Term
| all glucocoritocids and mineral coriocids appear to require for biologic activitiy |
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Definition
| 3 keto group, 4-5 double bond, and c-17 side chain |
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Term
| absolutly essential for glucorotiocoid receptor |
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Definition
|
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Term
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Definition
| c-1-2 double bond to prolong activity. 5x more active than cortisol. small amount of mineral corticoid action. |
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Term
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Definition
| powerful, has flourination and c-16 alpha methylation and c-1-2 double bond. 30x more potent by weight than cortisol. not serum bound. no mineral corticoid action |
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Term
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Definition
| non active pre cursors to steroids that are activated in liver. cant be used topically |
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Term
|
Definition
| 9-alpha-flourocortisol. used in low doses and in low doses is a mineral corticoid. |
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Term
|
Definition
| are the same in every tissue. cept estrogen. |
|
|
Term
| s-r complex entry to nucleus |
|
Definition
| mediated by phosphyorlyatinn dpendent on cyclases |
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|
Term
| steroid receptors modification |
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Definition
| are often post translationaly modified. |
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|
Term
| immediate effects of steroids |
|
Definition
| may be due to cell membrane interaction |
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Term
|
Definition
| usually means a loss of steroid receptors |
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Term
|
Definition
| usually due to affinity to SR |
|
|
Term
| duration matters in exposure to steroid before cushing syndrome |
|
Definition
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|
Term
| differences between natural versus iatrogenic cushings |
|
Definition
Greater freq in natural: irutism, virulaztion (androgen effects). infertility, hypertension, plethora, purple stria.
Specific to iatro genic:
glaucoma, benign intracranail hypertension, pancreatitis, aseptic necrosis of bone panicculaitis. |
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|
Term
| edema in mineralcorticoid use |
|
Definition
|
|
Term
|
Definition
| need to replace cortisone and mineral corticoid. |
|
|
Term
| acute adrenal insufficency |
|
Definition
| give massive amots of glucocorticoids, saline and glucose |
|
|
Term
| secondary adrenal insufficiency |
|
Definition
| -glucorticoids only. cept patho says different. |
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|
Term
| DHEA in women with hypoadrenalism. |
|
Definition
| not usually used. can give symptomatic releif |
|
|
Term
| counterindications to single dose of steroids |
|
Definition
|
|
Term
|
Definition
| allows recovery of acth pituitary axis yet still supresses inflammation |
|
|
Term
| steroid withdrawl syndrome |
|
Definition
| anorexia weight loss carpal tunnel syndrome, lethargy, low grade ferver myalgia and rash. normal in cushing syndrome curative surgery. absene is concerning in these patients. |
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Term
|
Definition
| anti fungal antibiotic. good for treating cushings inhibits andreanal enzymes that are needed for bio synth |
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Term
|
Definition
| inhibits formation of glucocorticoid, gluco coritocoid is inhibited. androgens and minearl corticoids not touched |
|
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Term
|
Definition
| related to insecticide. selctively toxic tocells of adreanl cortex. used to kill cells in adrenal cortical ca |
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Term
|
Definition
| anagonizes action of glucocorticoid by binding to receptors. can abort babes |
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Term
|
Definition
| competitive antagonist of aldosterone. caues gynecomastea. competitive antagonizes aldoesterone. good for primary hyperaldosteronism |
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Term
|
Definition
| endometriosis, sexual percocisty, prostate cancer |
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Term
|
Definition
| selective sterogen receptor modulator. either an anatagonist or agonist depending on locality. used for induction of ovulation |
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Term
|
Definition
| blocks negative feedback loop of estrogen, increasing LH and FSH. |
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