Term
| What are the 8 adverse effects of Levodopa? |
|
Definition
| HTN Crisis (if taken w/ MAOI-A), Hypotension, Glaucoma, N/V/Anorexia, Psychosis, Brown saliva/urine, Dyskinesias. |
|
|
Term
| What drug increases the synthesis, release, and reuptake of Dopamine, is a cholinergic antagonist, and and NMDA-Glutamate antagonist? |
|
Definition
|
|
Term
| This dopa mimetic drug can cause orthostatic hypotension, urinary retention, and dry mouth. |
|
Definition
|
|
Term
| What drug is used with Levadopa to prevent the metabolism of Dopamine to 3OM-DOPA and penetrates the BBB. |
|
Definition
|
|
Term
| Drugs used to treat the "on/off sensation" that occurs during the use of other drugs used to treat Parkinson's. |
|
Definition
Tolcapone and Entacapone (DA metabolism inhib)
Apomorphine (DA agonist) |
|
|
Term
| What ergot alkaloid, used to treat Parkinson's, is contraindicated in pregnancy? |
|
Definition
|
|
Term
| What are the adverse effects of Bromocriptine? |
|
Definition
Pulmonary/Retroperitoneal Fibrosis
GERD
Peripheral Vasospasms
Arrthymias
Dyskinesias |
|
|
Term
| Adverse effects of the D2 agonists used for Parkinson's. |
|
Definition
(Pramipexole, Ropinerole, Rotigotine)
Nausea
Vertigo
Ortho hTN
insomnia
Somnolence (Modafinil for Sleep Attacks)
Inc in gambling, shopping, etc. |
|
|
Term
| What D2 agonists are contraindicated in Dementia and CNS Depressants? |
|
Definition
Pramipexole
Ropinerole
Rotigotine |
|
|
Term
| What are the contraindications for Apomorphine? |
|
Definition
Zofran
5HT3 antagonist
Severe Hypotension
Loss of consciousness |
|
|
Term
| Name the drugs contraindicated in Glaucoma, BPH, and Pyloric Stenosis. |
|
Definition
(Parkinson's Anti-Muscarinics)
Benztropine
Trihexyphenidyl
Biperiden |
|
|
Term
| What are the drugs used to treat Alzheimer's? |
|
Definition
(AChE inhibitors)
Donepezil Galantamine
Rivastigmine
Tacrine
(NMDA receptor inhibitor)
Memantine |
|
|
Term
| What Alzheimer's drug is considered "Neuroprotective"? |
|
Definition
Memantine
(NMDA receptor inhibitor) |
|
|
Term
| Name the Benzodiazepines. |
|
Definition
Oxazepam
Triazolam
Medazolam
Alprozolam
Temazopam
Lorazepam
Diazepam
Flurazepam
Clonazepam
Chlordiazeposdie
Clorazepate |
|
|
Term
| What do all Benzodiazapines lack? |
|
Definition
ANS side effects
Analgesic
Antipsychotic Actions |
|
|
Term
| What is the MOA of Benzodiazepines? |
|
Definition
Inc affinity of GABA to receptor
Inc Calcium influx --> Inc Hyperpolarization --> dec neuro firing |
|
|
Term
| What medication would you give for mild/acute anxiety? For example, to go on an airplane. |
|
Definition
|
|
Term
| What anti-anxiety drug would be used to induce amnesia? |
|
Definition
|
|
Term
| What drug would you most commonly see used in the ER for anxiety? |
|
Definition
|
|
Term
| Which drug is used for Grand-mal seizures? |
|
Definition
Diazepam
(benzodiazepine)
(also for severe anxiety and muscle relaxation) |
|
|
Term
| Drug used to treat chronic epillepsy. |
|
Definition
|
|
Term
| What would you use Alprazolam for? |
|
Definition
|
|
Term
| If a patient overdosed on benzodiazepines, what would you administer? |
|
Definition
|
|
Term
|
Definition
BuSpar
Atarax
Lunesta
Ambien
Sonata
Rozerem |
|
|
Term
| What is the method of action for Lunesta, Ambien, and Sonata? |
|
Definition
| BZ1 subset on GABA receptor |
|
|
Term
| Which BZ1 subset on GABA provides less of a "hangover" effect because it is NOT metabolized by CYP-34A? |
|
Definition
Sonata
(Ambien is metabolized by CYP-34A) |
|
|
Term
| What is the MOA for Rozerem? |
|
Definition
MT1 and MT2 receptor agonist
-maintenance of circadian sleep rhythm
-inhibits excitatory wakeful circuits |
|
|
Term
| What is the drug of choice for General Anxiety Disorder (GAD)? |
|
Definition
Buspar
-5HT 1A/2A Agonist
-D2 Agonist |
|
|
Term
What are the adverse effects of Lunesta?
|
|
Definition
Chest pain
Dry mouth
Migraine
Edema
Unpleasant taste
|
|
|
Term
| What two oral sedatives are used for rapid onset and elimination? |
|
Definition
|
|
Term
| What are the subgroups of drugs for anxiety? |
|
Definition
Benzodiazepines
Hypnotic/Sedatives
Non-Barbituates
CNS Stimulants (psychomotor/psychomimetic) |
|
|
Term
| What drug is used to block aldehyde synthesis? |
|
Definition
|
|
Term
| Name the drugs whose MOA is to inhibit phosphodiesterase, inc. cAMP & cGMP, and is an adenosine receptor antagonist? |
|
Definition
(Methylxanthines)
Caffeine
Theophylline
(Psychomotor CNS Stimulants for Anxiety) |
|
|
Term
| What is the MOA of Nicotine? |
|
Definition
N-Receptor Agonist
CNS and Ganglionic Stimulator |
|
|
Term
| What drug, in high doses, can cause respiratory paralysis and decrease coronary blood flow? |
|
Definition
|
|
Term
| What is the indication for Carbamazepine (Tegretol)? |
|
Definition
| Delerium Tremors during seizures |
|
|
Term
| What drug is an opiate antagonist? |
|
Definition
Naltrexone
(non-barb for anxiety) |
|
|
Term
| What drug would be used to relax bronchioles and smooth muscle? |
|
Definition
|
|
Term
| What is the MOA of Buproprion? |
|
Definition
Inhibit the re-uptake of DA/NE
(used to quit smoking) |
|
|
Term
| This drug's MOA is to increase DA release and is a N-Receptor partial agonist. |
|
Definition
|
|
Term
| This drug's MOA is to block the reuptake of NE, DA, and Serotonin. |
|
Definition
Cocaine
(at high dose: resp and vasomotor depression) |
|
|
Term
| What 3 drugs can be used to treat Narcolepsy? |
|
Definition
Modafinil
Adderal
Methylphenidate |
|
|
Term
| Hyperreflexia is an adverse effect of what drug? |
|
Definition
|
|
Term
| What drug is used to inhibit the reuptake of DA, 5-HT, NE, and is an NMDA receptor antagonist? |
|
Definition
|
|
Term
|
Definition
dissociative amnesia/numb extremities
staggered gait/slurred speech
muscle rigidity
Hostil/bizarre behavior |
|
|
Term
| Name the Benzodiazepine anti-epileptic drugs. |
|
Definition
Diazepam (status epilepticus)
Lorazepam (status epilepticus)
Clonazepam (myclonic/anti-convulsant)
Clorazepate |
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