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Pharm - anticoag - test 2
a
39
Pharmacology
Undergraduate 2
10/12/2011

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Term
anticoagulants
Definition
drugs that prevent clot formation
Term
antiplatelets
Definition
drugs that prevent platelet aggregation
Term
thrombolytic
Definition
drugs that eliminate clots
Term
coumadin
Definition
PO drug that interferes with specific vit K dependant clotting factors
Term
Heparin
Definition
IV drug that inhibits formation of fibrin clots (turns off clotting pathways)
Term
LMWH (lovonox)
Definition
SubQ drug that produces a very stable response for anticoagulation with less chance of bleeding than heparin
Term
protamine sulfate
Definition
antidote for heparin and LMWH
- given IV over 10 minutes
Term
drop in BP and pulse
Definition
when giving protamine sulfate (Heparin and LMWH antidote) the nurse should watch for
Term
vitamin K - whole blood - platelets
Definition
antidote for warfarin (coumadin)
Term
1.5 - 2.5
Definition
for Heparin, clotting time should be _____ faster than control time
Term
APTT (activated partial thromboplastin time)
Definition
lab test used to check clotting factors in IV or SC Heparin
Term
1.5 - 3
Definition
for LMWH (lovonox), clotting time should be _____ faster than control time
Term
1.5 - 3
Definition
for Warfarin (coumadin), clotting time should be _____ faster than control time
Term
INR
Definition
lab test used to check clotting factors in Lovonox
Term
INR and PT
Definition
lab tests used to check clotting factors in warfarin (coumadin)
Term
ticloplidine (Ticlid)
Definition
preferred antiplatelet - prolongs bleeding time
Term
eptifibatide (intergrillin)
Definition
antiplatelet used to treat unstable angina acute coronary syndrome
Term
fibrolytic
Definition
another name for thrombolytics
Term
plasmin
Definition
thrombolytics convert plasminogen to ________ which prevents tissue necrosis
Term
plasmin
Definition
enzyme that breaks up clots when thrombolytics are used
Term
alteplase recombinant (Activase)
Definition
preferred thrombolytic
Term
6 hours - 3 hours
Definition
activase(thrombolytic) must be given within ____ of an MI and ____ of thrombotic stroke
Term
daily
Definition
Heparin doses are adjusted _____, based on APTT
Term
heparin
Definition
when beginning treatment, a loading dose of _______ may be given, followed by warfarin
Term
3 months
Definition
postop anticoagulant therapy may last up to ________
Term
extra pressure for 30 minutes - bandages
Definition
inverventions for bleeding at IV site with anticoagulants
Term
vitamin K
Definition
with anticoagulants, pt should limit food high in ___________
Term
1 week
Definition
antiplatelets should be stopped ______ prior to surgery
Term
ACE inhibitors
Definition
preffered type of drugs for hypertension
Term
ace inhibitors
Definition
drugs that supress the renin-angiotensin system. Stop Angiotensin I to Angiotensin II so Na and water are excreted = decrease BP
Term
ARBs (angiotensin II receptor blockers)
Definition
drugs that stop the binding of angiotensin II at receptor sites
Term
nitroprusside
Definition
IV drug given for hypertensive crisis
- no time to wait for PO to work
Term
ulcers, GI upset, anorexia, constipation
Definition
GI adverse effects of ACE inhibitors
Term
Rash, pertusis, cough, dry mouth, tahycardia, hypotension, neutropenia
Definition
non-GI adverse effects of ACE inhibitors
Term
edema, H/A, flushing, nausea, constipation, nervousness
Definition
non-cardiac adverse effects of Ca channel blockers
Term
bradycardia, hypotension, arrhythmias
Definition
cardiac adverse effects of calcium channel blockers
Term
hypotension, upper respiratory symptoms, cough
Definition
adverse effects of ARBs (angiotensin receptor blockers)
Term
verapamil (Ca channel blocker)
Definition
antihypertensive that should be given with food
Term
ARB's
Definition
these antihypertensive drugs can not be taken by someone who is pregnant or may become pregnant
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