Term
| Examples of Signaling Inhibitors |
|
Definition
-Cyclosporine
-Tracolimus
-Sirolimus |
|
|
Term
|
Definition
Inhibits Calcineurin
lowers production of IL2 |
|
|
Term
| What are signaling inhibitors used for |
|
Definition
|
|
Term
| Adverse Effects of Cyclosporine |
|
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts |
|
|
Term
| Special feature of Cyclosporine |
|
Definition
| Made organ transplant possible |
|
|
Term
|
Definition
FKBP protien
same as cyclosporine |
|
|
Term
|
Definition
Inhibits mTOR
inhibits translation and
causes cells to arrest in G1 phase |
|
|
Term
| Adverse Effects of Cyclosporine |
|
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts |
|
|
Term
| Special feature of Cyclosporine |
|
Definition
| Made organ transplant possible |
|
|
Term
|
Definition
FKBP protien
same as cyclosporine |
|
|
Term
|
Definition
Inhibits mTOR
inhibits translation and
causes cells to arrest in G1 phase |
|
|
Term
|
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts |
|
|
Term
|
Definition
Hyperlipidemia
NO TUMOR formation effect |
|
|
Term
| Example of Corticosteroid |
|
Definition
|
|
Term
|
Definition
| Inhibits cytokine production (IL-1) |
|
|
Term
|
Definition
|
|
Term
| Prednisone Adverse Effects |
|
Definition
|
|
Term
| Examples of Proliferation Inhibitors |
|
Definition
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil |
|
|
Term
Action of
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil |
|
Definition
| Inhibit T-cell proliferation |
|
|
Term
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
Adverse Effects |
|
Definition
|
|
Term
Rh(D) Immunoglobulin action
(RHOGAM) |
|
Definition
| Prevents development of antibodies from Rh- mom after pregnancy with Rh+ baby |
|
|
Term
| Rh(D) Immunoglobulin Limitation |
|
Definition
| Won't work if mother has already developed Rh(D) antibodies |
|
|
Term
| Muromonab-CD3(QKT-3) Action |
|
Definition
Binds CD3 on suface of T-cells
Inhibits I-cell activation |
|
|
Term
|
Definition
| Acute Transplant Rejection |
|
|
Term
Anti-IL-2-Receptor Antibody Action
(Daclizumab) |
|
Definition
| Binds IL-2 receptor activation = blocked T-cell activation |
|
|
Term
| Anti-IL-2-Receptor Antibody Use |
|
Definition
| Acute Transplant Rejection |
|
|
Term
|
Definition
| Chimeric monoclonal antibody against CD20 B-cell antigen |
|
|
Term
|
Definition
Relapsed indolent Lymphomas
Rheumatoid Arthritis w/ methotrexate
Maybe MS |
|
|
Term
|
Definition
| Chimeric anti-TNF-a neutralizing antibody |
|
|
Term
|
Definition
Rheumatoid Arthritis (w/ methotrexate)
-for pts refractory to methotrexate alone |
|
|
Term
|
Definition
| Chimeric anti-IL-6 receptor neutralizing antibody |
|
|
Term
|
Definition
|
|
