Term
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Definition
C.A. inhibitor that works at PCT
bicarbonate is lost in urine, Chlorine is reabsorbed instead. Diuresis and natriuresis
treats glaucoma, cysteinuria, manages seizures
side effects: metabolic acidosis, hypercholremia |
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Term
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Definition
Loop Diuretic that works by inhibiting the Na/K/2CL symporter
Greatly increases diuresis, natriuresis, K/Mg/Ca excretion
Treats pulmonary edema, HTN, hypercalcemia, prophylactic renal failure
Side effects: Increase BUN, hyopkalemia, alkalosis, ototoxicity, interacts with Warfarin |
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Term
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Definition
Loop Diuretic that inhibits Na/K/2CL symporter in TALH
40x more potent than Lasix with no Warfarin interaction |
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Term
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Definition
Loop Diurectic
Longest half-life |
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Term
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Definition
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Term
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Definition
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Term
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Definition
Osmotic Diuretic that works in the PCT
inert drug that is not metabolized, increases urinary flow by 10x because it increases osmolarity
used as prophylactic treatment for renal failure due to trauma or shock that causes low GFR
Side effects: increases ECV which can cause heart failure |
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Term
| Hydrochlorothiazide(Esidrex) |
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Definition
Class I Thiazide that works in DCT by inhibiting Na/Cl symporter in the Na-K-aldosterone independent segment
Increases diuresis, natriuresis, K excretion, and vasodilation, decrease CO and BP due to volume loss
Treats HTN, edema from CHF, liver and renal failure, nephrogenic Diabetes Insipidus
Side effects: hypokalemia, hyperlipidemia, hyperuricemia, hypercalcemia, hypo-Mg, fever, rash |
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Term
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Definition
Class I Thiazide
treats HTN and is long-acting |
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Term
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Definition
Class I Thiazide
treats HTN |
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Term
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Definition
Class II Thiazide
increased potency, Tx HTN even with renal insufficiency |
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Term
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Definition
Class II Thiazide
most potent thiazide, treats HTN and causes vasodilation |
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Term
| Spironolactone(Aldactone) |
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Definition
K-sparing Diuretic working in the DCT
Aldosterone antagonist by competitively inhibiting Aldosterone
Inhibits Na reabsorption in late DCT
causes increased diuresis and natriuresis but hyperkalemia so used with Thiazide
treats edema, CHF, hyper-aldosteronism, K depletion
Side effects: gynecomastia, hirsutism, uterine bleeding |
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Term
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Definition
K-sparing Diuretic in the DCT
Aldosterone antagonist
same tx as Aldactone |
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Term
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Definition
K-sparing diuretic
blocks K secretion in late DCT
Inhibits Na reabsorption in the late DCT
used with a thiazide
increases natriuresis, diuresis, hyperkalemia so used with thiazide
treats edema, CHF, hyper-aldosteronism, K depletion |
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Term
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Definition
K-sparing Diuretic in the DCT
blocks K secretion in late DCT
treats edema, CHF, hyper-aldosteronism, K depletion |
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Term
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Definition
Anti-Diuretic Hormone that works in the Collecting Ducts
works as vasoconstrictor at V1 receptor
activates aquaporin to increase H2O reabsorption at V2 receptor |
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Term
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Definition
Anti-diuretic working in the Collecting Duct
works at V2 receptor to increase aquaporin
Treats central diabetes insipidus and bleeding |
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Term
| Demeclocycline(Declocyclin) |
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Definition
Diuretic that antagonizes ADH at the V2 receptors
treats Syndrome of Inappropriate Secretion of ADH
(SISADH) |
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