Term
| Cyclooxygenase Inhibitors |
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Definition
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Term
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Definition
| Coronary syndromes, arthritis, pain. (GI bleed, renal insufficiency, thombocytopenia, hepatitis, angioedema, Reye's syndrome) [children, G6PD deficiency, bleeding disorders] Nonselective, potentiates ototoxic effects, toxicity with urine acidifiers. |
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Term
| Phosphodiesterase Inhibitors |
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Definition
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Term
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Definition
| Prophylaxis against thromboembolic disorders. (Exacerbation of angina, MI, arrhythmia, bronchospasm) weak antiplatelet, often with warfarin, coronary steal phenomenon |
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Term
| ADP receptor Pathway Inhibitors |
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Definition
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Term
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Definition
| Secondary prevention of thrombotic strokes. Stent w/aspirin (Aplastic anemia, neutropenia, TTP) [Bleeding, neutropenia or liver dysfunction] myelotoxicity, loading dose required |
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Term
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Definition
| Secondary prevention of atherosclerotic events w/ MI, stent w/ aspirin. (Atrial fibrillation, HF, erythema multiforme, GI hemorrhage, neurtropenia, renal dysfunction] Less myelotoxic. |
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Term
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Definition
epitifibatide, abciximab, tirofiban.
(Bleeding, intracerebral, thrombocytopenia) [bleeding disorders, HTN] |
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Term
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Definition
| Acute coronary, percutaneous cornary intervention. Don't mix with another in same class. Synthetic peptide. |
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Term
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Definition
| Adjunct to percutaneous coronary intervention, unstable unresponsive angina. chimeric mouse-human monoclonal antibody |
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Term
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Definition
| Acute coronary dyndromes w/ angioplasty. nonpeptide tyrosine analogue |
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Term
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Definition
| Warfarin, Heparin, Fondaparinux, Hirudins, Argatroban, r-APC |
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Term
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Definition
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Term
| Direct Thrombin Inhibitors |
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Definition
| hirudins (lepirudin, desirudin, bivalirudin), argatroban |
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Term
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Definition
| Embolic Prophylaxis (Cholesterol embolization syndrome, necrosis, mehorrhage, hepatitis, hypersensitivity) [pregnancy, hemorrhage, bleeding, anesthesia] Monitor PT and INR, FFP antidote. |
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Term
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Definition
| Anticoagulant, DIC. (Hemorrhage, heparin-induced thrombocytopenia, anaphylactoid reactions) [coagulative concerns, HTN] Higher thrombocytopenic rates. Counteracted by antihistamines, nicotine, tetracyclines etc. Avoid dong quai, garline, ginger etc. |
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Term
| Enoxaparin, Dalteparin, Tinzaparin |
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Definition
| LMW haparines, same as heparin but more edema. Tinzaparin not for percutaneous coronary intervention. |
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Term
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Definition
| DVT, PE. (Typical anticoagulant adversia) [etc] pentasachride for binding antithrombin III. Cleared Renally. |
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Term
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Definition
| Heparin-induced thrombotytopenia, inhibits both free and fibrin-bound thrombin. |
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Term
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Definition
| Leech protein. (HF, GI hemorrhage, bleeding, liver dysfunction, anaphylaxis, hypotension, renal failure) Cleared renally. All derivatives share all traits |
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Term
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Definition
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Term
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Definition
| coronary angiography/angioplasty. thrombin slowly cleaves allowing reactivation. |
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Term
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Definition
| Coronary artery thrombosis, heparin-induced thrombocytopenia (Cardiac arrest, tachycardia, hypotension) Binds only the active site. Liver excretion. |
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Term
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Definition
| Recombinant Activated Protein C: Severe sepsis with organ dysfunction. (Hemorrhage) [Intracranial anything, stroke recently] aPTT but little PT affect |
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Term
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Definition
Streptokinase.
t-PA (Alteplase).
Tenecteplase, Reteplase |
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Term
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Definition
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Term
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Definition
| STEMI, thrombosis, DVT, PE, catheter occlusion. (Typical thrombolytic adversia) [Bleeding etc] Builds immunity. Causes systemic fibrinolysis |
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Term
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Definition
| MI, Stroke, PE, catheter occlusion. (Typical thrombolytic adversia) Binds to newly formed thrombi. |
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Term
| Typical thrombolytic adversia |
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Definition
| (Cardiac arrhythmia, cholesterol embolus syndrome, GI hemorrhage, allergic reaction, intracranial hemorrhage) |
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Term
| Tenecteplase and Reteplase |
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Definition
| MI. (Typical thrombolytic adversia) genetically engineered t-PA variant |
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Term
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Definition
Protamine.
Aprotinim.
Aminocaproic acid, tranexamic acid |
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Term
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Definition
| Aminocaproic acid, Tranexamic acid |
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Term
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Definition
| Heparin overdose (Bradyarrhythmia, hypotension, circulatory collapse, edema) cannot affect fondaparinux |
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Term
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Definition
| Serine-Protease Inhibitor: reduce perioperative bleeding (HF, MI, shock, blooding etc) high doses paradoxical. renal failure risk |
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Term
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Definition
| fibrinolytic disorders, hemorrhage from fibrinolysis. (Bradyarrhythmia, hypotension, myopathy, renal failure) [DIC] Less renal failure than Aprotinin |
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Term
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Definition
| fibrinolytic disorders, hemorrhage from fibrinolysis. (Bradyarrhythmia, hypotension, renal failure) [DIC] Less renal failure than Aprotinin |
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