Inhibitin microtubule synthesis; larvicidal and ovicidal effects

GI distress, alopecia, ↑liver enzymes, pancytopenia

Roundworms, tapeworms:

Hyadatid disease, cysticercosis, pinworm and hookworm, ascariasis, trichuriasis, strongylidiasis

Inhibits microtubule synthesis

GI effects, hypersensitivity (rash, uritcaria), agranulocytosis, alopecia, ↑liver enzymes

Roundworms:

Ascariasis, trichuriasis, hookworm and pinworm infections

Similar to other binzimidazoles (inhibit microtubules)

More toxic than other azole's

Neuropsych, irreversible liver failure, Stevens- Johnson  syndrome

Roundworms:

Strongyloidiasis, cutaneous larva migrans

Immobilizes microfilariae and alters their surface structure, displacing them from tissues and making them more susceptible to destruction by host defense mechanisms

Headache, malaise, anorexia,

weakness

Depends on organism

Filariasis, loiasis, tropical eosinophilia

Paralyze nematodes and arthropods by intensifying γ-aminobutyric acid (GABA)-mediated transmission of signals in peripheral nerves. Also microfilaricidal.

Fatigue, abdominal pain

Fever, somnolence, joint/muscle pain, tachycardia

Roundworms:

Strongyloidiasis, onchocerciasis

↑ permeability of trematode and cestode cell membranes to calcium, resulting in paralysis, dislodgement, and death

CNS (headaches, seizures),

myalgia, liver function, GI

Flukes, Tapeworms:

Schistosomiasis, H nana,

Neuromuscular blocking agent that causes

release of acetylcholine and inhibition of

cholinesterase. This results in paralysis,

which is followed by expulsion of worms.

Mild (nausea, vomiting,

diarrhea, etc.)

Roundworms:

Pinworm, ascaris, Trichostrongylus orientalis