Term
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Definition
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Term
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Definition
| Inhibit prokaryotic type II topoisomerase. Bactericidal by dsDNA breaks |
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Term
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Definition
| Cipro/Gati/Levo/Moxi/Nor/O-floxacin |
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Term
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Definition
| Gram-negative {Cartilage/tendon damage, peripheral neuropathy, increased intracranial pressure, seizure, hypersensitivity, GI disturbance} [tizanidine w/ ciprofloxacin] Target or efflux resistance |
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Term
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Definition
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Term
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Definition
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Term
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Definition
| Mycobacteria {Thrombocytopenia, hepatotoxicity, fluid discoloration, elevated liver function tests, GI disturbance} [Neisseria meningitidis] Quick rifampin resistance. Rifampin reduces cyclosporine. Avoid clarithromycin and rifabutin |
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Term
| 16s of 30s antibacterials |
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Definition
| Aminoglycosides, Spectinomycin, Tetracyclines, Glycylcyclines |
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Term
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Definition
| Bactericidal due to misread proteins. Synergistic with beta-lactam antibiotics. Resistance: plasmid transferase, inpaired entry, 30s mutation |
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Term
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Definition
| Amika/Gentami/Kanamy/Neomy/Netilmi/Paromomy/Streptomy/Tobramy-cin |
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Term
| Aminoglycoside Information |
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Definition
| Serious Gram-negatives {Ototoxicity, acute renal failure, neuromuscular blockade, repiratory paralysis} [hypersensitivity] |
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Term
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Definition
| Gonorrhea alternative {Injection site pain, nausea, dizziness, insomnia} [Hypersensitivity} 70s forms but translocation is blocked |
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Term
|
Definition
| Chlortetra/Demeclo/Doxy/Metha/Mino/Oxytetra/Tetra-cycline |
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Term
|
Definition
| Actively transported, Resistance: plasmid efflux pumps or enzymatic inactivation |
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Term
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Definition
| C. acnes, H. influenzae, V. cholerae, spirochetes, M. pneumoniae, Chlamydia, rickettsia {Bulging fontanelle, teeth hypoplasia, growth retardation, hepatotoxicity, pseudotumor cerebri, photosensitivity, rash, candidal infection} [Later pregnancy, infancy, child, renal impairment] Take on empty stomach without calcium |
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Term
|
Definition
| Malaria prophylaxis. Okay with renal impairment |
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
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Term
|
Definition
| Skin infection, abdominal infection {GI disturbance} Avoid acitretin causing increased intracranial pressure, similary to tetracyclines |
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Term
| 23s of 50s near peptidyl transferase active center |
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Definition
| Macrolides, Ketolides, Chloramphenicol, Lincosamides, Streptogramins, Oxazolidinones |
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Term
|
Definition
| Azithromycin, Clarithromycin, Erythromycin |
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Term
|
Definition
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|
Term
| Macrolide & Ketolide Information |
|
Definition
| {Acute cholestatic hepatitis, ototoxicity, GI disturbance} [hepatic dysfunction] Inhibit hepatic metabolism, greater oral digoxin absorption. Resistance: 50s mutation, methylases, esterases |
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Term
|
Definition
| {Rare fulminant hepatic necrosis} |
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Term
|
Definition
| C. acnes, Legionella, Treponema pallidum, M. pneumoniae, Chlamydia |
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Term
|
Definition
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Term
|
Definition
| increased H. influenzae and M. catarrhalis |
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Term
|
Definition
| Broad-spectrum esp. anaerobes and rickettsiae {G6PD hemolytic anemia, aplastic anemia, gray baby} Antagonizes penicillins and aminoglycosides, inhibit mitochonria and hepatic function |
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Term
|
Definition
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Term
|
Definition
| Anaerobes {Pseudomembranous colitis, increased liver tests, jaundice, GI disturbance, rash} C. difficile growth |
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Term
|
Definition
| dalfopristin/quinupristin |
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Term
| Dalfopristin/quinupristin |
|
Definition
| VRE, skin infection by staph/strep {GI disturbance, hyperbilirubinemia, arthralgia, myalgia, headache} [SSRIs, Pimozide causing cardiotoxicity] |
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Term
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Definition
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