Term
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Definition
False NTM, mimcis NE
stimulates central postsynaptic alpha2 receptors
decreases sympathetic tone, reducing CO,HR,BP,renin release
tx severe HTN in preeclampsia pregnancies
side efx: sedation, sleep disturbance, Na and H2O retention |
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Term
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Definition
Alpha2 agonist in RVLM
decreases PVR and reduces HR
also an analgesic
side efx: sedation, drowsiness, fatigue, anxiety, Na and H2O retention |
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Term
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Definition
Alpha2 agonist in RVLM
same effect as Clonidine
lowers plasma colesterol |
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Term
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Definition
Alpha2 agonist in RVLM
same effect as Clonidine, Guanabenz |
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Term
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Definition
Inhibits NE uptake into synaptic vesicles, essentially depleting NE
decreases sympathetic effects leading to decreased TPR, CO, renin release, and BP
contraindicated in pts with gastric ulcers or depression |
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Term
| Phenoxybenzamine (Dibenzyline) |
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Definition
nonselective Alpha receptor blocker
obsolete for HTN tx but used for BP control in pheochromocytoma |
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Term
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Definition
| Selective Alpha1 receptor blocker tx of HTN short-acting so gradually increase dose to prevent postural HTN increases HDL and improves insulin resistance side efx: dizziness, vertioo, drowsiness, palpitations, HA, retain Na and H2O |
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Term
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Definition
Alpha1 specific receptor blocker
tx HTN and BPH (prostate enlargement)
side efx: orthostatic hypotension |
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Term
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Definition
Alpha1 specific receptor blocker
tx HTN and BPH (prostate enlargement)
side efx: orthostatic hypotension |
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Term
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Definition
nonselective Beta-blocker
decreases CO, HR, Contractility, and inhibits reflex tachycardia
anti-arrhythmic due to membrane stabilizing
tx HTN |
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Term
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Definition
nonselective Alpha and Beta blocker
tx HTN
First choice for treating CHF |
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Term
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Definition
nonselective beta-blocker
also has intrinsic sympathetic activity so less drastic decrease in CO and HR |
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Term
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Definition
nonselective beta-blocker
also has intrinsic sympathetic activity so less drastic decrease in CO and HR |
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Term
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Definition
nonselective beta-blocker
very slight intrinsic sympathetic activity |
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Term
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Definition
| nonselective beta blocker |
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Term
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Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN |
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Term
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Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN |
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Term
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Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN
long-acting |
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Term
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Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN
long-acting |
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Term
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Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN
short-acting, used to tx tachycardia |
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Term
|
Definition
selective Beta1-blocker
can be used in asthmatics due to selectivity
tx HTN
can increase vasodilation due to increased NO production |
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Term
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Definition
Direct Vasodilator
relaxes arteriolar smooth muscle by opening K/ATP channels
side efx: reflex tachycardia and powerful activator of renin release
used as Rogaine for baldness |
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Term
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Definition
Direct Vasodilator
prodrug for NO which relaxes smooth muscle cells to dilate both arteries and veins
inceased cGMP leads to decreased TPR and decreased afterload
tx HTN crisis and left-sided heart failure
side efx: hypotension, tachycardia, palpitations |
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Term
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Definition
Direct Vasodilator
relaxes arteriolar smooth muscle, increases HR and contractility, causes venoconstriction
tx CHF
side efx: flushing, HA, tachycardia, palpitations |
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Term
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Definition
Direct Vasodilator
opens K channels in smooth muscle
tx HTN crisis
effect is augmented with beta-blocker to prevent reflex tachycardia
side efx: Na and H2O retention, tachycardia, palpitations, hyperglycemia |
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Term
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Definition
Direct Vasodilator
D1 receptor agonist, short half-life
tx HTN crisis, contraindicated for glaucoma
side efx: reflex tachycardia and IOP |
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