Term
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Definition
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Term
|
Definition
-Block NE and Serotonin UPTAKE
-Block muscarinic, mistaminergic, and alpha 1 adrenergic receptor Side Effects |
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Term
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Definition
-Elevate mood
- Reverse depression
-Neuropathic pain
-Enuresis
-OCD
- Cataplexy (Narcolepsy) |
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Term
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Definition
-Atropine like:
xerostomia, blurred vision, constipation
-Anti-histamine:
mild sedation, hypotension, fatigue
***Cardio- toxicity*** slows conduction, torsade de pointe |
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Term
| Contraindications of Imipramine |
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Definition
-Heart problems
-Bipolar disorder (can --> Mania) |
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Term
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Definition
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Term
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Definition
| -Inhibits Serotonin and NE reuptake |
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Term
| How is Venlafaxine different from tricyclic |
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Definition
Does NOT also block muscarinic, histaminergic, and a-1 adrenergic receptor SEs
Tricyclics do |
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Term
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Definition
-Blocks alpha 2 receptors = enhances neurotransmission through 5HT1
-Blocks 5HT2 and 5HT3 |
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Term
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Definition
Depressions
Anti-anxiety possibly |
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Term
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Definition
-SSRI like:
Headache, Inhibits Cytochrome P450
-Does not cause nausea, Vomiting or cardio-toxicity |
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Term
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Definition
| -Blocks uptake Monoamines (NE, 5HT, DA) |
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Term
|
Definition
smoking cessation
depression |
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Term
| Buproprion difference in SEs |
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Definition
|
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Term
| Examples of Selective Serotonin reuptake Inhibitors |
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Definition
Fluoxetine- Prozac
Paroxetine- Paxil
Sertraline- Zoloft |
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Term
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Definition
| Specific blocks reuptake of Serotonin (5HT) |
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Term
|
Definition
Depression
Atypical depression |
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Term
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Definition
-Nausea/Vomiting
-Headache
-Sexual dysfunction
-Inhibits Cytochrome P450
-No cardiac effects like TCAs |
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Term
|
Definition
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Term
| Which SSRI has the longest half life? |
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Definition
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Term
|
Definition
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Term
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Definition
Inhibits MAO
Blocks deamination of monoamines (NE,dopamine, serotonin, and tyramine) |
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Term
|
Definition
-Reverse Psychomotor retardation in depressed pts
-Atypical Depression
- Can Inc. Psychomotor activity to hypomanic or mania |
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Term
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Definition
-Hepatotoxicity, tremors, insomnia, hyperhidrosis
-Convulsions
-Peripheral Neuropathy
-Interferes w. metabolic degradation of anesthetics, antihistamines, alcohol, analgesics
-Potentiates CV effects of sympathomimetic amines = HYPERTENSIVE CRISIS |
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Term
| Contraindications of MAO-I |
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Definition
-Not w. SSRI = Central Serotonin Syndrome = hyperpyrexia, confusion, and death
-Tyramine = HTN crisis = food w. tyramine (beer, wine, cheese, coffee) |
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Term
|
Definition
Lithium
Sodium Valproate
Divalproex
Carbamazepine |
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Term
|
Definition
-Looks like Na+
-Dec. cAMP and Ca2+ dignaling
-Inc. Permeability of Na channels = accumulation in active neurons |
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Term
|
Definition
Prophylaxis- Bipolar disorder
-Acute Tx manic phase
-Adjunct Tx in refractory depression |
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Term
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Definition
-Anorexia
-Ataxia
Blurred vision
slurred speech
Muscular weakness
Polyuria
Kidney toxicity
Convulsions
Coma
Death |
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Term
| Contraindications of Lithium |
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Definition
-Low therapeutic index
-Low Na diet |
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Term
| Sodium Valproate Divalproex Uses |
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Definition
| Acute mania in Bipolar disorder |
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Term
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Definition
| Mood stabilizer in Bipolar |
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