Term
| What drugs are in this Drug Class: Folic acid synthesis inhibition? |
|
Definition
| Sulfonamides & Trimethoprim |
|
|
Term
| What drugs are in this Drug Class: Inhibit DNA gyrase, DNA synthesis? |
|
Definition
|
|
Term
| What drugs are in this Drug Class: DNA damage? |
|
Definition
|
|
Term
| What drugs are in this Drug Class: Inhibit mRNA synthesis? |
|
Definition
|
|
Term
| Sulfisoxazole is what type of drug? |
|
Definition
|
|
Term
| Sulfamethoxazole is what type of drug? |
|
Definition
|
|
Term
| Sulfonamides are Analogs of _____ |
|
Definition
| PABA (para-amino benzoic acid) |
|
|
Term
| Sulfonamides Compete with ____ in synthesis of folic acid a required precursor of ___ & ____ DNA bases |
|
Definition
|
|
Term
| Trimethoprim is what type of drug? |
|
Definition
| An antibiotic that inhibits folic acid synthesis |
|
|
Term
| Trimethoprim is a Competitive inhibitor of ______ and Inhibits ____ conversion to purines/pyrimidines |
|
Definition
dihydrofolate reductase
folic acid |
|
|
Term
Sulfamethoxazole + Trimethoprim
(Co-trimoxazole, SMZ/TMP or TMP-SMX, Bactrim, Septra)
Combination produces a _____ inhibition because two sequential steps in folic acid pathway are blocked |
|
Definition
synergistic
* know bactrim |
|
|
Term
| Sulfonamides & Trimethoprim has ____ Toxicity |
|
Definition
|
|
Term
| Bacteria have no ____ transport for folate and must synthesize it. ____ inhibit this synthesis. |
|
Definition
|
|
Term
| Trimethoprim is 20,000 x more potent at inhibiting ______ dihydrofolate reductase than ____ enzyme. |
|
Definition
|
|
Term
| Humans cannot synthesize folate – must obtain from diet via Active uptake. Human dietary folate deficiency causes ____. |
|
Definition
|
|
Term
| ____ is another folate antagonist (inhibits dihydrofolate reductase) used clinically at high does to treat cancer & at low doses to treat RA (rheumatoid arthritis) and severe psoriasis |
|
Definition
|
|
Term
Sulfonamides & Trimethoprim:
Bacterio____
Very ____ spectrum
Distribute to ___ body fluids including ___ |
|
Definition
|
|
Term
Sulfonamides & Trimethoprim Use:
Wide use throughout world because cheap & effective
USA: less use because many resistant strains, allergic reactions, penicillins and other drugs to use
Most used is ____
Resistance developed:
(a) due to the ability of bacteria to ___ the drug
(b) to produce more ___ to counteract sulfonamide drug |
|
Definition
|
|
Term
| SMX-TMP is what type of drug? |
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
Term
| Co-trimoxazole is what type of drug? |
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
Term
| Bactrim is what type of drug? |
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
Term
| Septra is what type of drug? |
|
Definition
| Sulfamethoxazole + Trimethoprim |
|
|
Term
_____ is antibiotic used for Chronic and recurrent UTIs
_____ first choice for acute, uncomplicated UTI |
|
Definition
SMX-TMP
Fluoroquinolone (Cipro) |
|
|
Term
| Trimethoprim concentrates in ____ & ____ |
|
Definition
|
|
Term
| _______ is the antibiotic used for Acute gonococcal urethritis & oropharyngeal gonococcal inf. |
|
Definition
|
|
Term
| ________ is the antibiotic (drug of choice) for Pneumocystis carinii pneumonia ->Most common opportunistic fungus infections of AIDS |
|
Definition
|
|
Term
| ____ is the antibiotic used for GI infections & prophylaxis for travelers’ diarrhea -> E. coli, Proteus mirabilis, Salmonella typhi, Shigella |
|
Definition
|
|
Term
| _____ is the antibiotic used for Recurrent otitis media |
|
Definition
|
|
Term
| ____ is the antibiotic used for Nocardiosis |
|
Definition
|
|
Term
Sulfonamides & Trimethoprim Adverse Effects: Hypersensitivity
- Rashes common, angioedema, ____
- Many drugs are derivatives of sulfonamides, all these
can cause hypersensitivity reactions, e.g., diuretics
and sulfonylurea oral hypoglycemic agents
_____ in newborn
- Displaces bilirubin from albumin
- Contra-indicated if <__ months old, or __ at term ____________
- due to poor solubility of older sulfas
_____________
- In patients with G6PD deficiency |
|
Definition
Steven’s-Johnson syndrome
Kernicterus
2
pregnant
Crystalluria
Hemolytic anemia |
|
|
Term
| Ciprofloxacin (Cipro) is what type of drug? |
|
Definition
|
|
Term
| Norfloxacin is what type of drug? |
|
Definition
|
|
Term
| Ofloxacin is what type of drug? |
|
Definition
|
|
Term
| Levofloxacin is what type of drug? |
|
Definition
|
|
Term
| Enoxacin is what type of drug? |
|
Definition
|
|
Term
| Sparfloxacin is what type of drug? |
|
Definition
|
|
Term
| Lomefloxacin is what type of drug? |
|
Definition
|
|
Term
| Moxifloxacin is what type of drug? |
|
Definition
|
|
Term
| Trovafloxacin is what type of drug? |
|
Definition
|
|
Term
Fluoroquinolones Mechanism:
Inhibit _____ (_______)
Induces cleavage of ___
Bacterio____ |
|
Definition
DNA gyrase (topoisomerase II)
DNA
cidal |
|
|
Term
Fluoroquinolones Use:
Relatively non-toxic, well tolerated, ____ spectrum, excellent ____ bioavailability. |
|
Definition
|
|
Term
| Fluoroquinolone names all end in _____ |
|
Definition
|
|
Term
Fluoroquinolones Resistance:
Inappropriate overuse has led to increasing resistance. Don’t use for routine upper & lower ____ infections or ___ or ___ tissue infections
Mechanism: Mutated ____ or decreased permeability through ____ |
|
Definition
respiratory
skin
soft
gyrase
porins |
|
|
Term
Fluoroquinolones Spectrum:
Very ___ spectrum but generally more active against gram (__) than gram (__) aerobes
Not effective against ____ |
|
Definition
|
|
Term
Fluoroquinolones Pharmacokinetics:
Widely distributed in ___
Renal secretion of ____ drug in urine |
|
Definition
|
|
Term
| What antibiotic is used for Anthrax -> Bacillus anthracis? |
|
Definition
|
|
Term
Fluoroquinolones are used in ___ Tract & __ Tract Infections
Gram (-) rods E. coli, Enterobacter, Klebsiella pneumoniae, Proteus mirabilis, Serratia marcescens, Shigella, H. influenzae, Legionella, Pseudomonas aeruginosa
Gonorrhea Gram (-) cocci – alternate choice |
|
Definition
|
|
Term
| Fluoroquinolones have Good penetration into ____ |
|
Definition
|
|
Term
| What antibiotic is used for Resistant Respiratory Tract Infections -> Infections unresponsive to b-lactams? |
|
Definition
|
|
Term
| Fluoroquinolones are Not 1st choice for pneumonia because only ___ active vs. Strep. pneumoniae |
|
Definition
|
|
Term
Fluoroquinolones Adverse Effects:
_____ tolerated
Nausea, vomiting, diarrhea
Occasionally, headache, dizziness, rash, abnormal LFTs
May cause erosion of ____ leading to tendinitis and tendon rupture for older patients (>60 years old)
Use not recommended if <___ yr old
Contraindicated in ______ and nursing mothers |
|
Definition
Extremely well
cartilage
18
pregnant |
|
|
Term
| Metronidazole Forms cytotoxic compounds that damage ____ & ___ |
|
Definition
|
|
Term
| Metronidazole is what type of drug? |
|
Definition
| antibiotic that damages DNA |
|
|
Term
| Metronidazole is An anti-____ drug that also has potent antibacterial activity against ____, including Bacteroides & Clostridium |
|
Definition
|
|
Term
| Metronidazole is Well absorbed ___, well distributed including ___ |
|
Definition
|
|
Term
Metronidazole Adverse effect:
____-like effect (if ingested with alcohol) , blocks conversion of ethanol, acetaldehyde accumulates, flushing, nausea&ventilation
GI upsets, ____ taste |
|
Definition
|
|
Term
| Which antibiotic doesn't have resistance issues except w/ H. Pylori? |
|
Definition
|
|
Term
| What is the DOC for Amebiasis (E. histolytica)? |
|
Definition
| Metronidazole b/c is Antiprotozoal |
|
|
Term
| What is the DOC for Giardia? |
|
Definition
| Metronidazole b/c is Antiprotozoal |
|
|
Term
| What is the DOC for Trichomoniasis? |
|
Definition
| Metronidazole b/c is Antiprotozoal |
|
|
Term
Metronidazole Bacterial Uses:
____ or mixed intra-abdominal infections
____ (trichomonas, bacterial vaginosis)
Antibiotic-associated _________________
____ abscess
In combinations for ___________________ |
|
Definition
Anaerobic
Vaginitis
enterocolitis
Brain
Helicobacter pylori |
|
|
Term
| Rifampin is what type of drug? |
|
Definition
| antibiotic that Inhibits mRNA synthesis |
|
|
Term
Rifampin Inhibits DNA-dependent __________
Specific for _________
Resistance developed due to mutations in the ____ gene. |
|
Definition
RNA polymerase
prokaryotes
RNA polymerase |
|
|
Term
| Rifampin is Bacteri____ for intra- & extracellular mycobacteria including M. tuberculosis, M. leprae, and atypical mycobacteria. |
|
Definition
|
|
Term
Rifampin is the 1st line drug for _____
In combination with isoniazid, pyrazinamide, others |
|
Definition
|
|
Term
| Triple therapy for leprosy? |
|
Definition
| Rifampin, dapsone, clofazimine |
|
|
Term
| What antibiotic Discolors urine, tears, contact lenses? |
|
Definition
|
|
Term
| Mupirocin is what type of drug? |
|
Definition
| antibiotic -> Natural product produced by Pseudomonas fluorescenes |
|
|
Term
| Mupirocin is Active against gram (__) cocci including ___ |
|
Definition
|
|
Term
| Mupirocin is available in an _______ for local application |
|
Definition
|
|
Term
| Mupirocin Inhbits Staph. Isoleucyl ____ synthetase |
|
Definition
|
|
Term
| Nitrofurantoin is what type of drug? |
|
Definition
|
|
Term
Nitrofurantoin:
___ enzyme inhibitors
Used P.O. to treat GI infection (no ___ absorption)
Acts on ____ and ___ enteritis |
|
Definition
Multiple
systemic
bacterial
protozoal |
|
|
Term
| Antibiotics that are Protein Synthesis Inhibitors: (5) |
|
Definition
Tetracyclines
Aminoglycosides
Macrolides
Chloramphenicol
Clindamycin |
|
|
Term
| Doxycycline is what type of drug? |
|
Definition
|
|
Term
| Demeclocycline is what type of drug? |
|
Definition
|
|
Term
| Minocycline is what type of drug? |
|
Definition
|
|
Term
| Gentamicin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| tobramycin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| amikacin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| Neomycin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| Streptomycin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| Netilmicin is what type of drug? |
|
Definition
| Aminoglycoside antibiotic |
|
|
Term
| Erythromycin is what type of drug? |
|
Definition
|
|
Term
| Clarithromycin is what type of drug? |
|
Definition
|
|
Term
| Azithromycin is what type of drug? |
|
Definition
|
|
Term
| Chloramphenicol is what type of drug? |
|
Definition
| Antibiotic -> Protein Synthesis Inhibitors |
|
|
Term
| Clindamycin is what type of drug? |
|
Definition
| Antibiotic -> Protein Synthesis Inhibitors |
|
|
Term
Bacterial ribosomes differ from eukaryotic
Bacterial = __S with __S/__S subunits
Mammalian = __S with __S/__S subunits
Thus, antibiotics that bind and inhibit bacterial ribosome function have relatively selective toxicity for bacteria
____ ribosomes are more similar in bacteria and mammals
Toxicity of some of these drugs is at ___ ribosome |
|
Definition
70
50S/30S
80
60S/40S
Mitochondrial
mitochondrial |
|
|
Term
Tetracyclines (bacterio_____)
Binds to __S, block access of ____ |
|
Definition
|
|
Term
Aminoglycosides (bacteri____; very toxic)
Binds to __S , interferes with ____ of functional ribosome &/or ___ |
|
Definition
cidal
30
assembly
misreading |
|
|
Term
Macrolides (bacterio_____)
Bind irreversibly to __S, inhibits ____ |
|
Definition
|
|
Term
Chloramphenicol (bacterio_____)
Binds __S, inhibits ____ transferase reaction |
|
Definition
|
|
Term
Clindamycin (bacterio______)
Bind irreversibly to ___S, inhibits ____ |
|
Definition
|
|
Term
Tetracyclines Pharmacokinetics:
Adequate but incomplete ___ absorption
Absorption decreased by ....(4)
- Think antacids for PUD (Peptic ulcer disease), with
tetracycline for _____
- Concentrate in liver, kidney, spleen, skin & tissue
undergoing _____ (teeth, bone) or tumors with
high ____ (gastric carcinoma)
Do not give to ____
- Chelation with calcium discolors developing teeth
- Can reduce growth of developing bone |
|
Definition
oral
food, milk, cations, iron
H.pylori
calcification
calcium
children |
|
|
Term
Tetracyclines Clearance:
_____ uniquely cleared as chelate in feces
Others in ____ metabolism or ___ |
|
Definition
|
|
Term
| Tetracyclines Spectrum: very ____ |
|
Definition
|
|
Term
| Tetracyclines Especially useful for ... (3) |
|
Definition
| Chlamydia, Rickettsia, Mycoplasma |
|
|
Term
Tetracyclines Resistance: Sensitive bacteria have intake system to concentrate drug inside bacteria
Resistant bacteria have both intake and ___ systems and could not accumulate drug inside bacteria |
|
Definition
|
|
Term
Tetracyclines Side Effects:
Do not give to _____ –> teeth, bone
_____sensitivity
Superinfections with ____ -> (causes diarrhea and other intestinal disease when competing bacteria in the gut flora are wiped out by antibiotics.) -> (can be treated with oral ____ or ____)
Liver and kidney toxicity possible |
|
Definition
children
Photo
C. difficile
vancomycin
metronidazole |
|
|
Term
Tetracyclines Clinical Uses:
_____ infections
- Lymphogranuloma venereum – STD
- Psittacosis – pneumonia
_____
- Rocky Mountain Spotted fever from ticks
_____ - spirochete
- Lyme disease
_____
- Also erythromycin (is a macrolide)
_____ G(-) bacilli
- Vibrio cholerae – enterotoxin, diarrhea Doxycycline
_____ in combinations
Actinomyces, Amoebae |
|
Definition
Chlamydial
Rickettsia
Borrelia
Mycoplasma pneumonia (DOC)
Cholera
H. pylori |
|
|
Term
| Aminoglycosides are For aerobic gram ___ bacteria only |
|
Definition
|
|
Term
| Aminoglycosides enter through ____ then through active transport by ____ -dependent process. Low ____ & ___ inhibit transport. Transport enhanced by ___ damage to wall = synergistic effect |
|
Definition
porins
oxygen
pH & anaerobic
b-lactams |
|
|
Term
| Aminoglycosides are Effective against serious infection due to ___ gram(__) bacteria |
|
Definition
|
|
Term
Aminoglycosides Mechanism:
bacteri____, irreversible binding
Binds to ___S ribosomal subunit
blocks formation of _____ complex
____ of mRNA
Block ____ of mRNA chain |
|
Definition
cidal
30
initiation
Misreading
translocation |
|
|
Term
Aminoglycosides Resistance:
Bugs produce ___ that inactive drug
Impaired entry – mutant porin, or pH, O2
Mutant __S ribosomal protein |
|
Definition
|
|
Term
Aminoglycosides Pharmacokinetics:
Large, polar molecules
Poor ___ absorption
Must be given parenterally IM, IV, intrathecal if CSF
Distribution limited to _______
Do not reach ___
Eliminated by ____ filtration
Doses matched to creatinine clearance to avoid severe toxicity, blood levels monitored |
|
Definition
oral
extracellular fluid
CSF
glomerular |
|
|
Term
Aminoglycosides Adverse Effects
Very ____
___toxicity
- Loss of equilibrium
- Loss of hearing
____toxicity
____toxicity
____ blockade
- reduces respiratory function, esp. after surgery |
|
Definition
toxic
Oto
Nephro
Neuro
Neuromuscular |
|
|
Term
| Aminoglycosides are used for Gram (__) ___ bacteria, esp. when isolate is drug-resistant or sepsis |
|
Definition
|
|
Term
| Aminoglycosides Used in combo with ____, synergistic, extends spectrum to gram (__) |
|
Definition
|
|
Term
| Aminoglycosides used against Pseudomonas aeruginosa In combo with antipseudomonal _____ |
|
Definition
|
|
Term
| Aminoglycosides used for Enterococcal _____, Viridans streptococcal, & staph ____ |
|
Definition
|
|
Term
| Aminoglycosides used for _____ UTI, Not for ___, uncomplicated UTI |
|
Definition
|
|
Term
| Aminoglycosides are used for E. coli or Klebsiella pneumonia along With ____ & ____ |
|
Definition
| ampicillin & cephalosporin |
|
|
Term
| What is the 2nd line drug for TB? |
|
Definition
| Streptomycin (Aminoglycosides) |
|
|
Term
| Gentamicin is Active against Staph, coliforms, pseudomonas, proteus, Enterobacter, Klebsiella, Serratia, & other gram (__) ___ It is Mainly employed for severe infections, often ___ patient with bugs resistant to other antibiotics |
|
Definition
|
|
Term
Macrolides Mechanism:
Inhibits ____ synthesis
Binds irreversibly to __S, inhibits translocation of the peptidyl molecule from ”__” site to “__” site
Bacterio_____
Bacterio_____ at high concentrations |
|
Definition
|
|
Term
Macrolides Pharmacokinetics:
____ base is destroyed by stomach acid, so either enteric-coated or esterified forms given
____ & ____ stable to acid
All have adequate oral absorption
Distribute well to all tissues except __
Good levels in ___ and accumulates in ____ |
|
Definition
Erythromycin
Clarithromycin & azithromycin
CSF
prostate
macrophages |
|
|
Term
Macrolides Spectrum
Erythromycin spectrum same as Penicillin G so used often when Pt ____ to penicillin
Especially useful for (3)
Gram (__) organisms
- Pneumococci, streptococci, staphylococci,
corynebacteria
Aerobic Gram (__) & Others
- Mycoplasma, Legionella, Helicobacter, Chlamydia,
Listeria, Neisseria, Bordetella pertussis,
Treponema, some Rickettsia |
|
Definition
allergic
Chlamydia, Mycoplasma, Legionella
+
- |
|
|
Term
Macrolides: Clinical Use: Erythromycin (or other macrolide) = Drug of Choice (DOC) for:
______ pneumonia
- Spectrum includes pneumococcus, mycoplasma,
legionella
- Mycoplasma pneumonia “atypical pneumonia”
- Legionnaires’ Disease
______ infections during pregnancy
- Alternative to tetracycline for uncomplicated
urethral, endocervical, rectal or epididymal
Chlamydia infections
- Tetracyclines also effective
______
- Alternative if allergic to Penicillin G
______
- Erythromycin or Pen to eliminate carrier state
______
- UTI |
|
Definition
Community-acquired
Chlamydial
Syphilis
Corynebacterium diphtheriae
Ureaplasma |
|
|
Term
Clarithromycin is the DOC for ____ in combo with amoxicillin + PPI
Also active vs ______
Less GI upset than erythromycin
___ dosing vs. qid for erythromycin |
|
Definition
H. pylori
Haemophilus influenzae
BID |
|
|
Term
Azithromycin
___ dosing an advantage over other macrolides
Slightly better tissue penetration
Preferred for ___, also ___ |
|
Definition
Once-per-day
Chlamydia trachomatis
Haemophilus influenzae |
|
|
Term
Macrolides Adverse Effects:
____ distress common
Cholestatic _________
___toxicity – at high doses |
|
Definition
|
|
Term
| Macrolides Contraindication: patients with ___ dysfunction since drug ___ in liver |
|
Definition
|
|
Term
| Drug-drug interactions of macrolides: _____ & _____inhibit hepatic metabolism (by inhibiting cytochrome P450 enzymes) of theophylline, warfarin, and other drugs |
|
Definition
| Erythromycin & clarithromycin |
|
|
Term
| _____-____ is a combination of two streptogramins (30:70) for IV injection |
|
Definition
| Quinupristin-dalfopristin |
|
|
Term
| Streptogramins are Active against gram (__) ___including multidrug resistant Strep, pen resistant Strep. Pneuniae, methicillin- susceptible, and-resistant Staph, and vancomycin-resistant strain. |
|
Definition
|
|
Term
| Streptogramins Resistance is due to modification of (_____) drug-binding site |
|
Definition
|
|
Term
| Chloramphenicol is what type of drug? |
|
Definition
| antibiotic (protein synthesis inhibitor) |
|
|
Term
Chloramphenicol is ___ spectrum against G(+) & G(-) organisms
Even ___
but is ___ so use is restricted to life-threatening infections in which there are no alternatives |
|
Definition
|
|
Term
| Chloramphenicol Mechanism: Binds __S, inhibits ___ transferase reaction |
|
Definition
|
|
Term
| Chloramphenicol Resistance: Via increased metabolizing enzyme _______ |
|
Definition
|
|
Term
Chloramphenicol
IV or oral, enters CSF
Serious _____ [Rarely used]
Hemolytic anemia (G6PD deficiency)
aplastic anemia (fatal)
“___ baby syndrome” (cyanosis)
overgrowth of Candida |
|
Definition
|
|
Term
| Chloramphenicol Use: Life-threatening ___ or ___ infections |
|
Definition
Salmonella typhi
H. influenzae |
|
|
Term
Clindamycin Mechanism:
Bactericidal inhibition of ___ synthesis
Bind irreversibly to __S, inhibits translocation |
|
Definition
|
|
Term
| Clindamycin is used P.O. for treatment of ____ infections ex. Bacteroides fragilis |
|
Definition
|
|
Term
| Clostridium difficile is always resistant to ______ so for Incidences of pseudomembranous colitis (caused by C. difficile), treat with ____ or ____ |
|
Definition
Clindamycin
metronidazole or vancomycin |
|
|
Term
| _____ still the leading cause of death by infectious disease throughout the world |
|
Definition
|
|
Term
| Mycobacterium tuberculosis is Difficult to ___ & “____-___” |
|
Definition
|
|
Term
Tuberculosis Grows ____, treat for _ years
Many resistant strains so use multiple drug therapy |
|
Definition
|
|
Term
Mycobacterium tuberculosis
Treatment divided into:
1. Treatment of ___ infection diagnosed by a positive PPD or
2. Treatment of ___ clinical TB |
|
Definition
|
|
Term
Tuberculosis
First Line Drugs
1.
2.
3.
4.
5.
Second Line Drugs
Ethionamide, Aminosalicylic Acid, Capreomycin, Cycloserine |
|
Definition
1. Isoniazid
2. Rifampin (or Rifabutin)
3. Ethambutol
4. Pyrazinamide
5. Streptomycin |
|
|
Term
Tuberculosis FYI
Empirical initial therapy until susceptibility reports are available (4 drugs regimen)
1. Isoniazid (INH)
2. Rifampin (or Rifabutin)
3. Ethambutol
4. Pyrazinamide
Continuation phase: INH +rifampin for 4 months |
|
Definition
|
|
Term
Isoniazid (INH) in treatment of Tuberculosis:
Inhibits mycolic acid formation in outer membrane, this is unique to _____
INH acetylated in liver, “fast” acetylators have lower levels, “slow” acetylators may reach ____ levels
Side effects: peripheral neuritis, hepatitis, drug interactions |
|
Definition
|
|
Term
Rifampin in treatment of Tuberculosis:
Inhibits DNA-dep. ___ polymerase |
|
Definition
|
|
Term
| Pyrazinamide in treatment of ____: Drug targets and mechanism of action are unknown. |
|
Definition
|
|
Term
Ethambutol in treatment of tuberculosis:
Inhibits ___ acid synthesis, can impair ___ vision |
|
Definition
|
|
Term
Streptomycin in treatment of tuberculosis:
Parenteral, bacterio____ _____ synthesis inhibitor |
|
Definition
|
|
Term
Mavium complex bacteremia in AIDS patients can be treated with a single daily dose of ____ (300 mg)
_____, 500 mg once daily or ____, 500 mg twice daily ca also be used |
|
Definition
rifabutin
Azithromycin
clarithromycin |
|
|
