Term
| travels through functional nervous system reporting potential or actual tissue injury |
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Definition
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Term
| thorugh dysfunctional nervous system reporting injury to nervous system |
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Definition
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Term
| natural and synthetic substances that produce morphine- like effects (entire class) |
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Definition
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Term
| term reserved for natural substances from opium poppy |
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Definition
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Term
| Opiods bind to opiod receptors in CNS to mimic.. |
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Definition
endogenous neurotransmitters
endorphins
enkephalins |
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Term
| Opiods hyerpolarize membranes thus... |
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Definition
inhibiting depolarization
decrease cAMP, increase K+ efflux, decrease Ca influx |
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Term
| Primary use of opiods is to |
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Definition
| relieve pain and the anxiety that accompaines pain |
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Term
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Definition
supraspinal analgesia
respiratory depression
euphoria/sedation
physical dependence
decreased GI motility
miosis |
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Term
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Definition
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Term
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Definition
| Mu > Delta, Kappa >> Sigma |
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Term
| MOA: Binds with opiod receptors in CNS and GI track and cause hyperpolarization of nerve cells |
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Definition
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Term
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Definition
analgesia
euphoria
anti-diarrheal
cough suppression
respiratory depression
tx of acute pulmonary edema
miosis
histamine release (bronchoconstriction) |
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Term
| AE: severe respiratory depression, vomiting, dysphoria, allergy-enhanced hypotensive effects, bronchospasm, constipation |
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Definition
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Term
| Biliary track - _____ constrict the sphincter of Oddi = increase biliary pressure |
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Definition
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Term
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Definition
| morphine because it causes urinary retention |
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Term
GI absorption is poor
IM, IV, or SQ better
metabolized by phase II elimination (glucuronidation) |
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Definition
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Term
| Neonates dont conjuage therefore, no... |
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Definition
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Term
| Analgesic tolerance develops faster than respiratory depression with what drug? |
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Definition
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Term
| Synthetic opiod NOT opiate |
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Definition
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Term
| Binds mu/kappa receptors > others |
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Definition
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Term
| Actions: respiratory depression, increased ICP, constipation, mydriasis |
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Definition
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Term
| watch for hypotension postop |
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Definition
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Term
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Definition
analgesia
extensive use in labor |
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Term
| N-demethylated in liver- Caution in dialysis patients because this drug could cause seizures |
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Definition
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Term
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Definition
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Term
| Actions: analgesia (equivalent to morphine), constipation, miosis, increased ICP, respiratory depression |
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Definition
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Term
| Analgesia 80 times > Morphine |
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Definition
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Term
| good for perioperative analgesia |
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Definition
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Term
| Fetanyl is used in neurolept anesthesia when combined with? |
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Definition
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Term
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Definition
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Term
3 times > potency than morphine
BBB crossed easily (great euphoria) |
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Definition
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Term
| Uses: analgesia, antitussive |
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Definition
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Term
Antitussive
Requires less than analgesic dose
being replaced by dextromethorphan |
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Definition
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Term
Mixed Agonist-Antagonists
No recent exposure = |
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Definition
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|
Term
Mixed Agonist-Antagonist
Recent/chronic exposure = |
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Definition
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Term
Kappa agonist, mu, and sigma antagonist
parenteral or PO
Caution in angina pt's |
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Definition
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|
Term
partial mu agonist
long duration |
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Definition
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Term
kappa agonist, partial mu agonist
nasal spray
can use in labor |
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Definition
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Term
| Antagonist at mu > kappa and sigma receptors |
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Definition
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Term
similar to naloxone
longer 1/2 life
rehab |
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Definition
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Term
| drug seeking, restlessness, lacrimation, rhinorrhea, sweating, yawning |
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Definition
| 6-12 hrs opiod withdrawal |
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Term
| irritability, tremor, dilated pupils, anorexia, piloerection |
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Definition
| 12-24 hrs opiod withdrawal |
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Term
| weakness, depression, N/V, abd cramps, diarrhea, chills/flushes, tachy, HTN, and dehydration |
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Definition
| 24-72 hrs opiod withdrawal |
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Term
alternating restless sleep
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Definition
| 7-10 days, opiod withdrawal |
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