Antiseizures (dec. Na+ influx)

Tx:  tonic clonic and partial seizures, no elderly

Monitor: BP, vitals, CBC, liver fx tests, plasma levels of phenytoin

AdRx:  osteoperosis, cardiac dysarrhythmias, gingival hyperplasia, SJS

Antiseizures (limit Na+ influx)

Tx:  simple and complex partial seizures, ok preggers

AdRx:  hematologic abnormalities, SJS, GI upset

Tx:  of trigeminal neuralgia, bipolar (off label)

Antiseizures (block Na+ channels)

Tx:  partial seizures

AdRx:  hyponatremia, dec. birth control

Antiseizures (promotes GABA activity)

Tx:  primary/adjunct therapy for multiple seizure types in adults and children

AdRx:  alopecia, hepatotoxicity, birth defects, wt gain

Monitor:  liver enzymes, CBC with platelets and valproic levels

Tx:  dementia, agitation, persistant hiccups (off label)

Antiseizures (reduces presynaptic GABA release)

Tx:  adjunct for complex partial seizures, good for elderly

No drug interactions

Tx:  pain with shingles, bipolar, essential tremor, migraines, neurotoxic pain syndrome (sciatica), hot flashes, phantom limb, restless leg syndrome (off label)

Antiseizures (inhibit Na+ channels)

Tx:  tonic clonic, absence, and complex partial seizures

AdRx:  BLACK BOX WARNING (SJS, TENS); ataxia, angoiedema, folic acid deficiency

Antiseizures (enhance GABA activity)

Tx:  adjunct therapy in adults and children 12+ with partial seizures

Monitor:  CBC, renal function, blood chem

Antiseizures (blocks NA+ channels, enhances GABA activity)

Tx: adjunct therapy for partial onset seizures in adutls and lannox-gastaut syndrome

AdRx:  hot flashes, kidney stones

Tx:  bipolar, wt. loss, nerve pain, migraines

Typical Neuroleptic DA (D2) receptor blocker high-potency

Tx: Tourettes

Typical Neuroleptic DA (D2) receptor blocker low-potency

Tx: intractable hiccups

high anti-ACH effects

No epileptics

Atypical Neuroleptic Serotonin (5HT) receptor blocker >> DA (D2) receptor blocker

Tx:  bipolar

S/e:  wt gain, sedation

Atypical Neuroleptic Serotonin (5HT) receptor blocker >> DA (D2) receptor blocker

1st line antipsychotic

Tx: tourettes, bipolar, autism

s/e:  galactorrhea (get prolactin levels)

Atypical Neuroleptic DA (D1 & D4) receptor blocker Serotonin (5HT) receptor blocker

s/e:  agranulocytosis, seizures, inc. salvation.

No epileptics

monitor WBCs (frequent blood tests)

Atypical Neuroleptic DA (D2)receptor blocker > Serotonin (5HT) blocker

Tx: bipolar

s/e: sedation

Atypical Neuroleptic Partial DA (D3) receptor agonist DA (D4) receptor antagonist (lower affinity)

tx: bipolar

MAOIs

s/e:  vitamin B6 deficiency

TCAs

most widely used TCA

most anti-ACH s/e

tx:  migraine, chronic pain syndromes

TCAs

bed wetting tx

greatest orthostatic hypotension, arrhythmias

TCAs

sedating

TCAs

least orthostatic hypotension

better for elderly

SSRIs

tx:  bulimia, kids 8+

s/e:  insomnia

SSRIs

s/e:  insomnia

food increases absorption

SSRIs

s/e:  hyponatremia, diarrhea, nausea, fatigue, insomnia

SSRIs

more sedating

SNRIs

tx:  depression, anxiety

s/e;  increases cholesterol

SNRIs

tx: depression, diabetic neuropathic pain

Atypical Antidepressants

no eating disorders, withdrawal from EtOH, seizure disorders

Atypical Antidepressants

sedative (antihistamine)

s/e:  wt gain, agranulocytosis, inc. cholesterol levels

dissolvable tablet

Atypical Antidepressants

sedative

s/e:  orthostatic hypotension, priapism, MI