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Pharm II Exam 3
DRUGS ONLY
106
Pharmacology
Graduate
06/07/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Morphine
Definition

Strong Opioid Agonist 

 

PROTOTYPE

Term
Meperidine (Demerol)
Definition
Strong Opioid Agonist
Term
Methadone (Symoron)
Definition
Strong Opioid Agonist
Term
Fentanyl (Actig, Duragesic)
Definition
Strong Opioid Agonist
Term
Heroin
Definition
Strong Opioid Agonist
Term
Codeine
Definition
Moderate Opoid Agonist
Term
Oxycodone (Oxycontin, Percoset)
Definition
Moderate Opoid Agonist
Term
Propoxyphene (Darvon, Darvocet)
Definition
Moderate Opoid Agonist
Term
Buprenorphine (Buprenex, Suboxone)
Definition
Mixed Opoid Agonist/Antagonist
Term
Nalbuphine (Nubain)
Definition
Mixed Opoid Agonist/Antagonist
Term
Naloxone (Narcan)
Definition
Opioid Antagonist

IV, IM
Term
Naltrexone (Revia)
Definition
Opioid Antagonist

PO
Term
Tramadol (Ultram)
Definition
Other analgesic
Term
Aspirin (ASA) PROTOTYPE
Definition
NSAID
Term
ibuprofen (advil, motrin)
Definition
NSAID (propionic acid derivative)
Term
naproxen (naprosyn, aleve)
Definition
NSAID (propionic acid derivative)
Term
Sulindac (Clinoril)
Definition
NSAID (acetic acid derivative)
Term
indomethacin (indocin)
Definition
NSAID (acetic acid derivative)
Term
piroxicam (feldene)
Definition
NSAID (oxicam derivative)
Term
meloxicam (mobic)
Definition
NSAID (oxicam derivative)
Term
ketorolac (toradol)
Definition
NSAID (heteroaryl acetic acid)

(IV)(IM)(PO)
Term
celecoxib (celebrex)
Definition
COX-2 inhibitors
Term
acetaminophen
Definition
Other analgesics
Term
Methotrexate (Trexall)
Definition
DMARD

(PO)(IV)(IM)
DHFR Inhibitor (immunosuppressive)
Term
Leflunomide (Arava)
Definition
DMARD

(PO)
DHOOH Inhibitor (pyradine synthesis)
Term
hydroxychloroquine (Plaquenil)
Definition
DMARD

(PO)
Dendritic TLR Inhibitor
Term
sulfasalazine (Azulfidine)
Definition
Sulfa DMARD

(PO)
Term
Infliximab (Remicade)
Definition
BIOLOGIC DMARD

(IV)
TNF-α inhibitor
Term
etanercept (Enbrel)
Definition
BIOLOGIC DMARD

(IV)
TNF-α inhibitor
Term
anakinra (Kineret)
Definition
BIOLOGIC DMARD

(SQ)
IL-1 antagonist
Term
indomethacin (Indocin)
Definition
NSAID for GOUT
Term
colchicine (Colcrys)
Definition
plant alkyloid FOR GOUT
Term
allopurinol (Zyloprim)
Definition
purine analog FOR GOUT
Term
probenecid, sulfinpyrazone
Definition
uricosuric agents FOR GOUT

(IV)
Term
Acyclovir (Zovirax)
Definition
PO, IV, Topical

(HSV, VZ, HZ)
Term
Valacyclovir (Valtrex)
Definition
PO

(HSV, VZ, HZ)
Term
Famciclovir (Famvir)
Definition
PO

(HSV, VZ, HZ)
Term
Penciclovir (Denavir)
Definition
Topical

(herpes labialis)
Term
Trifluridine (Viroptic)
Definition
Topical: Eye drops

(HSV keratoconjunctivitis, recurrent epithelial keratitis)
Term
Vidarabine (Vira-A)
Definition
Topical: Eye ointment

(HSV keratoconjunctivitis, recurrent epithelial keratitis)
Term
Idoxuridine (Herplex)
Definition
Topical: Eye drops

(HSV-1 Keratitis)
Term
Ganciclovir (Cytovene)
Definition
PO, IV, Patch

PROTOTYPE

(CMV retinitis/colitis/esophagitis)
Term
Valganciclovir (Valcyte)
Definition
PO, IV

(CMV**DOC)
Term
Cidofovir (Vistide)
Definition
IV

(Broad HSV, ganciclovir-R CMV)
Term
Fomivirsen (Vitravene)
Definition
IV (eyeball)

(CMV retinitis (AIDS))
Term
Foscarnet (Foscavir)
Definition
IV

(Last resort drug to treat all CMV and R-CMV)
Term
Amantadine (Symmetrel)
Definition
PO

RNA ANTIVIRAL (Influenza A)
Term
Rimantadine (Flumadine)
Definition
PO

RNA ANTIVIRAL (Influenza A)
Term
Oseltamivir (Tamiflu)
Definition
PO

Neuraminidase Inhibitors
(Influenza A or B)
Term
Zanamivir (Relenza)
Definition
Inhaled

Neuraminidase Inhibitors
(Influenza A or B)
Term
Palivizumab (Synagis)
Definition
IM
MIXED MOA RESP. INFECT ANTIVIRAL
(RSV)
Term
Ribavirin (Virazole)
Definition
PO, IV, inhaled
MIXED MOA RESP. INFECT ANTIVIRAL
( RSV [Hep C, Broad spectrum] )
Term
Rebetron
Definition
PO

ANTIVIRAL COMBO
(Hep C)
Term
Interferon (PEG-intron)
Definition
SQ, IV

(Hep B, C, HPV)
Term
Zidovudine (Retrovir, AZT)
Definition

NRTI

 

dose-limiting bone marrow suppression, anemia, neutropenia drug interaction w/ ganciclovir

Term
Zalcitabine (ddc) (HIVID)
Definition

NRTI

 

use in advance AIDS and in combo w/ AZT peripheral neuropathy

Term
Stavudine (d4T) (Zetit)
Definition

NRTI

 

peripheral neuropathy, pancreatitis, lactic acidosis cannot be used w/ AZT

Term
Abacavir
Definition

NRTI

 

rash, severe/fatal hypersensitivity rxn no bone marrow suppression

 

NOT ON OBJECTIVES FOR NRTI'S

 

Term
Lamivudine (3TC) (Epivir)
Definition

NRTI

 

minimal txicity sometimes w/ Hep B to prevent infection combivir = lamivudine + AZT (used in PEP)

Term
Trizivir
Definition

NRTI

 

 

combo drug of non-food dependent drugs

 

NOT ON OBJECTIVES FOR NRTI'S

Term
Didanosine (ddl) (HIVID)
Definition

NRTI

 

dose-limiting pancreatitis (can be fatal), peripheral neuropathy made w/ buffering agent to prevent HCL degredation

Term
Adefovir
Definition

NRTI

 

Hep B drug

 

requires L-carnitine supplementation nephrotoxic no bone marrow suppression

 

NOT ON OBJECTIVES FOR NRTI'S

Term
Tenofovir
Definition

NRTI

 

admosine nucleotide analog  / chain termination

 

pts who have failed on other HIV drugs slow resistance to drug

 

NOT ON OBJECTIVES FOR NRTI'S

Term
Emtricitabine
Definition

NRTI

 

cytidine neucleoside analog

 

skin hyperpigmentation of the soles and palms

 

NOT ON OBJECTIVES FOR NRTI'S

Term
Efavirenz (Sustiva)
Definition

NNRTI

 

DMMS inducer

 

penetrates CNS & causes CNS s/e no preggers

Term
Nevirapine (Viramune)
Definition

NNRTI

 

DMMS inducer

 

alternative to AZT prevention of transmission during preggers

Term
Etravirine (Intelence)
Definition

NNRTI

 

resistant HIV

 

NOT ON OBJECTIVES FOR NNRTI'S

Term
Delavirdine (Rescriptor)
Definition

NNRTI

 

DMMS inhibitor

 

NOT ON OBJECTIVES FOR NNRTI'S

Term
ritonavir (Norvir)
Definition

PI

 

potent drug, advanced disease strong inh of P450 good combo w/ saquiovir

Term
indinavir (Crixivan)
Definition

PI

 

causes kidney stones, crystalluria

Term
nelfinavir (Viracept)
Definition

PI

 

PEP with combivir, zidovudine, lamivudine maternal dose during labor to dec. baby getting HIC x 50%

Term

Saquinavir-H (Invirase)

 

NOT ON OBJECTIVES

Definition
PI only used w/ ritonavir hard tablet
Term

Saquinavir-S (Fortovase)

 

NOT ON OBJECTIVES

Definition
PI soft tablet
Term

Amprenavir (Agenerase)

 

NOT ON OBJECTIVES

Definition
PI
Term

Kaletra (lopinavir/ritonvir)

 

NOT ON OBJECTIVES

Definition
PI combo drug lipinavir + ritonavir
Term

Atazanavir (Reyataz)

 

NOT ON OBJECTIVES

Definition

PI

 

less inc in TG/chol, less liprodystrophy

Term
enfuvirtide (Fuzeon)
Definition
FI
Term
Raltegravir (Isentress)
Definition
Integrase Inhibitor
Term
aspirin (ASA)
Definition
Platelet Inhibitors COX-1, inhibit PG synthesis, block TXA2
Term
ticlopidigine (Ticlid)
Definition
Platelet Inhibitors

inhibits ADP, fibrinogen binding to platelets
Term
clopidogrel (Plavix)
Definition
Platelet Inhibitors

preferred drug, most widely used anti-platelet
Term
dipyridamole (Persantin)
Definition
Platelet Inhibitors

vasodilator, inc cAMP, dec platelet Ca
high-risk pts only
Term
Heparin
Definition
Thrombin inhibitor
Term
enoxaparin (Lovenox)
Definition
Thrombin inhibitor
Term
dalteparin (Fragmin)
Definition
Thrombin inhibitor
Term
protamine sulfate
Definition
Heparin Antidote
Term
warfarin (Coumadin)
Definition
Vitamin K antagonist
Term
dicumarol
Definition
Vitamin K antagonist
Term
vitamin K, fresh frozen plasma
Definition
Warfarin Antidote
Term
phytonadione (Mephyton)
Definition
Warfarin Antidote
Term
Streptokinase (Streptase)
Definition
Thrombolytic
Term
tissue plasminogen activator (t-PA) (Alteplase)
Definition
Thrombolytic
Term
aminocaproic acid (Amicar)
Definition
Coagulant

Plasminogen inhibitor
Term
thrombin (Thrombogen, Thrombostat)
Definition
Coagulant

Thrombin stimulator
Term
gelatin sponge (Gelfoam), film (Gelfilm), cellulose (Surgicel)
Definition
Surgical Coagulant
Term
amphotericin B (Fungizone)
Definition
IV

Broad spectrum, invasive/progressive potentially fatal fungal infections
Term
flucytosine (Ancobon)
Definition
(PO)

crytococcal meningitis, systemic crytococcal/candidal infections *used in combo w/ AmpB (synergism), resistance when used alone
Term
ketoconazole (Nizoral)
Definition
(PO) IMANDIAZOLE

mucocutaneous fungal infections
Term
fluconazole (Diflucan)
Definition
(PO) TRIAZOLE

coccidioidal meningitis**DOC, serious/systemic candidiasis
Term
itraconazole (Sporanox)
Definition
(PO)(IV) TRIAZOLE

broad spectrum, histoplasmosis, no CNS infections
Term
Caspofungin (cancidas)
Definition
(IV) ECHINOCANDINS

Aspergillus and candida only; candida esophagitis, invasive aspergillosis, R-amp B or itraconazole
Term
griseofulvin (Grifulvin, Gris-Peg)
Definition
(PO)

ringworm/tineas nail infections, dermatophytic
Term
nystatin (Mycostatin)
Definition
TOPICAL/SWISH & SPIT

candidiasis
Term
miconazole (Monistat, Micatin)
Definition
TOPICAL/SUPPOSITORY

IMADIAZOLE candidiasis, ringworm
Term
clotrimazole (Mycelex Troches, Lotrimin)
Definition
TOPICAL IMADIAZOLE

candidiasis
Term
Terbinafine (Lamisil)
Definition
TOPICAL SYNTHETIC ALLYLAMINE

dermatophytoses, onychomycoses**DOC, candida albicans
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