Shared Flashcard Set

Details

Pharm Final
N/A
92
Pharmacology
Graduate
11/30/2010

Additional Pharmacology Flashcards

 


 

Cards

Term
Diazepam
Definition
Benzodiazepine, Increases the action of GABA, Treats Anxiety, Depressant, Must taper to discontinue; also used to treat status epilepticus
Term
Alprazolam
Definition
Benzodiazepine, Increases Action of GABA, Treat Anxiety, Depressant. Must taper to discontinue
Term
Lorazepam
Definition
Benzodiazepine, Increase the action of GABA, Treat Insomnia, Depressant, must taper to discontinue, treat bipolar disorder
Term
Zolpidem
Definition
Nonbenxodiazepine, Specifically bind to GABA type A receptor, treat insomnia, 1 hour half-life, good for falling asleep
Term
Eszopiclone
Definition
Nonbenzodiazepine, specifically bind to GABA type A receptor, Treat Insomnia, Half-life of 1.5-2.4 hours
Term
Ramelteon
Definition
Nonbenzodiazepine, High-affinity binding to melatonin receptor, treat insomnia, Half-life of 5-7 hours, sleep maintenance
Term
Kava Kava
Definition
Nonbenzodiazepine, Herbal product, tx insomnia
Term
Valerian
Definition
Herbal product, placebo, sleep better
Term
Carbamazepine
Definition
Treat Epilepsy, Inhibit Glut R, treats partial and tonic clonic seizures, treat bipolar disorder
Term
Phenytoin
Definition
Treats Epilepsy, Inactivates Na+ channels, treats status epilepticus, Class 1, may cause ataxia and nystagmus
Term
Ethosucimide
Definition
Treat Epilepsy, decrease action of calcium, trean absence seizures, may cause stomach aches, vomiting, and hiccups
Term
Valproate
Definition
Treat Epilepsy, Increase GABA, treat tonic-clinic and absense seizures, may get tremor or weight gain, treat bipolar disorder
Term
Lamotrigine
Definition
Treat Epilepsy, Inhibit GluR, Treat partial seizures, may get rash
Term
Phenobarbital
Definition
Inhibit GluR, treat partial seizures, secondary drug, older
Term
Topiramate
Definition
Inhibit GluR, treat partial seizures, migraine, manic-depression and neuropathic pain, may get bilateral acute angle
Term
Entacapone
Definition
Treat Parkinson's Disease, COMT inhibitor, increase half-life of L-Dopa
Term
Bromocriptine
Definition
Dopamine agonist, Treat Parkinson's, acromegaly
Term
Ropinirole
Definition
Dopamine agonist, treat parkinson's
Term
Amantadine
Definition
Antiviral agent, treat Parkinson's disease, mild treatment activity
Term
Trihexyphenidyl
Definition
Anticholinergic, treat Parkinson's disease, for younger patients who have a lot of ACh to spare
Term
Donepezil
Definition
Cholinesterase Inhibitor, Tx Alzheimer's
Term
Rivastigmine
Definition
Cholinesterase Inhibitor, Treat Alzheimer's
Term
Galantamine
Definition
Cholinesterase Inhibitor, Tx Alzheimer's
Term
Memantine
Definition
Glutamate receptor antagonist, treat Alzheimer's, neuroprotective
Term
Chlorpromazine
Definition
Block postsynaptic D2 receptors, centrally and peripherally, tx positive symptoms of schizophrenia, can cause opaque deposits in cornea and lens
Term
Amitriptyline
Definition
Increase NE and 5-HT in CNS by blocking reuptake, Treat Depression
Term
Fluoxetine
Definition
Block reuptake of 5-HT, Treat depression,
Term
Alendronate
Definition
Selectively Inhibit bone demineralization, increase bone density, first choice in osteroporosis
Term
Calcitonin
Definition
Reduce calcium in blood, protect againt calcium loss in skeleton
Term
Raloxifene
Definition
Selective estrogen receptor modulator, replaces estrogen which decreases bone demineralization,
Term
Doclofenac
Definition
NSAID, analgesia, Rheumatoid arthritis
Term
Hyrocodone
Definition
Potent opioid, analgesia, rheumatoid arthritis
Term
Hydroxychloroquine
Definition
Anti-malaria drug, reduce/prevent joint damage, can cause deposits in retina and cornea
Term
Sulfasalazine
Definition
IBD drug, preserve joint integrity and function,
Term
Methotrexate
Definition
anti-metabolite drug, preserve joint integrity and function
Term
Tubocurarine
Definition
Depolarizing agent, occupy and activate, relax muscle
Term
Tubocurarine
Definition
Depolarizing agent, occupy and activate, relax muscle
Term
Succinylcholine
Definition
Nondepolarizing, antagonize Ach on nicotinic receptor, relax muscle, can cause malignant hyperthermia
Term
Cyclobenzaprine
Definition
GABA agonist, act through CNS, relax muscle
Term
Dantrolene
Definition
Direct-Acting skeletal muscle relaxant, relax muscle
Term
Penicillin, Nafcillin, Dicloxacillin, Amoxicillin
Definition
Interfere w/ synthesis of peptidoglycans, bacteriostatic, treat staph, strep, UTIs, broad
Term
Cephalexin
Definition
Affect bacterial cell membrane, bactericidal, 1st generation
Term
Vancomycin
Definition
inhibit cell wall synthesis, only active against gram +, bactericidal, Macrolie, only used for MRSA
Term
Bacitracin
Definition
Inhibit cell wall synthesis, only active against Gram+, bactericidal, treat blepharitis, red neck syndrome
Term
Azithromycin
Definition
Bactericidal against G+ and _, chlamydia, conjunctivitis, used on children
Term
Tetracycline, Doxycline
Definition
inhibits protein synthesis in G+ and G-, bacteriostatic, treat most chlamydia, bad for children's teeth
Term
Chloramphenicol
Definition
Bind to 50S, inhibit protein synthesis, bacteriostatic, treat serious rickettsia, rarely given because of risk of aplastic anemia resulting in Gray Baby Syndrome
Term
Isoniazid
Definition
Inhibit synthesis of mycolic acids, treat TB, usually need multiple drugs to tx
Term
Rifampin
Definition
Inhibit RNA synthesis, treat TB, Orange secreations
Term
Ethambutol
Definition
Inhibits transferases essential for cell wall, tx TB,
Term
Amphotericin B
Definition
Disrupt fungal membrane, ergosterol, broad specturm, limited by toxicity
Term
Flucytosine
Definition
anti-metabolite, prodrug, inhibit DNA and RNA synthesis, treat fungal infection, used in combination therapy
Term
Ketoconazole and Clotrimazole
Definition
Inhibit fungal cytochrome P450 enzyme, treat fungal infection, used in antifungal shampoo
Term
Caspofungin
Definition
disrupt cell wall, treat fungal infection
Term
Griseofulvin
Definition
Binds to keratin in newly forming skin, treat skin and hair fungal infections
Term
Terbinafine
Definition
Disrupt fungal membrane, inhibit membrane synthesis, tret nail infections
Term
Valacyclovir
Definition
Acyclovir prodrug, tx genital herpes and herpes zoster
Term
Famiciclovir
Definition
prodrug to peniiclovir, treat genital herpes and herpes zoster
Term
Ganciclovir and Foscarnet
Definition
IV administration, treats retinitis, epithelial keratitis, antiviral
Term
Chloroquine
Definition
concentrate in parasitic food vacuoles, treat malaria
Term
MRSA drugs
Definition
Doxycycline, Clindamycin, Vancomycin
Term
TobraDex
Definition
Tobramyxin + Dexamethasone, treat acute red eye, epidemic keratoconjunctivitis
Term
Zylet
Definition
Tobramycin + Loteprednol, treat acute red eye, EKC
Term
Maxitrol
Definition
Neomycin+Polymyxin B + Dexamethasone, tx acute red eye and EKC, not used frequently because of neomycin rxns
Term
Physostigmine and Echothiophate
Definition
cholinesterase inhibitor, miosis, glaucoma drug==increase outflow
Term
Pilocarpine
Definition
Muscarinic Antagonist, miosis, Glaucoma--increase outflow
Term
Atropine
Definition
Muscarinic Antagonist, dilation, treat Cholinesterase poisoning
Term
Propanolol and Timolol
Definition
Beta-Blocker, sympatholytic, Glaucoma drug, decreases production, slow hear rate and dilate vessels
Term
Betaxolol
Definition
B1-selective blocker, sympatholytic, can be used in asthmatic patients, Glaucoma drug, decreases production, slow heart rate and dilate vessels
Term
Tropicamide
Definition
Cholinergic antagonist, Cycloplegic, dilate pupil and paralyze accommodation
Term
Brimonidine
Definition
Alpha-2 Adrenergic Agonists, decrease production, increase outflow
Term
Acetazolamide and Brinzolamide
Definition
Carbonid Anhydrase Inhibitors, Glaucoma drugs, decrease production
Term
Isosorbe and Mannitol
Definition
Creat an osmotic gradient between ocular fluid and cornea, lower IOP
Term
azithromycin
Definition
antiinflammatory antibiotic, tx posterior blepharitis
Term
Loteprednol
Definition
supress inflammation, ester base, works like corticosteroid
Term
Nepafenac
Definition
NSAID, tx pain and inflammation, prodrug
Term
Olapatadine
Definition
H1 receptor blocker, antihistimine and mast cell stabilizer,
Term
Prednisolone
Definition
Supress inflammation, topical steroid, episcleritis, iritis, uveitis, (Pred Forte)
Term
Dexamethasone
Definition
steroid, decrease inflammation, lots of side-effects, Inc IOP and cataracts
Term
Fluorometholone acetate
Definition
FML, steroid, antiinflammatory
Term
cyclosporine
Definition
inhibit transcription of interleukin, immunosuppressant, tx allergies
Term
Proparacaine
Definition
Ester group, PABA, prevent generation and conduction of nerve impulses, reduce sodium permeabilit, inc excitation threshold, slow nerve impulse propagation, local anesthsia, loosens epithelium of cornea and reduces reflexive tears
Term
Bupivacaine, Lidocaine and Mepivacaine
Definition
Amide group, benzoic acid, local anesthesia, used in minor surgical procedures
Term
Rose bengal and lissamine green
Definition
Stains dead and degenerated cells, allows assessment of dry eye, rose bengal can cause irritation
Term
sodium fluorescein
Definition
produces intense green in alkaline solution, allows for assessment of cornea, IV admin
Term
Indocyanide green
Definition
bind to blood protein, visualize retinal and choroidal vessels, better than sodium fluorescein
Term
Verteporfin
Definition
LDL from complex w/ drug, quickly absorbed into new vessels, red light kills abnormal vessels
Term
Lidocaine and Phenytoin
Definition
Class 1, bind to sodium channel, slow conduction velocity
Term
Amiodarone
Definition
Class 3, block potassium and sodium channels, stabilize dysrhythmia, can leave deposites on cornea nd optic neuritis
Term
Amiloride
Definition
Block Na channel @ distal convoluted tubule and collective duct, produce mild diuresis, potassium-sparing diuretic,
Term
Ammonium chloride
Definition
acid-forming salt, dec water and remove extra ECF to dec edema
Term
Acetazolamide
Definition
CAI, stop conversion of carbonic acid and bicarbonate into CO2, decrease permeability at procimal tubule
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