Term
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Definition
opioid receptor antagonist
used for rapid detox for heroin
used to reduce the reward of alcohol |
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Term
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Definition
relapse prevention for alcoholics
blocks acetaldehyde dehydrogenase
results in flushing HA, N/V, dysphoria |
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Term
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Definition
| benzo used for alcohol detox |
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Term
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Definition
| antiseizure used for alcohol detox |
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Term
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Definition
| opioid receptor agonist, used for heroin addiction, transfer dependence to methadone |
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Term
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Definition
atypical antidepressant
stabilize dopamine levels following tobacco withdrawal |
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Term
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Definition
nicotinic receptor partial agonist
reduce dopamine elevation (reduce reward for smoking ) |
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Term
| clozapine, quetiapine, olanzapine |
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Definition
2nd generation
MOA: blocks D2 receptor, blocks serotonin receptors
effects: positive, negative, & cognitive sx |
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Term
| haloperidol, fluphenaxine, chlorpromazine |
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Definition
1st generation
MOA: D2 receptor antagonists
effects: positive sx |
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Term
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Definition
MAOB selective inhibitors
clinical use: monotherapy or in comno w/ L-DOPA, may slow progression of parkinsons |
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Term
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Definition
muscarinic antagonist
clinical uses: useful in tx of tremors
use limited by bad ADRs |
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Term
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Definition
D2 like receptor agonist
clincial use: used as early monotherapy or adjunctive therapy w/ LDOPA |
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Term
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Definition
glu receptor antagonist
MOA: blocks both indirect & direct pahtways
clincial use: reduces tremor in early dz, reduce LDOPA induced dyskinesias |
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Term
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Definition
| crosses BBB, effective in reducing all sx pf parkinsons, low PO bioavailability, converted to dopa in periphery, degraded by COMT |
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Term
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Definition
| given w/ LDOPA, blocks conversion to dopamine in periphery & brain |
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Term
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Definition
| administered w/ LDOPA to stop COMT degradation, prolongs effect of LDOPA, useful against on/off syndrome, mall allow reduction in dose of levodopa |
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