptic

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

D2 blockers in CTZ of medulla

phenothiazines

neuroleptic

phosphodiesterase inhibitors- increase cAMP, cGMP and adenosine agonists

methylxanthines

stimulants

phosphodiesterase inhibitors- increase cAMP, cGMP and adenosine agonists

methylxanthines

stimulants

N receptor agonist

psychomotor 

stimulants

methylxanthine 

others (nicotine, cocaine, amphet, methylphenidate)

blocks Ne, serotonin, and dopa reuptake

psychomotor

stimulants

stimulates release of NE/dopa stores

psychomotor

stimulants

stimulates release of NE/dopa stores

psychomotor

stimulants

serotonin agonist

psychmimetic

stimulant

NMDA-receptor antagonist

psychomimetic

stimulant

blocks Na+ and Ca++ channels

anti-epileptic

Na+ channel blocker

anti-epileptic

GABa potentiator

anti-epileptic

GABA potentiator

anti-epileptic

blocks T-type Ca++ channels

anti-epileptic

allosteric GABA potentiation/hyperpolarization

BZ

anti-epileptic

allosteric GABA potentiation/hyperpolarization

BZ

anti-epileptic

NMDA, Na+, Ca++ blocker 

adjunct 

anti-epileptic

GABA analog, other receptor?

adjunct

anti-epileptic

Glut/Asp release inhibitor

adjunct

anti-epileptic

GABA reuptake inhibitor

adjunct

anti-epileptic

GABA pot, Na+ blocker, Ca++ blocker

adjunct

anti-epileptic

GABA pot, Na+ blocker, Ca ++ T-type blocker

adjunct

anti-epileptic

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

NE and serotonin reuptake inhibitors 

TCA 1st generation

antidepressants

NE and Sero reuptake inhibitors

TCA 2nd generation

antidepressants

NE and serotonin reuptake inhibitors 

TCA 2nd generation

antidepressants

selective inhibiton of serotonin reuptake

SSRI

antidepressants

cleaner inhibition of NE and 5HT reuptake 

SNRI 

antidepressants

cleaner inhibition of NE and 5HT reuptake 

SNRI 

antidepressants

5HT2 and alpha 2 antagonist

atypical

antidepressant

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

inhibit MAO breakdown of NE, 5HT, DA

MAOI

antidepressant

 inositol triphosphate

BPD

antidepresants

combination

BPD

antidepresants