Term
| Symptoms of Parkinson's Disease |
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Definition
1. Rigidity
2. bradykinesia
3. resting tremor
4. postural instability |
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Term
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Definition
-Lose dopamine containing neurons w. cell bodies in substantia nigra to striatum
-Dark neurons contain high amt melanin
-70-80% lost before see symptoms |
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Term
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Definition
-Aging = gradual loss of nigrostriatal dopamine neurons
-Small # genetically linked (eg. mutated a-synuclein)
-Some toxins such as MPTP selectively kills these neurons |
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Term
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Definition
Dopamine precursor
converted by DD (Dopa Decarboxylase) enzyme
-Given w. carbidopa to allow more to enter CNS |
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Term
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Definition
Tx lasts 5-10 yrs
ON/OFF phenomenon - may be due to diet and competition w/ other amino acids |
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Term
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Definition
-Extrapyramidal abnormalities- dyskinesia, nausea,
-psych symptoms at high doses
-postural hypotension
-Some think may inc. loss of dopaminergic neurons |
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Term
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Definition
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Term
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Definition
COMT Inhibitor
-inhibits conversion of L-Dopa to 3-0 methyldopa in periphery = inc. 1/2 life in PERIPHERY |
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Term
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Definition
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Term
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Definition
-Diarrhea
-Inc. sensitivity to L-Dopa
-Hepatotoxicity |
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Term
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Definition
Direct acting DA agonist (D1/D2)
-Acts on receptors in striatum pathway |
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Term
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Definition
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Term
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Definition
D2 agonist
D3 agonist
-act directly on DA receptors |
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Term
| Tx Use of Ropinirole & Pramipexole |
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Definition
Often combined w. L-DOPA
lower doses of each required
-less side effects than bromocriptine |
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Term
| SEs of Ropinirole & Pramipexole |
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Definition
Nausea
Dyskinesia
Confusion
Hallucinations |
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Term
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Definition
Muscarinic antagonist
DA inhibits Ach (which -> GABA release)
More DA in Striatum |
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Term
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Definition
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Term
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Definition
-Anti-parasympathetic:
xerostomia, dec. sweating, inc. HR, urinary retention, dec. short term memory |
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Term
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Definition
Antiviral
Inc. DA release
Unknown mechanism |
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Term
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Definition
| Half as efficacious as L-DOPA |
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Term
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Definition
Mild:
restlessness
depression
hypotension |
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Term
| Contraindication of Amantadine |
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Definition
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Term
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Definition
MAO-B blocker
MAO-B metabolizes Dopamine |
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Term
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Definition
Low effectiveness
Claim neuroprotection |
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Term
| Contraindications of Selegiline |
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Definition
| NOT w. meperidine or TCA's bc = Hyperthermic of HTN |
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