Shared Flashcard Set

Details

Pharm Arthritis Gout
Upstate Pharmacology Arthritis and Gout
17
Medical
Graduate
11/13/2010

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Cards

Term
Indomethacin, Naproxin
Definition
NSAID
Term
Celecoxib
Definition
COX2
Term
Prednisone
Definition
Glucocorticoid, used to initiate therapy
Term
Hydroxychloroquine
Definition
Decreases Tcell activation
Term
Sulfasalazine
Definition
inhibits IL1 and TNF-α release
Term
MTX
Definition
DMARD, gold standard
Term
Leflunomide
Definition
DMARD, inhibits DHODH
Term
Etanercept
Definition
BRM, TNF-α Receptor-like protein
Term
Infliximab
Definition
BRM, Chimeric (mouse), antibody to TNF-α
Term
Adalimumab
Definition
BRM, Fully-human antibody to TNF-α
Term
Anakinra
Definition
BRM, IL1 Receptor antagonist
Term
Abatacept
Definition
BRM, Reduces Tcell activation/Incrases Tcell apoptosis
Term
Tocilizumab
Definition
BRM, IL6 receptor antagonist
Term
Rituximab
Definition
BRM, anti-CD20, reduces Bcells
Term
Colchicine
Definition
Gout, prevents tubulin polymerization --> reduces pain and inflammation fast
Term
Probenecid
Definition
Gout, uricosuric agent, organic acid competes with urate for reabsorption
Sfx: GI irritation, low urate can induce acute gout, reduced secretion of penicillin
Term
Allopurinol
Definition
Gout, Xanthine oxidase competitive inhibitor (alloxanthine non-competitive inhibitor)
Sfx: acute attacks of gout possible initially, urate mobilized from tissues
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