List the Beta-Adrenergic Blocking Agents

(Beta-Blockers)

Acebutolol

Atenolol

Esmolol

Metoprolol

Nadolol

Propanolol

Timolol

What beta blockers are cardio-selective?

Acebulolol

Atenolol

Esmolol

 Metoprolol

Which beta blockers are both beta1 and beta 2 blockers?

 (Non selective)

Nadolol

Pindolol

Propranolol

Timolol

Acebutolol

Pindolol

**Sometimes referred to as having Intrinsic Symp Activity (ISA)

Acebutolol

Proranolol

**Local Anasthetic Action.  Only seen at high concentrations

Which of the beta blockers have a high lipid solubility?

Medium solubility?

Low lipid Solubility?

High-Propranolol

Medium-Metoprolol, Pindolol

Low-Atenolol, Esmolol, Nadolol

High Lipid Solubility-->more likely to enter the brain and cleared by liver

Lower lipid solubility--> less likely to enter Brain, and will be excreted by kidneys

**Esmolol is short acting because it is rapidly inactivated by esterases

Labetalol 

• non selective B and selective A blocker
• used to treat moderate to severe primary hypertension (orally) and EMERGENCY treatment of hypertensive crisis (IV)
• Treatment caused arterial pressure to fall
• little aggravation of Raynaud's disease

• competetive antagonists for B1 receptors
• cardioselective- only block B1
• Nonselective-block B1 and B2 (relative term)
• At high doses, all beta blockers may block B1 AND B2.
• Intrinsic Sypmathetic and/or sympathomimetic activity (ISA)--> those that are also partial agonists
• Stabilize cell membrane-->local anasthetic
• high lipid solubility=enters brain, cleared by liver

Non selective Beta Blocker, and selective Alpha1-Blocker.

Treats Moderate-high Hypertension (Orally)

Treats emergency Hypertensive Crisis (IV)

Side effects: Alpha blockade (ortho. hypotension)

Beta blockade (bronchoconstriction)

LESS effect on Raynaud's Disease

LESS Tachycardia