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Pharm Chapter 34
Drugs affecting the immune system
57
Nursing
Undergraduate 1
09/06/2011

Additional Nursing Flashcards

 


 

Cards

Term
T/F Rituximab should be used cautiously in patients with cardiac conditions
Definition
True
Term
T/F Retuximab does not have a high potention for infusion reactions
Definition
False
Term
As a precaution for allergic reactions, what agents should the nurse avoid during the first 2 hours of rituximab infusion?
Definition

a. Amphotericin

b. Blood products

c. first dose of antibiotics.

Term
T/F Rituximab can be use in children and pregnant and lactating mothers?
Definition
False, This drug is not recommended.
Term
Name 2 side effects or Rituximab,
Definition
Fever, chills and or headache.
Term

Rituximab is used for treatment of?

 

Definition
Non-hodgkin's Lymphoma
Term
Before administration, Rituximab is mixed with NS or what?
Definition
Dextrose solution.
Term
Should a nurse mix the Rituximab and NS in a plastic bag or a glass container? Why?
Definition
Plastic bag, the antibodies in the drug stick to the glass container.
Term
One of the nurses roles during Rituximab administration is to premedicate client with what?
Definition

a. Antihistamins

b. antipyretics.

Term
Whats an example of antihistamine might be administered as a premedication?
Definition

a. Ranitidine

b. diphenyhydramine

Term
What should the nurse do if the patient develops infusion related effects.
Definition
Stop the infusion till effects clear then start slowly.
Term
What can the nurse advise ambulatory clients to do when they arrive home after infusion.
Definition
Drink lots of luids to enhance renal excretion of tumor lysis products.
Term
What advise can the nurse give to a 25 year old female who planning to get married in a month?
Definition
Use birth control measures for 12 months.
Term
Again, the nurse should premedicate the patient with what?
Definition
Tylenol, and Antihistamines.
Term
What type of a drug is Trastuzumab (Herceptin)?
Definition
Humanized monoclonal antibody.
Term
Trastuzumab is used for what type of cancer?
Definition
Breast cancer.
Term
T/F Trastuzumab (Herceptin) administration starts with a loading dose.
Definition
True.
Term
The loading dose of Trastuzumab (Herceptin) is...
Definition
4mg/kg of body wt given over 90 mins.
Term
Whats the subsequent weekly dose of Trastuzumab (Herceptin)?
Definition
2mg/kg of body wt over 20 mins.
Term
Bevacizumab (Avastin) is a monoclonal antibody to target what?
Definition
Natural protein VEGF.
Term
What is VEGF?
Definition
A protein responsible for stimulation of new blood vessels.
Term
Whats the fancy name/word for Bevacizumab (Avastin)
Definition
Antiangiogenesis
Term
Whats one important thing should the nurse do during administration and why?
Definition
Cover the drug because its light sensitive.
Term

Below are some adverse effects. Choose all that apply to Bevacizumab (Avastin).

 

a. Asthenia

b. HA

c. HTN

d. anorexia

e. diarrhea

f. leukopenia

g. proteinuria.

Definition
All of the above.
Term
T/F Why should the nurse advise a surgery candidate to post pone surgeries while receiving Bevacizumab (Avastin)
Definition
Leukopenia is an know adverse effect.
Term
What type of a drug is Cetuximab (Erbitux)
Definition
Chimeric monoclonal antibody
Term
T/F Cetuximab (Erbitux) works by targeting EGRF sites
Definition
True
Term
T/F Cetuximab (Erbitux) also works by depriving both malignant and normal tissues of cytokines.
Definition
True (This enhances mutant cell death)
Term
Is Cetuximab (Erbitux) used to treat colorectal cancer or breast cancer.
Definition
Colorectal cancer.
Term
T/F Cetuximab (Erbitux) can be administered as a combo therapy. i.e. infusion and radiation.
Definition
True.
Term
A client is walks in for their Cetuximab (Erbitux) infusion but expresses concerns on how he will tolerate. What should the nurse say?
Definition
Cetuximab (Erbitux) is tolerated well by most people and that he will be closely monitored.
Term

What electrolyte imbalance may occur after within 2 weeks of Cetuximab (Erbitux) administration?

a. Hypocancemia

b. Hypokalemia

c. Hypomagnesia

d. Hypernatremia.

Definition
Hypomagnesia.
Term
T/F Panitumumab (Verctibix) is administered for coloretal cancer and its side effects as similar to cetuximab.
Definition
True
Term
Alemtuzumab (campath 1-H) is administered for what cancer?
Definition
Lymphocytic leukemia.
Term
T/F Alemtuzumab (campath 1-H) is administer by infusion for 2 hours QD untill toxicity is reached.
Definition
True.
Term
What should the nurse watch for in a client receiving Alemtuzumab (campath 1-H)?
Definition
Infusion allergic reactions.
Term
T/F Alemtuzumab (campath 1-H) may be administered sub Q
Definition
True. there is less frequent reactions.
Term
What lab is used to determine when to discontinue the therapy.
Definition
lymphocyte count
Term
Before a client is sent after therapy of Alemtuzumab (campath 1-H), its critical that they receive a .........treatment.
Definition
Antimicrobial prophylaxis.
Term
T/F Abciximab (ReoPro) is used to treat bone cancer.
Definition
False, this drug has no antitumor function.
Term
T/F Abciximab (ReoPro) inhibits platelet aggregation?
Definition
True
Term
Do immune modulator drugs act by stimulating or suppressing the immune system.
Definition
either
Term
Whats cyclosporine used for?
Definition
An adjunct treatment to prevent organ rejection.
Term
What are some factors that affect cyclosporin bioavailability?
Definition
Food, and enterohepatic circulation
Term
T/F Ingesting Cyclosporine with food hing in fat may increase bioavailability.
Definition
True
Term
T/F Cyclosporine is mainly excreted via the renal system.
Definition
False, Excreted is primarily biliary
Term

 

Does Cyclosoporing affects both humoral and cell-mediated immunity.

Definition
True
Term
T/F Pts taking cyclosporine at home should be advised to take the drug at the same time every day.
Definition
True
Term
Name one nursing dx for a pt receiving cyclosporine
Definition
Risk for infection r/t immunosuppression.
Term
T/F Pt. taking cyclosporine at home orally should use a class container to mix in a glass container.
Definition
True.
Term
Name an example of oral cyclosporine
Definition
Sandimmune
Term
Pts are allowed to mix sandimmune with orange juice or apple juice instead of water?
Definition
True, this improves the flavor.
Term

Which of the following is not an adverse effect of cyclosporine.

a. Renal dysfunction

b. Tremors

c. HA

d. HTN

e. Hirsutism

f. Gum hyperplasia

Definition
HA
Term
T/F Tacrolimus is closely related to cyclosporine
Definition
True.
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