Term
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Definition
strong inducer
autoinduction
inducer of CYP enzyme
metabolize drugs faster
increased clearance w/increased dose
BBW: rash, blood dyscrasias |
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Term
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Definition
| reduces currents on the T-type Ca2+ channels |
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Term
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Definition
BBW: aplastic anemia, hepatic failure
Antagonizes the NMDA receptor and it may also potentiate GABA-A receptor responses |
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Term
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Definition
Does not act directly on GABA recpetors, may modify the release of GABA
Binds to a subunit of voltage-gated Ca2+ channels, decreasing Ca2+ entry, decreases the release of glutamate |
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Term
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Definition
| Enhances slow inactivation Na+ channels, binds to CRMP-2 |
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Term
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Definition
BBW: rash
Prolongs inactivation Na+ channels, Ca++ channels, inhibits glutamate release |
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Term
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Definition
| Modifies the synaptic release of glutamate and GABA through an action on SV2A |
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Term
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Definition
strong inducer
prolongs inactivation of Na+ channels, actions on K+ channels |
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Term
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Definition
strong inducer
GABA receptors: prolong the time of each channel opening |
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Term
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Definition
strong inducer
saturation of metabolism, point where you are not able to metabolize any more drug (over this leads to toxicity)
prolongs inactivation of Na+ channels |
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Term
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Definition
Does not act directly on GABA recpetors, may modify the release of GABA
Binds to a subunit of voltage-gated Ca2+ channels, decreasing Ca2+ entry, decreases the release of glutamate |
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Term
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Definition
| GABA receptors: prolong the time of each channel opening |
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Term
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Definition
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Term
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Definition
| Inhibitor of GABA reuptake |
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Term
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Definition
| Acts on AMPA receptors, blocking the glutamate binding site. Also blocks kainate receptors and Na+ channels, and enhances GABA currents |
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Term
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Definition
strong inbitor
BBW: hepatic fighter, pancreatitis, teratogenic |
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Term
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Definition
BBW: vision loss
irreversible inhibitor of GABA aminotransferase (GABA-T), the enzyme responsible for the degredation of GABA. It may also inhibit the vesicular GABA transporter |
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Term
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Definition
| Prolongs inactivation Na+ channels, T-type Ca++ channels |
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