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Pharm - antiinflammatory - test 1
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28
Pharmacology
Undergraduate 2
09/13/2011

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Term
mast cells
Definition
release histimine when allergen is encountered
Term
antihistimines
Definition
block histamine at H1 receptor, to stop allergy response
Term
Allergies, motion sickness, insomnia
Definition
antihistimines are used to treat (3)
Term
Dimetapp, Tavist, Benadryl, Actifed
Definition
4 types of generation 1 antihistimines
Term
Zyrtec, Claritin, Allegra, Clarinex
Definition
4 types of 2nd generation antihistimines
Term
dry mouth
Definition
antihistimes cause ____ _____
Term
hypoglycemia
Definition
antihistimines can cause _________ in diabetic patients
Term
retentions
Definition
antihistimes promote urinary __________
Term
Intranasal Glucocorticoids
Definition
Steroids for the nose, applied direct to nasal passages
- very few side effects compared to oral
Term
1-4
Definition
Intranasal Glucocorticoids may be used _____ times per day as directed
Term
Sympathomimetics
Definition
Stimulates sympathetic nervous system to treat allergies and cold s/s
Term
Afrin, Neo- synephrine, Sudafed
Definition
three types of sympathomimetics
Term
rebound congestion
Definition
problem with intranasal sprays
Term
oral and intranasal
Definition
routes available for Sympathomimetics (Afrin, Neo- synephrine, Sudafed)
Term
hypertension, insomnia, CNS stimulation
Definition
side effects of oral Sympathomimetics
Term
Systemic glucocorticoids
Definition
Naturally released by adrenal cortex
Suppresses histamines and prostaglandins, thereby reduces immune system inflammation
Term
Systemic glucocorticoids
Definition
"...one" . Prednisone, betamethasone, cortisone, hydrocortisone, methylprednisolone, triamcinolone
Term
alternate days
Definition
if long term glucocorticoid treatment is needed, the patient will most likely need to ______ ______
Term
Suppression of normal function adrenal glands:
Hyperglycemia
Mood changes/irritability, hyperactivity
Cushing's syndrome
Cataracts
Peptic ulcers
Electrolyte imbalances
Osteoporosis
Thinned skin/mucous membranes/alveolar membranes
Can mask acute infection
Definition
side effects of glucocorticoids
Term
cushing syndrome
Definition
moon face - osteoperosis- mood change - cardiac hypertrophy, buffalo hump
Term
tapered off
Definition
when ending tx, glucocorticoids must be ______ _____
Term
Immunostimulants
Definition
Natural chemicals that boost the immune system
Term
Interferon - Interleukins
Definition
two types of immunostimulants
Term
interferons
Definition
slow spread of viruses and enhance WBC activity (leukemia, AIDS, Hepatitis B & C)
Term
interleukins
Definition
boost the entire immune system (renal cancer, stimulates platelet production in CA pts.)
Term
immunosuppressants
Definition
Given to decrease immune response, usually with organ transplants to avoid rejection of new implanted tissue
Term
Imuran, Cyclosporine, Methotrexate, Cellcept, Rapamune
Definition
5 immunosuppressants
Term
Decreased renal function and renal flow

Must monitor kidney function lab test

Tremors

Hypertension

Elevated liver enzymes

Risk of infection/bleeding when WBC count <4,000 or platelets <75,000

Protect the liver from other damaging drugs, may have to hold those if liver damage occurs
Definition
adverse effects of immunosuppressants
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