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Pharm 28
Golan Second Edition
35
Pharmacology
Graduate
03/14/2011

Additional Pharmacology Flashcards

 


 

Cards

Term
GnRH Agonists
Definition
Gonadorelin, Goserelin, Histrelin, Leuprolide, Nafarelin
Term
GnRH Antagonists
Definition
Cetrorelix, Ganirelix
Term
Testosterone to DHT Conversion Inhibitors
Definition
Finasteride
Term
Finasteride MOA
Definition
Inhibit type II 5alpha-reductase
Term
Finasteride
Definition
Benign prostatic hyperplasia, Androgenic alopecia {Male breast neoplasm, breast tenderness, decreased libido, ED, ejaculatory disorder} [Pregnancy, women/children] Improves decreased urine flow. TURP alternative. Effective prostate reduction. Women should not handle
Term
Aromatase Inhibitors
Definition
Anastrozole, Letrozole, Exemestane, Formestane
Term
Competitive/Reversible Aromatase Inhibitors
Definition
Anastrozole, Letrozole
Term
Irreversible/Suicide Aromatase Inhibitors
Definition
Exemestane, Formestane
Term
Anastrozole, Letrozole, Exemestane, Formestane
Definition
Early-stage and metastatic estrogen receptor positive breast cancer {Osteoporotic fracture, thrombophlebitis, hypercholesterolemia, vaginal bleeding, edema, rash, nausea, arthralgia, bone pain, headache, depression dyspnea} [hypersensitivity] May be more effective than estrogen antagonists or SERMS
Term
Selective Estrogen Receptor Modulators (SERMS)
Definition
Tamoxifen, Clomiphene, Raloxifene
Term
Tamoxifen
Definition
Prevention/Palliative for breast cancers, post-lumpectomy {Malignant neoplasm of endometrium, stroke, cataract, pulmonary embolism, hot flashes, abnormal menses, vaginal discharge} [DVT or PE history, not a concern for breast cancer] No more than 5 years due to endometrial cancer risk
Term
Clomiphene
Definition
Female infertility due to anovulation {Thromboembolism, ovarian cysts, ovarian hypertrophy, flushing, vasomotor symptoms, abdominal discomfort} [Pregnancy, thyroid or adrenal dysfunction, liver disease, endometrial carcinoma, ovarian cysts, intracranial lesion]
Term
Clomiphene MOA
Definition
Estrogen receptor antagonist in hypothalamus and anterior pituitary, partial agonist in ovaries. Disinhibitis GnRH release. Increases FH and LSH.
Term
Estrogen Receptor Antagonists
Definition
Fulvestrant
Term
Fulvestrant
Definition
Treatment of ER+ metastatic breast cancer in post-menopausal women when anti-estrogen ineffective. {Nausea, asthenia, pain, vasodilation, headache} [Pregnancy] SERD
Term
Androgen Receptor Antagonists
Definition
Flutamide, Spironolactone
Term
Flutamide
Definition
Metastatic prostate cancer, Benign prostatic hypertrophy {Hepatotoxicity, hematopoietic system disorders, hot flash, diarrhea, nausea, rash} [severe hepatic impairment] Better than DES and leuprolide. Combine with castration.
Term
Spironolactone
Definition
hirsutism, Acne vulgaris, hypertension, edema with HF or cirrhosis, hypokalemia, primary aldosteronism {Hyperkalemia metabolic acidosis, GI hemorrhage, agranulocytosis, SLe, breast cancer?, gynecomastia, dyspepsia, lethargy, abnormal menstruation, impotence, rash} [anuria, hyperkalemia, renal insufficiency] Activity at androgen receptor
Term
Progesterone Receptor Antagonists
Definition
Mifepristone (RU-486), Asoprisnil
Term
Mifepristone (RU-486)
Definition
Abortion through day 49. {Prolonged bleeding time, bacterial infections, sepsis, nausea, vomiting diarrhea, cramps, abnormal vaginal bleeding headache} [Chornic adrenal failure, ectpic pregnancy, blooding disorders, porhyrias, IUD, adnexal mass]
Term
Mifepristone MOA
Definition
Progesterone block causes decay of decidua. Misoprostol coadministration stimulates uterine contractions and nausea. Potentially useful for ectopic ACTH syndrome
Term
Asoprisnil
Definition
Investigational agent for endometriosis and leiomyomata (fibroids)
Term
Estrogens
Definition
Ethinyl estradiol, Mestranol
Term
Progestins
Definition
Norgestrel, Levonorgestrel, Norethindrone, Norethindrone acetate, Ethynodiol, Norgestrimate, Gestodene, Desogestrel, Drospirenone
Term
Estrogen-Progestin Contraception Adversia
Definition
{Arterial venous thromboembolism, PE, stroke, cholecystitis, HTN, hepatic neoplasm, break-through bleeding, breast tenderness, bloating, migraine, weight change} [Breast/endometrial/liver cancer, Pregnancy, smokers over 35, thrombotic disorders, HTN, immobilization, Heart/cerebral artery disease]
Term
Lovonorgestrel
Definition
Emergency contraception (Morning after or Plan B pill)
Term
Norgestrel and Levonorgestrel
Definition
highest androgenic activity
Term
Norethindrone and norethindrone acetate
Definition
Medium androgenic activity
Term
Ethynodiol, norgestimate, gestodene, and desogestrel
Definition
Low androgen receptor cross-reactivity
Term
Drospirenone
Definition
Anti-androgenic activity
Term
Progestin only Contraceptives
Definition
Norgestrel, Norethindrone, Medroxyprogesterone acetate, Etonogestrel
Term
Medroxyprogesterone
Definition
Injectable every 3 months
Term
Etonogestrel
Definition
Silastic implant for 3 years
Term
Hormone Replacement Androgens
Definition
Testosterone enenthate, Testosterone cypionate
Term
Testosterone enanthate/cypionate
Definition
Hypogonadism {Cholestatic jaundice, liver carcinoma, benign prostatic hyperplasia, prostate cancer, acne, gynecomastia, irritation, transfer to female, headache} [Breast/prostate cancer, Pregnancy] Various administration routes. Abused by athletes
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