Term
| 6 indications for use of antidepressants in axiety disorders: |
|
Definition
1. OCD
2. Panic do
3. Social anxiety do
4. generalized anxiety
5. separation anxiety
6. PTSD |
|
|
Term
| explain the lag time assoc w antidepressants and snxiety d/o's |
|
Definition
- 2-4wks or longer in generalixed anxiety
- 8-12wks in panic d/o
- >8wks in social anxiety (full benefit may not be seen until 12wks) |
|
|
Term
| 3 adverse effects of SSRIs: |
|
Definition
1. CNS - insomnia, akathisia (RLS), agitation
2. GI (N,V,D)
3. Sexual dysfunction |
|
|
Term
| 2 syndromes assoc w SSRIs: |
|
Definition
1. SSRI discontinuation syndrome: flu-like sx & electrical sensations
2. Serotonin syndrome: hyperthermia, myoclonus, Mental status changes, HTN |
|
|
Term
| first line agent for generalized anxiety d/o: |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
1. panic disorder
2. generalized anxiety do |
|
|
Term
|
Definition
1. anticholinergic (constipation, dry mouth blurred vision)
2. sedation
3. weight gain
4. orthostatic hypotension
5. sexual dysfunction
6. potentially fatal in overdose |
|
|
Term
| class of RX for clomipramine: |
|
Definition
|
|
Term
| Clomipramine's role in therapy: |
|
Definition
| useful for OCD as a second line behind SSRIs |
|
|
Term
|
Definition
|
|
Term
|
Definition
1. refractory panic d/o
2. 2nd line social anxiety
3. PTSD
4. insomnia, nightmares, flashbacks |
|
|
Term
|
Definition
1. interactions assoc w aged/fermented products
2. weight gain
3. CV effects |
|
|
Term
| well tolerated and effective TETRAcyclic antidepressant for the tx of PTSD: |
|
Definition
|
|
Term
|
Definition
1. weight gain
2. drowsiness |
|
|
Term
| BZO role in anxiety d/o's |
|
Definition
| offer immediate relief - use when urgent response needed |
|
|
Term
| BZO effect on generalized anxiety disorder: |
|
Definition
| BZOs reduce somatic and autonomic sx but don't reduce xs worry |
|
|
Term
| BZOs place in long term care for anxiety: |
|
Definition
| use is short term (1-2wks) while waiting for other maintenence agents to kick in. |
|
|
Term
| Rx that is the best choice for situational anxiety: |
|
Definition
|
|
Term
|
Definition
1. cognitive impairment
2. CNS depression
3. additive sedation w other sedatives
4. disinhibition
5. dependence/withdrawal |
|
|
Term
| withdrawal sign/sx from BZO |
|
Definition
1. anxiety
2. insomnia
3. restlessness
4. agitation
5. muscle tension
6. irritability
7. seizures |
|
|
Term
|
Definition
1. valium
2. librium
3. klonopin
4. tranxene |
|
|
Term
|
Definition
1. serax
2. xanax
3. ativan |
|
|
Term
| which is more likely to produce withdrawal sx, short or long acting BZOs? |
|
Definition
|
|
Term
| role in therapy for busprione: |
|
Definition
| for generalized anxiety disorders; non-habit forming/no withdrawal sx |
|
|
Term
|
Definition
|
|
Term
| buspirone does not work for: |
|
Definition
1. depression
2. panic d/o
3. phobias
4. OCD |
|
|
Term
| buspirone may require up to ___wks for effectiveness: |
|
Definition
|
|
Term
|
Definition
1. dizziness
2. nausea
3. HA
4. nervousness
5. dysphoria |
|
|
Term
| agents worsening anxiety disorders: |
|
Definition
1. caffeine
2. stimulante meds (decongestants, ritalin)
3. diet teas
4. many herbal substances |
|
|
Term
| 4 "alternative agents" for the tx of anxiety: |
|
Definition
1. B-blockers
2. antihistamines
3. antipsychotics
4. moodstabilizers |
|
|
Term
| first line therapy in PTSD |
|
Definition
| mood stabilizers:VPA, carbemazepine, lithium |
|
|
Term
|
Definition
| orthostaic hypotension and bradycardia |
|
|
Term
|
Definition
| drowsiness, anticholinergic SE |
|
|
Term
| antipsychotics role in anxiety therapy |
|
Definition
| augmentation for refractory OCD & combined with other therapies n PTSD + psychosis, parinoia, hypervigilance |
|
|
