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Pharm Exam 2: Cardiac Contractility Modulators
N/A
4
Pharmacology
Professional
10/06/2012

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Cards

Term
Epi, NE, Dopamine, Dobutamine
Definition
  • Epi, NE not too useful
  • Dopamine and Dobutamine stimulate B1 receptors to increase CO with less vasoconstriction (less A1 activation)
  • All have limited use; can't use with a patient on Beta blockers
Term
Milrinone
Definition
  • PDE3 inhibitor
  • increased cAMP levels to increase contraction
  • Mimics dopamine and dobutamine
  • Short term use only, IV
  • Can work with B-blockers: works downstream from them
Term
Digoxin
Definition
  • Cardiac glycoside
  • Decrease Ca efflux (Na/CA exchanger inhibited via Na/K pump inhibition)
  • Indirect by increasing intracellular Na: decreased Ca efflux through exchanger. 
  • Decreased automaticity, slow conduction, very arrhythmogenic (AV block)
  • Also increased PANS activity, stimulated CNS vomiting, dizziness, drowsiness, diarrhea, blurred vision
  • Narrow therapeutic index, lots of drug interactions (increased binding with low K+)
Term
Pimobendan
Definition
  • Enhances contractile process directly; Ca sensitizer
  • Increases calcium binding to troponin C
  • Not assoc w/ arrhythmias
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