1. Phenoxybenzamine-- α1 and α2 
2. Phentolamine-----  α1
3. Prazosin----------- THE α1 Blocker
4. Terazosin----------
5. Doxazosin---------
6. Tamsulosin--------
7. Alfuzosin-----------
8. Silodosin----------  

Reserpine

 Act on peripheral Postganglionic sympathetic nerve endingsàdecreases the availability of the transmitter to the adrenergic receptors

Alphamethyldopa (methyldopa)

Clonidine

Guanabenz

Guanfacine

**All are Alpha2 Receptor Agonists

Non selective Alpha Adrenergic Blocker

• Long acting, Irreversible.  Non competetive. The only way to overcome is to synthesize new receptors
• used in severe hypertensive episodes from Catecholamine Release (Phechromocytoma)
• Long Term Treatment for Inoperable Pheochromocytoma
• Blocks both intra- and extrasynaptic alpha 2 receptors

Non Selective Alpha Adrenergic Blocker

• Short Acting, irreversible
• Used to diagnose Pheochromocytoma (give 5mg of this drug, if transient fall in BP, then positive result)
• Used during surgical removal of Pheochromocytoma to prevent rise in BP
• Used to reverse excess acute systemic vasoconstriction and hypertension
• prevents local tissue necrosis from an accidental injection of Alpha agonist
• New form (Oravers) to reverse numbing at dentist.

Selective alpha 1 adrenergic blocker