Term
|
Definition
|
|
Term
|
Definition
HTN
CHF
in diabetic renal benifit |
|
|
Term
|
Definition
cough
angioedema: rapid sewlling of face after 1st dose |
|
|
Term
| contraindications of ACEI 1 |
|
Definition
|
|
Term
|
Definition
propranolol - no selective
desmolol, atenolol, metoprolol - B1 selective |
|
|
Term
| which BB are prefered in cardiac conditions |
|
Definition
|
|
Term
| contraindications to BB 3 |
|
Definition
asthma
diabetes
peripherial vascular disease: vasospastic angina |
|
|
Term
|
Definition
slows heart down
decreased CO
fatigue
never abruptly DC |
|
|
Term
|
Definition
HTN
CHF
anti-arrhythmic SVT class 2
angina |
|
|
Term
|
Definition
BB only used in arrhythmia
short t1/2 10 min |
|
|
Term
|
Definition
losartin
block ANG II receptor, benifits similar to ACEI |
|
|
Term
|
Definition
HTN
CHF
renal benifit in diabetes |
|
|
Term
|
Definition
|
|
Term
| contraindications of ARB 2 |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| vasodilates using NO with specificity for arterioles |
|
|
Term
|
Definition
| work through NO with sepcificity to VEINS |
|
|
Term
|
Definition
HTN
CHF - back up if unable to use ACEI/ARB |
|
|
Term
|
Definition
| drug most likley to cause drug induced lupus in slow acetylators |
|
|
Term
|
Definition
|
|
Term
|
Definition
main effect inside CNS
stimulates A2 inhibitory recetors decreasing sympathetic output |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| block PDE5 increasing cGMP and NO which causes vasodilation |
|
|
Term
|
Definition
pulmonary HTN
erectile dysfunction |
|
|
Term
| contraindications slidenafil |
|
Definition
| never use with nitrates, both work in same pathway too much dilation occurs |
|
|
Term
|
Definition
verapamil
diltaziam
amidopine |
|
|
Term
|
Definition
cardiodepressant
blocks L type Ca channels on heart |
|
|
Term
|
Definition
cardiodepressant
blocks L type Ca channels on heart mostly |
|
|
Term
|
Definition
vasodilates, drops BP
blocks L type Ca channels on vessels |
|
|
Term
|
Definition
HTN
angina
arrhythmia SVT class 4 |
|
|
Term
|
Definition
|
|
Term
|
Definition
HTN
angina
arrhythmia SVT class 4 |
|
|
Term
|
Definition
|
|
Term
|
Definition
reflex tachycardia
gingival hyperplasia |
|
|
Term
|
Definition
positive inotrope
inhibits Na/K ATPase on cardiac myosites
when Na goes up Ca does too and gets stored in sarcoplasmic reticulum so not it releases more causing positive inotropic effect |
|
|
Term
|
Definition
|
|
Term
|
Definition
low theraputic index
arrhythmia
blurry yellow vision |
|
|
Term
| contraindications of digoxin |
|
Definition
hypokalemia can enhance digoxin toxicity
digoxin and K bind same site on Na/K ATPase |
|
|
Term
| 4 drugs used for ventricular tachycardia |
|
Definition
procanamide
lodicaine
sotalol
amiodarone |
|
|
Term
| 4 types of drugs used for SVT |
|
Definition
|
|
Term
| 2 drugs used to ventricular tachycardia and SVT |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Procanamide: type, MOA, use |
|
Definition
1A
block Na and K
ventricular arrhythmia |
|
|
Term
| lidocainel type, moa, use |
|
Definition
1B
BB
ventricular arrhythmia |
|
|
Term
|
Definition
3
block K and BB
any arrhythmia |
|
|
Term
| amioderone: type, MOA, use |
|
Definition
3
block Na, K, Ca, BB
any arrhythmia |
|
|
Term
|
Definition
lupus in slow acetylators
torsades |
|
|
Term
|
Definition
|
|
Term
|
Definition
torsades - low risk
liver damage
pulmonary fibrosis
thyroid problems - due to iodine |
|
|
Term
|
Definition
stimulate adenosine receptors (Gi coupled so still inhibitory(
short half life 8s |
|
|
Term
| 2 Na channel blocker anti convulsants |
|
Definition
|
|
Term
|
Definition
Na channel blocker
glutamate inhibitor |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
teratogenic
gingival hyperplasia
p450 inducer
zero order kinetucs |
|
|
Term
|
Definition
|
|
Term
|
Definition
liver problems
hyperammonemia
teratogenic |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| DC if any sign of rash could be SJS |
|
|
Term
|
Definition
morphine
meperidine
buprenorphine |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
meiosis
depressed respiratory - fatal
decreased GI/GU
gall bladder spasms |
|
|
Term
|
Definition
decreased respiration
serotonin syndrome |
|
|
Term
|
Definition
| when you put it with a full Mu agonist it causes withdrawl |
|
|
Term
|
Definition
mu antagonist
IV antidote to quickly reverse opioid action |
|
|
Term
|
Definition
5HT1D agonist
vasoconstriction |
|
|
Term
|
Definition
|
|
Term
|
Definition
| venodilator decreases preload which decreases work on heart |
|
|
Term
|
Definition
angina SL for acute attack
not great preventitive |
|
|
Term
| drugs good vo vasospasm angina |
|
Definition
never BB
CCB vascular specific - amlodipine |
|
|
Term
| drugs good for stable angina prevention |
|
Definition
#1 is BB
any CCB will work (amlodipine, ditilzaim, verapmil) |
|
|
Term
|
Definition
| work on ascending loop of henle targeting Na/K/2Cl diuretic |
|
|
Term
|
Definition
loops loose Ca
ototoxic
K loss and thus H loss so metabolic acidosis |
|
|
Term
|
Definition
| DOC acute pulmonary edema |
|
|
Term
|
Definition
| works on DCT NaCl channels |
|
|
Term
| hydrochlorothiazide: SE 4 |
|
Definition
K loss and thus H loss so metabolic acidosis
thiazides save Ca
hyperglycemia |
|
|
Term
| hydrochlorothiazide: use 2 |
|
Definition
DOC daily fluid balance duiretic (long half life)
DI NOT caused by lithium |
|
|
Term
| what is used to tx DI caused by lithium, why |
|
Definition
| amularide: becaue lithium and Na are similar in size and charge. comes into CD through Na channels |
|
|
Term
|
Definition
works in CD as direct Na channel blocker
K sparing |
|
|
Term
| eplerone and spironolactone: MOA |
|
Definition
works in CD as ALD receptor blocker decreasing number of Na chennals, thus indirect CD blocker
K sparing |
|
|
Term
|
Definition
| if you save K you save H causing metabolic acidosis |
|
|
Term
|
Definition
lowers VLDL, TG
raises HDL |
|
|
Term
|
Definition
|
|
Term
|
Definition
bile acid sequesterant (ie cholesterol)
complexes with bile so you cannot recycle them and you loose them from the body and liver needs to make more bile acids and thus need to pull cholesterol from the blood to do it |
|
|
Term
| cholestyramine: contrindications, why |
|
Definition
| hyperTG patients: further increases TG because when liver starts making more bile acids it starts making other lipids too |
|
|
Term
|
Definition
HMG CoA reductase (rate limiting step in cholesterol synthesis) inhibitor
benifit all aspects of lipid profile |
|
|
Term
| which statin is most likley to raise HDL, which is least |
|
Definition
| atrivostatin > simvastatin |
|
|
Term
|
Definition
| muscle toxicity (myalgia, myositis, rhabdomyalgia) |
|
|
Term
|
Definition
| take with P450 inhibitor increases statin levels and risk of muscle toxicity (never drink grapefruit juice!) |
|
|
Term
|
Definition
| increases gene expression of PPARy which increases lipoprotein lipase which lowers TG |
|
|
Term
| what two NT and change in parkinsons disease |
|
Definition
decreased dopamine
increased ACh (Relative) |
|
|
Term
|
Definition
taken into CNS and turned into dopamine
use carbadopa to avoid DOPA decarboxylase break down in periphery |
|
|
Term
|
Definition
| dopamine agonist directly stimulates D2 receptors |
|
|
Term
|
Definition
| stops metabolism of dopamine by MAOB blocking it |
|
|
Term
|
Definition
in periphery and CNS levodopa is converted to 3-o-methyodopa by COMT
drug blocks COMT to increases levadopa conversion to dopamine |
|
|
Term
|
Definition
targets ACh, muscarinic blocker
lowers effect of ACh in parkinsons |
|
|
Term
|
Definition
|
|
Term
| drugs used for parkinsons |
|
Definition
levodopa/carbadopa
ropinerole
selegiline
entacapone
benzotropine |
|
|
Term
| explain the break down process of ethanol and the SE 3 |
|
Definition
| ethanol > alcohol DH > acetaaldehyde > aldehyde DH > acid aldehyde > acidosis, N/V, headache |
|
|
Term
| explain break down process of methanol and the SE 2 |
|
Definition
| methanol > alcohol DH > formeldahyde > aldehyde DH > formic acid > acidosis, eye damage |
|
|
Term
| explain break down process of ethylene glycol and the SE 2 |
|
Definition
| ethylene glycol > alcohol DH > aldehyde > aldehyde DH > acid aldehyde > acidosis, kidney damage |
|
|
Term
|
Definition
| blocks aldehyde DH causing aldehyde buildup which causes toxic effects deturing from alcohol use |
|
|
Term
|
Definition
methylphenidate
dextroamphetamine |
|
|
Term
|
Definition
| promote release of NE and dopamine |
|
|
Term
|
Definition
|
|
Term
|
Definition
tachycardia
sweating
increased BP |
|
|
Term
|
Definition
uses antithombin III to cleave IIa, IXa, XIa, XIIa
works on activated factors so works rapidly |
|
|
Term
|
Definition
protamine: directly complexes with heparin stopping its action
rapid onset |
|
|
Term
|
Definition
| heparin induced thrombocytopenia (stop all drugs working through antithrombin III if induced, not just heparin) |
|
|
Term
| how can heparin be monitered |
|
Definition
|
|
Term
|
Definition
| low molecular weight heparin |
|
|
Term
|
Definition
| takes time, decreased synthesis of II, IV, IX, X by stopping vitamin K |
|
|
Term
| warfarin antidote and MOA |
|
Definition
Vit K: never going to be fast
fresh frozen plasma: fast, replenishes clotting factors |
|
|
Term
| how is warfarin monitered |
|
Definition
|
|
Term
| rivaroxban: MOA, how monitored |
|
Definition
blocks factor Xa
no need to monitor |
|
|
Term
| dabigatran: MOA, how monitored |
|
Definition
direct thrombin inhibitor
no need to monitor |
|
|
Term
|
Definition
ADP receptor blocker
cannot activate platelets
good back up to aspirin |
|
|
Term
|
Definition
| glycoprotein IIb/IIIa inhibitor blocks fibrinogen receptors prevents cross linking in platelet aggregation |
|
|
Term
|
Definition
angioplasty
acute coronary syndromes
unstable angina |
|
|
Term
|
Definition
tPA
fibrinolytic
breaks down clots |
|
|
Term
|
Definition
|
|
Term
|
Definition
childhood leukemia
peds solid tumors (wilms)
rhabdomyosarcoma
ewings sarcoma
osteosarcoma
testicular cancer
chorioarcinoma
hodgkins lymphoma
some breast cancer |
|
|
Term
| 4 cancers that are malignant and difficult to cure |
|
Definition
| colon, lung, pancreas, late stage breast |
|
|
Term
| what are 4 characteristics of a tumor that show it will respond well to chemo |
|
Definition
fast growth
smaller
in growth stage (current proliferation)
areas of metastasis die easier |
|
|
Term
| how can you perdict the size of a tumor |
|
Definition
mass doubling is inversley proportional to growth fraction
tumors >1cm cause symptoms |
|
|
Term
| why do we do multiple rounds of chemo 2 |
|
Definition
to prevent resistance
pt may appear in remission because tumor decreased in size but it isn't gone |
|
|
Term
| why do we follow cancer surgery with chemo |
|
Definition
| chemo has a hard time penetrating large tumors, if there was tissue left it should be easily penetrated |
|
|
Term
| why do some tumors have necrosis and some dont |
|
Definition
diffusion of blood only goes 150um
some tumors are in steady state with a diffusion distance where rate of death equals rate of new cells
some outgrow their distance from the vessel and undergo necrosis
some make VEGF and produce their own vessels to avoid this problem |
|
|
Term
| explain the pattern in which cancer cells die |
|
Definition
killing is 1st order
prportion of cells die not a number |
|
|
Term
| how can you minimize cancer resistance to chemo |
|
Definition
| short term, intensive, intermittent, combination therapy |
|
|
Term
| what are some mechanisms of chemo resistance 3 |
|
Definition
change of target
drug penetration
drug efflux |
|
|
Term
| explain how chemo is effluxed, how can this be avoided |
|
Definition
P-glycoprotein Ca dependent ATPase pumps drug out
verapmil Ca channel blocker inhibits efflux |
|
|
Term
| what are commone side effects or toxicities of most cancer drugs 6 |
|
Definition
low theraputic index
vomiting
nausea
diarrhea
aloplecia
myelosupression |
|
|
Term
| what are 2 tumors caused by cancer treatment, how are they formed |
|
Definition
radiation often causes solid tumors
alkylating agents damage DNA in S phase leading to cancer in 10y, usually AML |
|
|
Term
| what are some patient criteria before they can begin cancer treatment 4 |
|
Definition
WBC > 3000
platelets > 100,000
assessment of renal and liver function |
|
|
Term
| explain the MOA of alkylation cancer drugs |
|
Definition
positive ion and carbonium ion covalently bind DNA/RNA on N7 and 2 guanine
cytotoxic effect stops DNA polymerase
(note: often mutagenic to DNA causing more cancer and not cell cycle specific) |
|
|
Term
| what are the alkylating agents |
|
Definition
low loved his mustangs, his car was a mustang. he declaired it's amazing, this is plastic, this is carbon plated, this is oxylate plated. Temara was so amazed. If only his family wasn't cyco all the time"
lowmustiing
carmusting
decarbazing
cysplastin
carboplastin
oxaloplastin
temaozolamide
ifosfamide
cyclophosphamide |
|
|
Term
| loumustine and carmustine: use |
|
Definition
| lipid soluble so good in brain |
|
|
Term
| loumustine and carmustine: SE |
|
Definition
| delayed marrow supression 4-6wk |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| cysplastin, carboplastin, oxaloplastin: how is the MOA different from the other alkylating agents |
|
Definition
| no carbonium ion, involves platinum |
|
|
Term
|
Definition
peripheral neuropathy
nephrotoxicity
ototoxicity
severe vomiting after 1h lasting 5d |
|
|
Term
|
Definition
marrow toxicity
peripheral neuropathi
ototoxicity
severe vomiting after 1h lasting 5d |
|
|
Term
|
Definition
peripheral neuropathy
nephrotoxicity
ototoxicity
marrow toxicity
severe vomiting after 1h lasting 5d |
|
|
Term
| what alkylating cancer drugs have a unique major limiting side effect, how is it avoided |
|
Definition
cysplastin, carboplastin, oxaloplastin: nephrotoxicity
TX: 1-2 L saline |
|
|
Term
|
Definition
|
|
Term
| ifosfamide and cyclophosphamide; how is the MOA different from other alkylating agents |
|
Definition
| P450 activations to carbonium which is converted to arcolem which can cause cystitis |
|
|
Term
| ifosfamide and cyclophosphamide SE and antidote |
|
Definition
hemorrhagic cystitis leads to fibrosis and blood in urine
MENSA: stops acrolein |
|
|
Term
| what do all the anti-metabolite cancer drug MOAs have in common |
|
Definition
| stops purine or primidine synthesis in S phase |
|
|
Term
| what are the anti-metabolite cancer drugs 6 |
|
Definition
he did his meth and trecked around, he put on his cap and sat behind the floral, carocel, and cirtus. he was in a bind, thio was only nine, in merca the pure
methotrexate
capeticapine
5-florouracil
citrabine
thioguanine
metacptopurine |
|
|
Term
| explain how thymine is made |
|
Definition
| dUMP + thymidine synthase -> dTMP -> thyamine |
|
|
Term
| explain how glycine is made |
|
Definition
methyl FH4 + (reaction to make thyamine) -> dihydrofolate
dihydrofolate + DHFR + folate -> tetrahydrofolate
tetrahydrofolate + serine -> glycine + methyl FH4 |
|
|
Term
|
Definition
| same a 5-FU but its a pro drug |
|
|
Term
|
Definition
| converted to 5-FdUMP which competes with dUMP for thymidine synthase inactivating it so dTMP isn't made and thymine isn't made |
|
|
Term
|
Definition
stops folate incorporation into DHFR so dihydrofolate cant be turned into tetrahydrofolate and glycine cannot be made
because this reaction stops so does the conversion of dUMP to dTMP ith thymidine synthase |
|
|
Term
| explain how uracial is made |
|
Definition
|
|
Term
|
Definition
| first converted to nucleotide, replaces with D-arabinose antagonizing |
|
|
Term
| explain how guanine and adenosine are made (non-salvage) |
|
Definition
ribose-1-P + PRPP synthase --> PRPP
PRPP + glutamite --> glutamate + IMP
IMP + GTP --> guanine
IMP + ATP --> adenosine |
|
|
Term
| explain how guanine and adenosine are made (salvage) |
|
Definition
| PRPP + HPRT --> IMP OR guanine |
|
|
Term
| MOA 6-mecaptopurine and 6-thioguanine |
|
Definition
stop denovo synthesis of purine ring by stopping HPRT in salvage pathway of guanine and adenosine synthesis
similar to AMP/GMP/IMP negative feedback |
|
|
Term
|
Definition
hepatic fibrosis
marrow toxicity |
|
|
Term
|
Definition
marrow toxicity
hand and foot disease: red desqumation of palms and soles |
|
|
Term
|
Definition
marrow toxicity
hand and foot disease: red desqumation of palms and soles |
|
|
Term
|
Definition
|
|
Term
| SE 6-mercaptopurine and 6-thioguanine |
|
Definition
| hyperuricemia: uric acid released from cells are they are lysed (esp in leukemia and lymphoma) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| methotrexate antidote: converted to methyl FH4 to restore DNA |
|
|
Term
|
Definition
| with combine wtih 5-FU is toxic |
|
|
Term
| what is the best way to administer 5-FU and why |
|
Definition
| with folate because it is more stable |
|
|
Term
| 6-mercaptopurine and 6-thioguanine drug interaction and why, what if they need to take it |
|
Definition
allopurinol: blocks xanthine oxidase which decreases metabolism of drug and causes chemo drug toxicity
if they have to take it reduce chemo by 75% strength |
|
|
Term
|
Definition
do the ox and Dan's ruby believe my sins? when i die i'll act on my sins
doxorubicin
danrubicin
bleomycin
diactinomycin |
|
|
Term
|
Definition
| most widley used and most important cancer drug |
|
|
Term
| what type of antitiobic are doxorubicin and danrubicin |
|
Definition
|
|
Term
|
Definition
inhibit topoisomerase II uncoiling and stopping DNA synthesis
P450 turns anthromycin to semiquinine (Fe ROS). it turns to superoxide and peroxide and breaks DNA
(Note: tissue is protected via superoxide dismutase and glutathione peroxidase except the heart |
|
|
Term
|
Definition
marrow toxicity
dose dependent cardiotoxicity (arrhythmia, edema, reduced EF and CO, cardiomyopathy) |
|
|
Term
|
Definition
antidote for anthrocycline
blocks Fe from drug
antidote for cardiac damage |
|
|
Term
|
Definition
| IN G2 forms ROS (Fe++ -> Fe+++ -> superoxide + hydroxide) which cause strand breaks |
|
|
Term
|
Definition
pulmonary fibrosis
mucocutaneous reaction |
|
|
Term
|
Definition
intercalator: inserts into DNA and complexes with G-C stopping RNA (and sometimes DNA) polymerase
also causes strand breaks |
|
|
Term
|
Definition
marrow toxicity
extravasion when injected (local toxicity) |
|
|
Term
| what phase do microtubule inhibitors work |
|
Definition
|
|
Term
|
Definition
vin was really blind but he blasted cristine's pack of taxes while she was doing her taxes
vinorelbine
vinblastin
vincristine
paclitaxel
docetaxel |
|
|
Term
| what are the 3 vinca alkaloids |
|
Definition
vinorelbine
vinblastin
vincristine |
|
|
Term
|
Definition
| blocks tubulin which blocks microtubule proliferation |
|
|
Term
|
Definition
marrow toxicity
aloplecia rare |
|
|
Term
|
Definition
SIADH
marrow toxicity
aloplecia rare |
|
|
Term
|
Definition
SIADH
peripheral neuropathy |
|
|
Term
|
Definition
|
|
Term
|
Definition
| reversibly bind tubulin, promote polymerization and stabilization and microtubules can't depolymerize so cell is stuck in M phase |
|
|
Term
|
Definition
hypersensitivity: chemophor EL has casteroil and absolute ethanol
marrow toxicity (esp neutropenia)
peripheral neuropathy |
|
|
Term
| how can you prevent taxane hypersensitivity |
|
Definition
dexamethasone
diphrenhydramine
cimetidine |
|
|
Term
|
Definition
he hand an episode with ten popsicles and asparagus. he wasnt hydrated and peed urea. so i treated trent's inion so he could go to Camp Tothecin where i ran to the top of the tecan mountain
etoposide
tenposide
L-asparaginase
hydroxyurea
trentinoin (ATRA)
irinotecan
Topotecan |
|
|
Term
| etoposide and tenposide MOA |
|
Definition
| blocks S-G2 by blocking topoisomerase II breaking DNA strands |
|
|
Term
| etoposide and tenposide SE 1 |
|
Definition
|
|
Term
|
Definition
| deaminates asparagine to asparatic acid and ammonia |
|
|
Term
|
Definition
hypersensitivity
marrow toxicity
hydroxylizes blood asparagine too |
|
|
Term
|
Definition
| ribonucleotide reductase inhibitor |
|
|
Term
|
Definition
|
|
Term
|
Definition
| binds RARa and promotes cell differentiation |
|
|
Term
|
Definition
retinoic acid syndrome: fever, respiratory distress, pleural effusions
marrow toxicity |
|
|
Term
| how to avoid retinoic acid syndrome |
|
Definition
| pretreat with dexamethasone before trentinoin use |
|
|
Term
| ininotecan and topotecan MOA |
|
Definition
|
|
Term
| ininotecan and topotecan SE |
|
Definition
|
|
Term
| what is the least toxic form of cancer therapy |
|
Definition
|
|
Term
| what is a clinical indication for steroid hormone cancer therapy |
|
Definition
| pallative unless a lymphoma |
|
|
Term
| what are 7 steroid hormone cancer drugs |
|
Definition
ana stared at leu who had a proglide. he was dexterous and handsome. she player her flute full of restraint as he tampered with the ox in the pan preoccupied with gettin some
anastrazole
leuprolide
dexamethazone
flutamide
fulvestrant
tamoxifen
prednisone |
|
|
Term
|
Definition
blocks aromatase which stops esterone conversion to estradiol
competitive inhibitor |
|
|
Term
|
Definition
| GNRH analog binds LHRH receptor in pituitary and desensitizes it which decreases FSH and LH and thus estrogen |
|
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Term
|
Definition
| binds glucacorticoid receptors increasing apoptosis and lymphocytes |
|
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Term
|
Definition
| competitive inhibitor of androgen receptors |
|
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Term
|
Definition
| inhibits estrogen binding, targets receptor for protesomal degradation |
|
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Term
|
Definition
| competitive inhibitor of estrogen receptors |
|
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Term
|
Definition
| binds glucacorticoid receptors increasing apoptosis and lymphocytes |
|
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Term
|
Definition
| estrogen dependent cancer |
|
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Term
|
Definition
| prostate cancer: with antiandeogen because it takes 1wk for receptors to down regulate and testosterone decreases so their could be a flare |
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Term
|
Definition
|
|
Term
|
Definition
| prostate cancer with GNRH agonist |
|
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Term
|
Definition
| estrogen positive breast cancer |
|
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Term
|
Definition
| estrogen positive breast cancer |
|
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Term
|
Definition
| leukemia and lymphoma (curative) |
|
|
Term
| general MOA of targeted anticancer drugs |
|
Definition
| target GF receptors disregulating cell signals causing defective DNA repair, apoptisis, tumor agenesis |
|
|
Term
| 6 targeted anticancer drugs |
|
Definition
im a tiny bored zombie, you bettwe be vaccinated for zombies because in thiland i reside. i see you tuck and hide. its a travesty, those zombies
imatinib
bortezomib
beavacizumab
thalidomide
cetuximab
trastuzumab |
|
|
Term
|
Definition
protein kinase inhibitor
stops BCR-ABL TK |
|
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Term
|
Definition
| reversible chymotrypsin inhibitor in proteasome stopping apoptosis |
|
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Term
|
Definition
| antibody to VEGFa blocks receptor stopping proliferation of endothelial cells and vessels |
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Term
|
Definition
| inhibits IL6 and TNFa decreasing angiogenesis |
|
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Term
|
Definition
| antibody to HER2 decreases TK which decreases angiogenesis, apoptosis, and metastasis |
|
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Term
|
Definition
CML (>90% remission)
TK tumors: GI, C-KIT |
|
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Term
|
Definition
|
|
Term
|
Definition
renal cell cancer
lung cancer
colorectal cancer
breast cancer |
|
|
Term
|
Definition
head SCC
neck SCC
colon cancer |
|
|
Term
|
Definition
| metastastic breast cancer |
|
|
Term
| what are 4 hematopoietic agents and what do they do |
|
Definition
erythropoetin: increases RBC
thrombopoietin: increases megakaryocytes which increases platelets
GM-CSF: increases neutrophils and monocytes
G-CSF: increases neutrophils |
|
|
Term
| what is GM-CSF synergistic with 6 |
|
Definition
| SCR, IL1, IL3, IL6, CFU-GM, CFU-MEG |
|
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Term
|
Definition
my cousin was late, she cycles for sport and takes glucocorticoids. she likes tacos within limits. i asked siri what the limits were
mycophenolate mofentil
cyclosporine
glucacorticoids
tacrolimus
sirolimus |
|
|
Term
| MOA mycophenolate mofetil |
|
Definition
non competitive inhibitor of inosme monophosphate DH of de novo guanine neculotide synthesis
prevents T and B cell proliferation |
|
|
Term
|
Definition
| binds cyclophilin and inhibits caleineruin (cytoplasmic phosphatase) stopping NFAT movement to mucleus and IL2 activation |
|
|
Term
|
Definition
inhibit NG-kG causing apoptosis
decrease IL1 and IL6
decrease T cell production of IL2 |
|
|
Term
|
Definition
| binds FKB-12 and inhibits calcineurin stopping NFAT movement to the nucleus and IL2 activation |
|
|
Term
|
Definition
binds FKB-12 and inhibits mTOR TK decreasing cell progression from G1-S
usually given with calcineurin inhibitor and steroid |
|
|
Term
| contraindications to sirolimus and why |
|
Definition
| never use in liver and lung transplant, can cause hepatic artery thrombosis and bronchial anastamotic dishiscence |
|
|
Term
| use mycophenolate mofetil |
|
Definition
|
|
Term
|
Definition
| transplant prophylaxis, RA, psoriases |
|
|
Term
|
Definition
| transplant prophylaxis, SLE, psoriasis, IBD, asthma, allergies |
|
|
Term
|
Definition
| transplant prophylaxis, RA, psorisis |
|
|
Term
|
Definition
transplant prophylaxis
other use in patients with renal issues |
|
|
Term
| SE mycopheolate mofetil 2 |
|
Definition
|
|
Term
|
Definition
nephrotoxicity
hyperlipidemia
gingival hyperplasia |
|
|
Term
|
Definition
nephrotoxicity
hyperlipidemia |
|
|
Term
|
Definition
hyperlipidemia
hepatic artery thrombosis
bronchial anastamotic dishiscence |
|
|
Term
| what cancer drugs do not cause marrow supression 5 |
|
Definition
hormones
asparaginase
bleomycin
vincristine
cisplastin |
|
|
Term
| what cancer drugs cause renal toxicity 3 |
|
Definition
cisplastin
nitrosureas
methotrexate |
|
|
Term
| what cancer drugs cause cardiotoxicity 2 |
|
Definition
|
|
Term
| what cancer drugs cause pulmonary toxicity 4 |
|
Definition
bleomycin
nitrosureas
methotrexate
busulfan |
|
|
Term
| what cancer drugs cause extravastion 2 |
|
Definition
|
|
Term
| what cancer drugs cause hypersensitivity 4 |
|
Definition
taxanes
asparaginase
etoposide
teniposide |
|
|
Term
| what cancer drugs cause peripheral neuropathy 3 |
|
Definition
vincristine
oxaloplatin
taxanes |
|
|
Term
| what cancer drugs cause hemorrhagic cystitis |
|
Definition
|
|
Term
| what cancer drugs cause liver toxicity |
|
Definition
|
|
Term
|
Definition
FDA DOES NOT REQUIRE PROOF OF EFFICACY, SAFETY, OR QUALITY CONTROL
FDA HAS TO PRROVE ITS UNSAFE RATHER THAN PROVE ITS SAFE
can claim to benifits but not cure
NCCAM oversees herbs not really FDA |
|
|
Term
| how patients think about herbs |
|
Definition
dont think doctors are for them
dont admit to talking them
dont realize 30% of drugs come from herbs |
|
|
Term
| possible harms of herbs and why |
|
Definition
if it has enough power to cause benifit it can cause harm
variability between manufactures, batches, plants, potency
additives may be added and not listed
wrong part of plant could be picked (belladona poisoning, digitalis poisoning)
can have heavy metals |
|
|
Term
| why herbs dont have much research |
|
Definition
controlled studies not profitable
studies not required
toxic effects seldom reported |
|
|
Term
| possible additives found in herbs that are dangerous |
|
Definition
pesticides
non declaired drugs
added chemicals
heavy metals: Pb, Ar, Cadmium, Cu, Me
prednisone
testosterone
diazepam |
|
|
Term
| garlic: MOA, uses 5, SE 1 |
|
Definition
allin > allicin (sulfur) > inhibits HMG-CoA reductase and TXA2
tx: hyperlipidemia, HTN, decreases LDL, TG, plaque
SE: ANTICOAGULANT, WATCH OUT WITH WARFARIN |
|
|
Term
|
Definition
in flavonoids, sequiterpenes, terpenes
IMPROVE COGNITIVE FUNCTION |
|
|
Term
|
Definition
activates NK cells and monocytes
INCREASE EFFECTS OF IMMUNE SYSTEM
HEPATOTOXICITY IF USED >8WKS |
|
|
Term
|
Definition
in protein, isoflavones, fiber, omega-6-FA
TX HYPERLIPIDEMIA (DECREASES TG, LDL, CHOLESTEROL) |
|
|
Term
|
Definition
5-A-REDUCTASE INHIBITOR
TX SYMPTOMS OF BPH |
|
|
Term
|
Definition
sapones called ginsenoides
TX FATIGUE |
|
|
Term
| st. johns wart: MOA, use, SE |
|
Definition
increases srtotonin
TX DEPRESSION
induces P450 |
|
|
Term
|
Definition
|
|
Term
|
Definition
valernic acid
IMPROVES SLEEP QUALITY |
|
|
Term
| glucosamine and chondroitin: sources, use, 3 benifits |
|
Definition
glucosamine is AA sugar
chondroitin is glycosaminoglycan
TX OSTEOARTHRITIS
DECREASES JOINT PAIN
INCREASES MOBILITY
INCREASES QUALITY OF LIFE |
|
|
Term
| creatinie: sources 2, use, 2 benifits |
|
Definition
made from flycine and arginine in urea cycle
in meat and fish
EXERCISE PERFORMANCE
INCREASES MUSCLE MASS
STRENGTH IN SHORT PERFORMANCE |
|
|
Term
|
Definition
|
|
Term
|
Definition
| gynecologic disorders: post menopause, menstural discomfort |
|
|
Term
|
Definition
| allergies, asthma, impotence |
|
|
Term
|
Definition
|
|
Term
|
Definition
heart diseae
heart failure |
|
|
Term
|
Definition
|
|
Term
|
Definition
| gynecological disorders: irregular mensturation, PMS |
|
|
Term
|
Definition
immune stimulant
antifertility |
|
|
Term
|
Definition
vericose veins
hemorrhoids |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
jet lag
sleep induction
cancer |
|
|
Term
|
Definition
|
|
Term
|
Definition
aphrodisiac
male impotence |
|
|
Term
| medicines derived from plants |
|
Definition
atropine
digoxin
cholchine
reserpine
quinine
vincristine
taxol
phygostigmine
ephedrine
cocaine
cslicylin
scopolamide
pnehylbutazone: NSAID, DC heavy metals
aminopyrine: NSAID, DC marrow toxicity |
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|
