Term
|
Definition
MOA – limit leukos and macros
- inhibit PLA2 and COX2
--> lower prostaglandin
SE – long term: cushings,
osteoporosis, infections, ulcers
uses – allergic, hemato, hepatic, and collagen disorders |
|
|
Term
|
Definition
MOA – limit leukos and macros
- inhibit PLA2 and COX2
--> lower prostaglandin
SE – long term: cushings,
osteoporosis, infections, ulcers
uses – allergic, hemato, hepatic, and collagen disorders |
|
|
Term
|
Definition
MOA – antimetabolite
- signal 3 inhibitor
- cell-cycle specific (S-phase)
- inhibits purine synthesis
– suppresses T-cells more than B-cells
SE – N/V, marrow suppression, infection
- contraindicated in pregnancy
uses – immunosuppression for renal grafts, RA |
|
|
Term
|
Definition
MOA – antimetabolite
- signal 3 inhibitor
- cell-cycle specific
- inhibits Dihydrofolic acid reductase
- inhibits purine synth --> inhibits DNA synth
- MOA in RA unknown
***LEUCOVORIN – “rescues” normal cells not already given lethal DNA damage
- reduces dihydrofolate reductase inhibition in normal cells
SE – N/V, marrow suppression
- HEPATOTOXICITY
- renal toxicity, COPD
uses – Chrohns, RA, JRA, antineoplastic |
|
|
Term
|
Definition
MOA – alkylating agent
- signal 3 inhibitor
- NOT cell-cycle specific
- Inhibits B and T cells
SE – N/V, marrow supression, aspermia
uses – RA, leukemia and other tumors |
|
|
Term
|
Definition
MOA – purine synth inhibitor like Azathioprine (signal 3)
- inhibits IMP-Dehydrogenase (last step of guanosine synth)
- hydrolyzed to MPA, a reversible inhibitor
SE – GI, neutropenia, infection
uses – immunosuppression in grafts |
|
|
Term
|
Definition
MOA – Calcineurin phosphatase inhibitor
- signal 1 inhibitor
- T-cell suppressor
SE – Nephrotoxicity, HTN, Embryotoxicity
uses – immunosuppression for grafts |
|
|
Term
|
Definition
MOA – murine monoclonal Ab IgG blocks TCR/CD3
- blocks Signal 1
- T-cell suppressor
SE – fever/chills, sensitivity for murine products
uses – immunosuppression for grafts: renal, liver |
|
|
Term
| Lymphocyte Immune Globulin |
|
Definition
– antithymocyte globulin
MOA – horse immuune globulin against human thymus tissue
- signal 1
- T-cell suppressor
SE – fever/chills, sensitivity for equine serum
uses – renal transplant rejection |
|
|
Term
|
Definition
MOA – IgG for IL-2 receptor on surface of activated lymphocytes
- 90% human, 10% murine
- signal 3 inhibition
- T-cell inactivation
SE – GI probs
uses – renal transplant rejection |
|
|
Term
| Rho Immune Globulin (RhoGam) |
|
Definition
Ab immunosuppressive
MOA – human Ig for Rho antigen
- binds Rho in Rho-neg mothers so they won’t form immune response to it
- signal 1
SE – mild; not for use by Rho-pos pts
uses – prevent Rho- mothers from responding to Rho+ babies |
|
|
Term
|
Definition
Replacement therapy
MOA – broad IgG and IgM against bacterial, viral, parasitic, mycoplasmic
SE – mild
uses – hypogammaglobulinemia, HIV, ITP, Guillain-Barre |
|
|
Term
|
Definition
Immunomodulator
MOA – Anti-viral and immunoregulatory
SE – flu, depression/suicide, injection-site reaction
uses – MS: relapsing-remitting |
|
|
Term
|
Definition
Immunomodulator
MOA – activates phagocytes, Ab-dependent cytotoxicity
SE – flu sx
uses – Chronic granulomatous disease, Osteoporosis |
|
|
Term
|
Definition
Salicylic Acid Derivative
MOA - IRREVERSIBLE inhib of COX-1,COX-2
SE - GI, liver, hypersensitivity, Reyes, salicylism
uses - pain, fever, inflamm,rheumatism |
|
|
Term
|
Definition
Salicylic Acid Derivative
-not true salicylate
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI mild, HA, renal, hypersenstvty
uses - pain, inflamm, weak fever |
|
|
Term
|
Definition
Acetic Acid Derivatives
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI severe, gestation prolonged, renal, HA and depression
uses - NOT Juvenile RA |
|
|
Term
|
Definition
Acetic Acid Derivatives
MOA - more COX-2 inhibition
SE - GI less severe |
|
|
Term
|
Definition
Acetic Acid Derivatives
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI, dizzy and HA |
|
|
Term
|
Definition
Acetic Acid Derivatives
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI, HA, anaphylaxis
uses - Juvie RA especially |
|
|
Term
|
Definition
Acetic Acid Derivatives
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI, HA
uses - moderately severe acute pain |
|
|
Term
|
Definition
Propionic Acid Deriv
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - mild GI, Ocular, hypersensitivity, pregnancy
uses - typical |
|
|
Term
|
Definition
Propionic Acid Deriv
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - mild GI, mild HA, hypersenstvty
uses - Juvie RA |
|
|
Term
|
Definition
Propionic Acid Deriv
MOA - REVERSIBLE inhib of COX-1, COX-2
SE - GI, HA
uses - typical |
|
|
Term
|
Definition
Propionic Acid Deriv
MOA - REVERSIBLE inhib of COX-1, COX-2
- ONCE DAILY
SE - GI
uses - RA, osteoarth |
|
|
Term
|
Definition
Enolic Acid Derivative
MOA - REVERSIBLE inhib COX-1, COX-2
SE - GI
uses - RA, osteoarth |
|
|
Term
|
Definition
Enolic Acid Deriv
MOA - more COX-2 selectivity
SE - GI
uses - osteoarth |
|
|
Term
|
Definition
Alkanone
MOA - more COX-2 selectivity, activated by liver
SE - GI, HA
uses - RA, osteoarth |
|
|
Term
|
Definition
MOA - COX-2 inhibitor only
SE - mild GI CNS resp rash allerg
uses - typical + dysmenorrhea, familial adenomatous polyposis |
|
|
Term
|
Definition
MOA - Antipyretic by hypothal action
- weak inhibition of COX-1, COX-2
SE - minor. hepatotox and nephrotox
uses - antipyretic, analgesic duh |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
| adrenergic bronchocilators |
|
|
Term
|
Definition
Methylxanthine Bronchodolators
-cause bronchodilation and inhibit release of mediators from mast cells
-narrow theraputic window |
|
|
Term
|
Definition
Methylxanthine Bronchodolators
-cause bronchodilation and inhibit release of mediators from mast cells
-narrow theraputic window |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Leukotriene Modulators
-slow mediators of anaphylaxis |
|
|
Term
|
Definition
Leukotriene Modulators
-slow mediators of anaphylaxis |
|
|
Term
|
Definition
Leukotriene Modulators
-slow mediators of anaphylaxis |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
| (Salmeterol & Fluticasone) |
|
|
Term
|
Definition
| (Ipratropium & albuterol) |
|
|
Term
|
Definition
| (Formoterol & Budesonide) |
|
|
Term
|
Definition
| (Formoterol & Mometasone) |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
-stimulate glucose production and release: adequate supply to brain
-save sodium, pee potassium
-incrse RBCs & PMNs, decrease othr WBCs
-reduce inflamm, supress cytokines, etc
-influence mood and sleep
USES
-allergic disorders, cerebral edema, bact meningitis, SLE/collagen disorders, hemolytic anemia, ITP, liver disease, renal disease, respiratory
SE
-GI, edema, lipidemia, hypoK, hypoPHos, osteonecrosis, negative N balance, CNS edema, growth stunting, myopathy, skin thinning, Cushing's, ocular, infections, HPA suppression, withdrawal |
|
|
Term
| Mineralocorticoids (aldosterone) |
|
Definition
| save Sodium, pee Potassium |
|
|
Term
|
Definition
Glucocorticoid
short-medium acting
-anti-inflammatory, Ulcerative Colitis |
|
|
Term
|
Definition
Glucocorticoid
short-medium acting
uses: everything |
|
|
Term
|
Definition
Glucocorticoids
intermediate acting
-allergy, asthma, etc, etc |
|
|
Term
|
Definition
Glucocorticoid
long acting
-primarily anti-inflamm, immunosuppress |
|
|
Term
|
Definition
Glucocorticoid
short-medium acting
-respiratory |
|
|
Term
|
Definition
| Glucocorticoid synthesis inhibitor |
|
|
Term
|
Definition
| Glucocorticoid synthesis inhibitor |
|
|
Term
|
Definition
Mineralocorticoid (aldosterone)
-save Sodium, pee Potassium
-treat Addison's
-fluid retention |
|
|
Term
|
Definition
ACTH-dependent Cortisol Hypersecretion
-Cushings DISEASE
-tumor in pituitary
ACTH-dependent Cortisol Hyper: Ectopic
-ACTH-secreting tumor in lung, etc.
ACTH-independent Cortisol Hyperscrtn
-adrenal adenoma |
|
|
Term
| Diagnosis of Adrenal Glucocorticoid Hypersecretion |
|
Definition
low-dose dexamethasone: test for Cushings: reduction in cortisol reveals normal HPA axis function
high-dose dexamethasone: test for ECTOPIC Cushings |
|
|
Term
|
Definition
Mineralocorticoid antagonist
-competes with aldosterone
-normalize [K] before surgery for hyperaldosteronism |
|
|
Term
|
Definition
synthetic ACTH
MOA - stimulates adrenal cortex
uses - diagnostic test for primary vs secondary adrenal insufficiency |
|
|
Term
| Drug interaction of antihistamines |
|
Definition
| Terfenadine or Astemizole reacts with Erythromycin, Ketoconazole, or Itraconazole producing life threatening torsades de pointes |
|
|
Term
|
Definition
| very sedating Antihistamine |
|
|
Term
|
Definition
very sedating Antihistamine
Anti-emetic |
|
|
Term
|
Definition
| very sedating Antihistamine |
|
|
Term
|
Definition
sedating Antihistamine
Anti-emetic |
|
|
Term
|
Definition
sedating Antihistamine
Anti-emetic |
|
|
Term
|
Definition
|
|
Term
|
Definition
sedating Antihistamine
Anti-emetic |
|
|
Term
|
Definition
| non-sedating H1 Antagonists |
|
|
Term
| Certirizine, Levocetirizine |
|
Definition
| non-sedating H1 Antagonists |
|
|
Term
|
Definition
| non-sedating H1 Antagonists |
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
Anti-emetic
Anti-cholinergic |
|
|
Term
| Prochlorperazine (compazine) |
|
Definition
Anti-emetic
Dopamine antagonist |
|
|
Term
|
Definition
Anti-emetic
Dopamine antagonist |
|
|
Term
|
Definition
Anti-emetic
5-HT antagonist |
|
|
Term
|
Definition
Anti-emetic
5-HT antagonist |
|
|
Term
|
Definition
Anti-emetic
5-HT antagonist |
|
|
Term
|
Definition
|
|
Term
|
Definition
Anti-emetic
new P/neurontin antagonist |
|
|
Term
|
Definition
| Anti-tussive for severe cough |
|
|
Term
|
Definition
Anti-tussive
non-opioid for mild or moderate cough |
|
|
Term
|
Definition
Anti-tussive
local anesthetic and desensitizes airway receptors |
|
|
Term
|
Definition
Anti-tussive
acts on airway receptors |
|
|
Term
|
Definition
Anti-tussive
expectorant - increases mucus production in airway |
|
|
Term
| acetylcysteine (Mucomyst) |
|
Definition
Anti-tussive
mucolytic
ALSO the antidote for acetaminophen toxicity |
|
|
Term
| Inflammatory mediators of RA |
|
Definition
cytokines
TNF-a
IL-1
IL-6
leukotrienes
prostaglandins
histamine
serotonin
proteases
platelet-activating factor
complement cleavage products |
|
|
Term
| Neutrophils in RA release... |
|
Definition
lysosomal enzymes
toxic O2 metabolites
arachidonic acid cascade products |
|
|
Term
| Hydroxychloroquine sulfate |
|
Definition
Non-biologic DMARD - 2nd line drug
MOA - unknown
SE - Ocular toxicity irreversible
uses - also SLE and antimalarial |
|
|
Term
|
Definition
Non-biologic DMARD - 2nd line drug
MOA - immunosuppressive, affinity for connective tissue
SE - neutropenia reversible, also GI sx
uses - |
|
|
Term
|
Definition
Non-biologic DMARD - 2nd line drug
MOA - inhibits pyrimidine synthesis
SE - Hepatotox, immunosuppression, hypersensitivity rash and alopecia |
|
|
Term
|
Definition
Biological DMARD
MOA - binds alpha AND BETA TNF
- TNF receptor hinged to Ab Fc
SE - hypersensitivity, infection
uses - RA, JRA, combo w methotrexate |
|
|
Term
|
Definition
Biologic DMARD
MOA - only binds ALPHA TNF (not BETA)
- murine-human Ab
SE - hypersensitivity,immunosuppression
uses - RA, Crohn's, use w methotrexate |
|
|
Term
|
Definition
|
|
Term
|
Definition
Hyperthyroidism
MOA - radioactive, kills thyroid tissue |
|
|
Term
|
Definition
Hyperthyroidism
MOA - inhibits TH synthesis |
|
|
Term
|
Definition
Hyperthyroidism
MOA - inhibits TH synthesis |
|
|
Term
|
Definition
Hyperthyroidism
MOA - inhibits TH synthesis by overloading Iodide transporter |
|
|
Term
|
Definition
1. Thionamides - stop synth of new TH
2. KI - halt release of stored TH
3. Propranolol – block b-adrenergic receptors
4. glucocorticoids – inhibit deiodinase |
|
|
Term
|
Definition
PTH increases active metabolite of Vit.D to increase dietary Ca+ absorption and release from bone.
PTH stimulates renal tubular Ca+ reabsorption and PO4- excretion.
PTH stimulates bone release of Ca+. |
|
|
Term
|
Definition
Osteoporosis and Paget's
Bisphosphonate - slows bone turnover by inhibiting osteoclast enzymes |
|
|
Term
|
Definition
Osteoporosis
Bisphosphonate - slows bone turnover by inhibiting osteoclast enzymes |
|
|
Term
|
Definition
Osteoporosis, Paget's, Hypercalcemia
Bisphosphonate - slows bone turnover by inhibiting osteoclast enzymes |
|
|
Term
|
Definition
Osteoporosis
Bisphosphonate - slows bone turnover by inhibiting osteoclast enzymes |
|
|
Term
|
Definition
Osteoporosis
PTH - low dose stimulates osteoBLASTS |
|
|
Term
|
Definition
Osteoporosis
Estrogen therapy - post-menopausal osteoporosis |
|
|
Term
|
Definition
Osteoporosis and hypoparathyroidism
Vitamin D - increases absorption and decreases renal excretion of Ca+ |
|
|
Term
|
Definition
decreases osteoclast activiy - lowers plasma Ca+
Hypercalcemia, Paget's |
|
|
Term
|
Definition
Hypercalcemia
amino substituted bisphosphonate
-in MALIGNANCY hypercal, reduces pain and fractures |
|
|
Term
|
Definition
Multinucleated osteoclasts cause increased bone turnover with abnormal formation.
High risk of fracture and pain. |
|
|
