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PHARM-EXAM1
ADRENERGIC AGENTS AND BLOCKING AGENTS
43
Pharmacology
Graduate
12/04/2012

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Cards

Term
Alpha 1 receptors
Definition
located on postsynaptic effector cells
Any drug that looks like NE and cause VC and increase in BP
Term
Alpha 1 receptors
Definition
Agonist NE
Antagonist Phentolamine
Term
Phentolamine
Definition
Alpha 1 antagonist
Term
Alpha 2 receptors
Definition
located on presynaptic nerve terminals
and control the release of neurotransmitters
Term
Alpha 2 receptors
Definition
Agonist: NE
Antagonist: none
Term
Alpha 2 receptors
Definition
have feedback mechanism and therefore decrese release of NE or dec BP
Term
Alpha agonist responses
Definition
are vasocontriction and CNS stimulation
Primarily located on smooth muscle, vasculature or blood vessels
Term
Beta1 receptors
Definition
located primarily in the heart
stimulation cause increase HR
Term
Beta2 receptors
Definition
located in smooth muscle of the bronchioles, arterioles, and visceral organs
Stimulation relax smooth muscle and cause bronchiodilation or vasodilaiton
Term
Beta agonists
Definition
resultsi in: bronchial, GI, and uterine smooth muscle relaxation
GLycogenolysis
Cardiac stimulation
Term
Dopaminergic receptors
Definition
stimulated by Dopamine to inc HR
and causes dilation of the following blood vessels resulting in increase blood flow:
Renal
Mesenteric
Coronary
Cerebrel
Term
alpha 1 receptor locations
Definition
Sphincters: constriction (no food allowing
Blood vessels: constriction inc HR
Bladder sphincter: constri no digestion
Penis: ejaculation make cums
Ureus: constriction no pee just cum
Term
Beta 2 receptor location
Definition
Uterus: relaxation before labor to open the uterus
GI muscle: decrease motility no digestion
Blood vessels: dilation
Lung: inc dilation and relaxaiton to breath better
Term
Beta 1 receptor location
Definition
Heart: increase HR and contractility
Term
Phenyl-ethyl-amine
Definition
is the parent coumpound with sympahtomimetic drugs

Substitutions are at terminal amino group, by OH at 3,4 of benzene, alpha or beta carbons yield Catecholamines
Term
Phenylethylamine
Definition
is modified to change affinity and selectivity of drugs for alpha and beta receptors
Term
Epinephrine
Definition
50% alpha
50% beta
Term
Norepinephrine
Definition
95% alpha
5% beta
Term
Isoproterenol
Definition
95% beta
5% alpha
Term
Synthesis of NE
Definition
Tyrosine--(tyrosine hydrosylase)---
DOPA---(dopa decarboxylase)---
Dopamine---(dopamine-beta-hydroxylase)----
NE---(Phenylethanolamine-methyl transferase--)
EPinephrine
Term
NE and Epinephrine
Definition
through MAO and COMT to make MHPG and VMA to secrete through urine
Term
Adrenergic agonists
Definition
Direct acting sympathomimetic:
binds directly to the receptor and causes a physiologic response

Indirect-acting sympathomimetic:
causes the release ot catecholamine from the storage sites in the nerve endings
Term
Adrenergic agonists
Definition
"Tyramine-like" effect: drug interaction of MAOI with tyramine foods (beer, fava beans, cheese, yeast red wine...) will result in hypertensive crisis
Term
TYRAMINE
Definition
Normal by-product of tyrosine metabolism
Fermented foods cheese
Inactive oral because of high first pass effect, low bioavilability
IV
Term
TYRAMINE
Definition
IV has indirect sympathomimetic action result of release of stored catecholamine
Drug interaction with MOAI, effect of tyramine is intensified, hypertensive crisis
Patient on MAOI must avoid tyramine containing foods
Term
TYRAMINE containing foods
Definition
Broad beans, fava beans
Cheese, natural or aged, cheddar gruyere
Chicker liver
Chocolate
Sausage
Smoked herring
Snails
Wine
Yeast
Term
Benzphetamine
Definition
Anorexiants: adjuncts to diet in the short-term management of obesity
Term
Phentermine
Definition
Anorexiants: adjuncts to diet in the short-term management of obesity
Term
Dextroamphetamine
Definition
Anorexiants: adjuncts to diet in the short-term management of obesity
Term
Dexedrine
Definition
Anorexiants: adjuncts to diet in the short-term management of obesity
Term
Albuterol
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Isoetharine
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
terbutaline
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Ephedrine
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Epinephrine
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Isoetharine
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Levalbuterol
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
salmeterol
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Metaproterenol
Definition
Bronchodilators: treatment of asthma and bronchitis by stimulate Beta 2 adrenergic receptors of bronchial smooth muscle causing relaxation
Term
Isoproterenol
Definition
Non-selective B1,B2 agonist
Most potent
Indication: bronchiodilator
Inhaler rapid onset
SE: cardiac arrhythmia
Term
Isoethraine
Definition
Non-selective B1, B2
Inhaler
For Bronchiodilator
Term
Terbutaline
Definition
Prototype oral
B2 selective
PO (peorum mean by mouth),
subcutaneous, inhaler, and Iv
PO long duration
Will cause cardiac arrhythmia only at higher doses
SE:
skeletal muscle tremor
restlessness
Term
Ritoridine
Definition
B2 agonist
Relaxes uterine smooth muscle
Indication: premature labor
may also used terbutaline
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