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Pharm 5-Immunopharmacology
Pharm exam 5
32
Pharmacology
Professional
12/05/2012

Additional Pharmacology Flashcards

 


 

Cards

Term
Examples of Signaling Inhibitors
Definition
-Cyclosporine
-Tracolimus
-Sirolimus
Term
Cyclosporine Action?
Definition
Inhibits Calcineurin
lowers production of IL2
Term
What are signaling inhibitors used for
Definition
Tx Cancer
Term
Adverse Effects of Cyclosporine
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts
Term
Special feature of Cyclosporine
Definition
Made organ transplant possible
Term
Tracolimus Action
Definition
FKBP protien
same as cyclosporine
Term
Sirolimus Action
Definition
Inhibits mTOR
inhibits translation and
causes cells to arrest in G1 phase
Term
Adverse Effects of Cyclosporine
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts
Term
Special feature of Cyclosporine
Definition
Made organ transplant possible
Term
Tracolimus Action
Definition
FKBP protien
same as cyclosporine
Term
Sirolimus Action
Definition
Inhibits mTOR
inhibits translation and
causes cells to arrest in G1 phase
Term
Tracolimus SEs
Definition
Nephrotoxicity,
Hepatotoxicity
Neurotoxicity
Inc. tumor formation, esp in organ trans pts
Term
Sirolimus adverse
Definition
Hyperlipidemia
NO TUMOR formation effect
Term
Example of Corticosteroid
Definition
Prednisone
Term
Prednisone action
Definition
Inhibits cytokine production (IL-1)
Term
Prednisone Use
Definition
Tx Cancer
Term
Prednisone Adverse Effects
Definition
Insomnia,
Hypomania
Ulcers
Term
Examples of Proliferation Inhibitors
Definition
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
Term
Action of
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
Definition
Inhibit T-cell proliferation
Term
Cyclophosphamide
Methotrexate
Mycophenolate Mofetil
Adverse Effects
Definition
Myelosuppresion
Term
Rh(D) Immunoglobulin action
(RHOGAM)
Definition
Prevents development of antibodies from Rh- mom after pregnancy with Rh+ baby
Term
Rh(D) Immunoglobulin Limitation
Definition
Won't work if mother has already developed Rh(D) antibodies
Term
Muromonab-CD3(QKT-3) Action
Definition
Binds CD3 on suface of T-cells
Inhibits I-cell activation
Term
Muromonab-CD3(QKT-3) Use
Definition
Acute Transplant Rejection
Term
Anti-IL-2-Receptor Antibody Action
(Daclizumab)
Definition
Binds IL-2 receptor activation = blocked T-cell activation
Term
Anti-IL-2-Receptor Antibody Use
Definition
Acute Transplant Rejection
Term
Rituximab action
Definition
Chimeric monoclonal antibody against CD20 B-cell antigen
Term
Rituximab Uses
Definition
Relapsed indolent Lymphomas
Rheumatoid Arthritis w/ methotrexate
Maybe MS
Term
Infliximab Action
Definition
Chimeric anti-TNF-a neutralizing antibody
Term
Influximab Uses
Definition
Rheumatoid Arthritis (w/ methotrexate)
-for pts refractory to methotrexate alone
Term
Tocilizumab Action
Definition
Chimeric anti-IL-6 receptor neutralizing antibody
Term
Tocilizumab Uses
Definition
Rheumatoid Arthritis
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