Term
| Estrogens and Progestins are indicated in what (4) disorders? |
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Definition
1. Primary hypogonadism (surgical oopherctomy, genetic)
2. HRT (Postmeno sx)
3. Contraception (dysmenorrhea, acne)
4. Osteoporosis |
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Term
| Minor adverse effects of estrogen and progestins include: |
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Definition
| Breast tenderness, H/A, edema, N/V, anorexia, changes in libido |
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Term
| Major adverse effects of estrogen and progestins include: |
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Definition
| HTN, thromboembolism, gallbladder dz, dementia, stroke, hypercalcemia, endometrial cancinoma |
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Term
| What is Diethystilbesterol (DES)? What is it used for? What was it used for in the past? |
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Definition
| DES is a nonsteroidal estrogen. It used ONLY in the tx of inoperable breast or prostate Ca. It was used in the past to prevent prego women from having a miscarriage- offspring of these women had higher incidence of vaginal/cervical Ca. |
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Term
| Examples of oral progesterone include: |
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Definition
1. Megestrol (Megace)
2. Progesterone (Prometrium)
3. Medoxyprogesterone acetate (Provera) |
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Term
| Examples of IM progesterone include: |
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Definition
1. Hydroxyprogesterone caproate (generic only)
2. Medroxyprogesterone acetate (Depo-Provera) |
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Term
| When is progesterone indicated ? |
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Definition
1. Suppress ovarian fxn (dysmenorrhea, endometriosis, uterine bleeding)
2. HRT (combined with estrogen-prevents endometrial Ca, estrogen induced irregular bleeding, uterine hyperplasia) |
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