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pharm - dementia/delirium 228
pharm t4
24
Pharmacology
Graduate
03/20/2010

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Cards

Term
pt can learn but wont remember unless prompted:
Definition
vascular dementia
Term
impaired learning and won't remember even when prompted:
Definition
AD
Term
beta amyloid plaques W/O neurfibrillary tangles:
Definition
Lewy Body Dementia
Term
dementia with extrapyramidal motor symptoms
Definition
lew body dementia
Term
visual spacial (drawing) and calculation spared
Definition
frontotemporal dementia
Term
visual spacial (drawing) and calculation ability hindered:
Definition
lewy body dementia
Term
AChEi: SE is hepatotox largely replaced by safer meds
Definition
Tacrine
Term
topical patch available may help w GI side effects:
Definition
rivastigmine
Term
NMDAi MOA:
Definition
blocks the action of excitatory nt glutamate.
Term
ADRs of NMDAi's
Definition
1. CNS
2. GI
3. CV
agitation, dysrrhythmias, tachy, HTN, constipation
Term
therapy for cognitive sx but reserved for severe dz:
Definition
NMDAi
Term
conditions medications that increase the risk for delirium:
Definition
D - drugs
E - eyes/ears
L - low O2
I - infection
R - retention
I - ictal
U - underhydrated/nutrition
M - metabolic
Term
drugs assoc w delirium:
Definition
1. AD (sep TCAs)
2. Antipsychotics
3. DA
4. opiods
5. BZO
6. corticosteroids
7. Lithium
8. EtOH withdrawal
9. anticholinergics
Term
antipsychotic causes agranulocytosis:
Definition
clozapine
Term
5 risks w chronic antipsychotic use:
Definition
1. sedation
2. anticholinergic effects
3. CV
4. dyskinesias
5. risk of sudden death doubles
Term
5 common ADRs of SSRIs:
Definition
1. HA
2. N/V/D
3. anxiety
4. serotonin syndrome
5. increasd risk of suicide in the elderly during the first month of therapy
Term
serotonin syndrome triad:
Definition
1. cognitive effects
2. autonomic effects (sweating, HTN)
3. somatic effects (myoclonua, hyperreflexia, tremor)
Term
4 SSRIs
Definition
1. paxil
2. prozac
3. effexor
4. remeron
Term
SSRI: most likely to raise BP
Definition
effexor
Term
SSRI: higher sedation at lower doses
Definition
remeron
Term
SSRI: long 1/2 life; may accumulate in elderly
Definition
Prozac
Term
SSRI: high anti-chol effects
Definition
Paxil
Term
2 heterocyclic ADs
Definition
BZO & non-BZO
Term
SE of BZO: 3
Definition
1. anterograde amnesia
2. paradoxical agitation
3. sedation
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