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Pharm I - Test # 3 - Sedative Hypnotics
Fall Semester - 2010 - Pharm Test #3
33
Medical
Graduate
12/14/2010

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Term
What term describes the type of medicine that reduces anxiety and exerts a calming effect?
Definition
Sedative
Term
What term describes the type of medicine that produces drowsiness and encourages the onset and maintenance of sleep?
Definition
Hypnotic
Term
Why are benzodiazepines sometimes given to pts before a chemo treatment?
Definition
Because of their SE of Anterograde Amnesia which allows the pt to not remember the treatment
Term
Which med is described as a competitive benzodiazepine antagonist and as such reverses the sedative effects of it (especially useful for benzo OD)?
Definition
Flumazenil
Term
What are the main SE of Sedative Hypnotics as a drug group?
Definition
Dose-related CNS depression (drowsiness, impaired judgement, diminished motor skills)
Dose-related anterograde amnesia
Respiratory Depression (aspiration of gastric contents)
Term
Which med is used to help treat the severe ethanol with-drawl symptom of delirium tremens?
Definition
Lorazepam
Term
What are some non-pharmacologic methods of treating sleep disorders?
Definition
Proper diet and exercise
Avoiding Stimulants
Comfortable Sleeping Environment
Regular Sleep Schedule
Term
What is the appropriate time period for safe and effective extended use of most sedative hypnotics?
Definition
2 - 3 months
Term
Because benzodiazepines can cross the placental barrier, what SE can this have on the baby?
Definition
Can depress neonatal vital functions
Term
Do benzodiazepines penetrate the CNS? Why or Why not?
Definition
YES, because they are lipid soluable.
Term
Do Benzodiazapines enter the breast milk?
Definition
YES!
Term
Which benzodiazepines are short-acting? (2)
Definition
Midazolam & Triazolam
Term
Which Benzodiazepines are Intermediate-acting? (4)
Definition
Alprazolam
Estazolam
Lorazepam
Temazepam
Term
Which Benzodiazepines are long-acting? (4)
Definition
Clonazepam
Clorazepate
Diazepam
Flurazepam
Term
Which is more likely to decrease REM and slow wave sleep, Benzodiazepines or newer hypnotic sedatives?
Definition
Benzodiazepines
Term
Which is less likely to change sleep patterns, benzodiazepines or newer sedative hypnotics?
Definition
Newer sedative hypnotics
Term
Which more commonly causes daytime sedation, benzodiazepines or newer sedative hypnotics?
Definition
Benzodiazepines
Term
Which has a higher occurrence of tolerance development, benzodiazepines or newer sedative hypnotics?
Definition
Benzodiazepines
Term
Which has anterograde amnesia effects, benzodiazepines or newer sedative hypnotics?
Definition
Benzodiazepines
Term
Which has only a modest day-after psychomotor depression, benzodiazepines or newer sedative hypnotics?
Definition
Newer sedative hypnotics
Term
Which has a rapid onset of action, benzodiazepines or newer sedative hypnotics?
Definition
Newer sedative hypnotics
Term
Which has few amnestic effects, benzodiazepines or newer sedative hypnotics?
Definition
Newer sedative hypnotics
Term
Which newer sedative hypnotic can cause SE including "sleep driving and eating"?
Definition
Zolpidem (Ambien)
Term
Which sedative hypnotic is the MC prescribed hypnotic drug in the US?
Definition
Zolpidem (Ambien)
Term
What does the biphasic formulation for Zolpidem do?
Definition
Helps the drug last throughout the night
Term
What are the indications for Zolpidem? (3)
Definition
1 - Reduce sleep latency (fall asleep faster)
2 - Reduce sleep awakenings
3 - Increase total sleep time
Term
What are the indications for Eszopiclone? (3)
Definition
1 - Reduce sleep latency (fall asleep faster)
2 - Reduce sleep awakenings
3 - Increase total sleep time
Term
Which sedative hypnotic has a rapid onset formula that is very effective for the treatment of sleep awakenings? What is another indication for this drug?
Definition
Zaleplon (Sonata) ; decreased time to sleep onset
Term
Which sedative hypnotic drug is used to treat anxiety and depression due to its anxiolytic effects?
Definition
Buspirone
Term
What is the indication for the use of Ramelteon? (1)
Definition
1 - Reduces sleep latency (Fall asleep faster)
Term
Which sedative hypnotic is labeled for LONG term use, meaning every night for 6 months?
Definition
Eszopiclone (Lunesta)
Term
Which sedative hypnotic takes 1 week for full effects to kick in?
Definition
Buspirone
Term
What are the SE of Flumazenil? (4)
Definition
Agitation
Confusion
Dizziness
Withdrawl symptoms
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