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Pharm - Hypertension
Exam 3
59
Pharmacology
Graduate
03/23/2010

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Cards

Term
hydrochlorothiazide
Definition
thiazide

DOC for uncomplicated HTN
Term
indapamide
Definition
thiazide

increases effectiveness of loop diuretic
Term
metolazone
Definition
thiazide

increases effectiveness of loop diuretic
Term
chlorthalidone
Definition
thiazide
Term
furosemide
Definition
Lasix

loop diuretic
Term
torsemide
Definition
loop diuretic
Term
bumetanide
Definition
loop diuretic
Term
spironolactone
Definition
K sparing diuretic
Term
triamterene
Definition
K sparing diuretic
Term
eplerenone
Definition
K sparing diuretic
Term
acetazolamide
Definition
carbonic anhydrase inhibitor
Term
atenolol
Definition
beta blocker
Term
metoprolol tartrate
Definition
beta blocker
Term
metoprolol succinate
Definition
beta blocker
Term
nebivolol
Definition
beta blocker

racemic mixture
d - beta blocker
l - vaso dilator
Term
propranolol
Definition
beta blocker

nonselective
used for migraines
Term
captopril
Definition
ACE Inhibitor

used short term after MI (tid)
Term
lisinopril*
Definition
ACE Inhibitor

starting 10 mg PO QAM
Term
enalapril*
Definition
ACE Inhibitor

starting 5 mg PO QAM
Term
benazapril
Definition
ACE Inhibitor
Term
quinapril
Definition
ACE Inhibitor
Term
fusinopril
Definition
ACE Inhibitor
Term
moexipril
Definition
ACE Inhibitor
Term
perindopril
Definition
ACE Inhibitor
Term
trandolapril
Definition
ACE Inhibitor
Term
ramipril
Definition
ACE Inhibitor

more lipophilic
Term
losartan*
Definition
ARB

starting dose 25 mg PO QAM
25, 50, 100 mg tabs
Term
valsartan*
Definition
ARB

starting dose 80 mg PO QAM
40, 80, 160, and 320 mg tabs
Term
irbesartan
Definition
ARB
Term
candesartan
Definition
ARB
Term
olmesartan
Definition
ARB
Term
eprosartan
Definition
ARB
Term
telmisartan
Definition
ARB
Term
amlodipine*
Definition
Calcium channel blocker
dihydropyridine

treat angina

starting 5 mg
2.5, 5, and 10 mg tabs
Term
felodipine*
Definition
Calcium channel blocker
dihydropyridine

starting 5 mg
2.5, 5, and 10 mg tabs
Term
nifedipine*
Definition
Calcium channel blocker
dihydropyridine

starting 30 mg
30, 60, and 90 mg tabs
Term
diltiazem*
Definition
Calcium channel blocker
benzothiazipine

starting 180 mg
120, 180, 240, 360, 420 mg tabs
Term
verapamil
Definition
calcium channel blocker
diphenylalkylamine
Term
doxazosin*
Definition
alpha-1 blocker

1 mg PO QPM, increase every 3-5 days to target dose
Term
terazosin
Definition
alpha-1 blocker
Term
tamsulosin
Definition
alpha-1 blocker

No BP effects
Term
prazosin
Definition
alpha-1 blocker

No BP effects
Term
clonidine*
Definition
Central alpha-2 Agonist

0.1-0.2 m PO hypertensive crisis
Term
methyldopa
Definition
Central alpha-2 Agonist

DOC for HTN in pregnancy
Term
reserpine
Definition
adrenergic inhibitor
Term
hydralazine
Definition
vasodilator
Term
minoxidil
Definition
vasodilator
Term
aliskiren
Definition
renin inhibitor
Term
Give the best drug for HTN:
Post MI
Definition
Beta blocker and ACE-I
Term
Give the best drug for HTN with:
High coronary disease risk
Definition
Beta blocker
Term
Give the best drug for HTN with:
Diabetes mellitus
Definition
ACE-I or ARB
Term
Give the best drug for HTN with:
recurrent stroke prevention
Definition
ARB
Term
Give the best drug for HTN with:
metabolic syndrome
Definition
ACE-I
Term
Fertile females with HTN
Definition
No ACE-I, ARBs, or renin inhibitors
Term
Post-menopausal women with HTN
Definition
thiazide diuretic

inc. Ca2+ retention
Term
African Americans with HTN
Definition
combo therapy
Term
High BP risks
Definition
MI, heart failure, stroke, and kidney disease
Term
Age 40-70
over 115/75 - 185/115

risk of CVD does what with each increment of 20 DP or 10 SP?
Definition
doubles with each increment
Term
Anti-HTN therapy
% stroke reduction
% MI reduction
% heart failure reduction
Definition
35-40% stroke reduction

20-25% MI reduction

> 50% HF reduction
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