Term

Definition
plan for administration over a period of time
achievement of therapeutic level of the drug in blood without exceeding the minimum toxic concentration 


Term
define target plasma level 

Definition
guide dosage, able to determine if we can measure effect of the drug 


Term
how can you evaluate the effect of a drug that can't be measured 

Definition
pick a desired target (steady state) plasma level
compute dose to achieve that level
measure plasma levels of the drug
adjust dose as needed to get that level 


Term

Definition
adjust dose so rate of input equals rate of loss, keeps plasma level at target 


Term
calculation of maintience dose 

Definition
Dosing rate Ro = Css x CL/F F= bioavailability 


Term

Definition
initial dose to get drug to target level, can be a series 


Term
calculation of loading dose 

Definition
loading dose = Css x Vd/F 


Term
what is the steady state, what is the function 

Definition
ensures appropirate response to a drug given for long term therapy 


Term
how is steady state effected 

Definition


Term
how can you improve steady state 

Definition
give the drug more frequently 


Term
how is steady state related to half life 

Definition
double dose has higher steady state so the half life is the same as a lower dose
time to steady state is determine by half life
dose and how often dont help steady state
for every 1/2 life you get 1/2 the way to the goal of steady state
clinical steady state is 45 1.2 lives which is close enough to 100% 


Term
define therapeutic window and are the parts, define themm too 

Definition
useful opening between min theraputic concentration and min toxic concentration
through levels: determined by min effective concentration
peak plasma concentration: determine by min toxic concentration 


Term
what does a bad kidney do the clearance how do we adjust this 

Definition
renal disease or reduced CO reduces clearance 


Term
how is clearance calculated 

Definition
corrected dose = average dose x (creatine clearance / (100mL/min)) 


Term
equation for clearance not inthe kidney 

Definition
corrected dose = amt by non renal  amt by kidney x (creatine clearance / (100mL/min)) 

