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Pharm 20 - Drugs used in asthma
pharm of asthma drugs
47
Pharmacology
Graduate
02/09/2011

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Cards

Term
Albuterol - MOA?
Definition
selective B2 agonist
Term
Albuterol - effects?
Definition
Prompt, effective bronchodilation
Term
Albuterol - clinical applications?
Definition
asthma, COPD, DOC for acute asthmatic bronchospasm
Term
Albuterol - Kinetics, tox?
Definition
aerosol inhalation, several hour DOA, available for neb and parenteral, tremor, tachy, OD- arrthymias
Term
Salmeterol - MOA?
Definition
selective B2 agonist
Term
Salmeterol - effects?
Definition
slow onset, primarily preventive, potentiates corticosteriod effects
Term
Salmeterol - clinical applications?
Definition
asthma prophylaxis
Term
Salmeterol - kinetics, tox?
Definition
aerosol inhalation, 12-24 DOA, tox - tremor, tachy, OD - arrythmias
Term
How do metaproterenol and terbutaline differ from the class prototype?
Definition
Similar to albuterol, terbutaline is available as an oral drug
Term
Formoterol is similar to...
Definition
salmeterol
Term
Epinephrine - MOA?
Definition
nonselective a and B agonist
Term
Epinephrine - effects?
Definition
bronchodilation plus all other sympathomimetic effects on CV and other organ systems
Term
Epinephrine - clinical applications?
Definition
anaphylaxis, asthma, others, rarely used for asthma because B2 selective agonists are preferred
Term
Epinephrine - kinetics, tox?
Definition
aerosol, neb or parenteral
Term
Isoproterenol - MOA?
Definition
B1 and B2 agonist
Term
Isoproterenol - effects?
Definition
bronchodilation plus powerful CV effects
Term
Isoproterenol - clinical applications?
Definition
asthma, but B2 selective agents are preferred
Term
Isoproterenol - kinetics, tox?
Definition
aerosol, neb or parenteral
Term
Fluticasone, inhaled - MOA?
Definition
Alters gene expression
Term
Fluticasone, inhaled - effects?
Definition
reduces mediators of inflammation, powerful prophylaxis of exacerbations
Term
Fluticasone, inhaled - clinical applications?
Definition
asthma, adjunct in COPD
Term
Fluticasone, inhaled - kinetics, neb?
Definition
aerosol, duration hours, tox - limited by aerosol application, candidal infection, vocal cord changes
Term
Beclomethasone, budesonide, flunisolide, others - similar to...
Definition
fluticasone
Term
Prednisone - MOA?
Definition
Alters gene expression
Term
Prednisone - effects?
Definition
reduces mediators of inflammation, powerful prophylaxis of exacerbations
Term
Prednisone - clinical applications?
Definition
asthma, adjunct in COPD
Term
Prednisone - kinetics, tox?
Definition
Oral, 12-24 hr DOA, tox - multiple (related to adrenal suppression)
Term
Methylprednisolone is similar to what other drug? How is it administered?
Definition
prednisone, parenteral
Term
Cromolyn and nedocromil - MOA?
Definition
alters function of delayed chloride channels, inhibits inflammatory cell activation
Term
Cromolyn and nedocromil - clinical effects?
Definition
prevents acute bronchospasm
Term
Cromolyn and nedocromil - clinical applications?
Definition
asthma, other routes used for ocular, nasal and GI allergy
Term
Cromolyn and nedocromil - kinetics, tox?
Definition
aerosol, 6-8 hr DOA, tox - cough, not absorbed so other tox is minimal
Term
Theophylline - MOA?
Definition
uncertain, PDE inhibition, adenosine receptor antagonist
Term
Theophylline - effects?
Definition
bronchodilation, cardiac stimulation, increased skeletal muscle strength
Term
Theophylline - clinical applications?
Definition
asthma, COPD
Term
Theophylline - kinetics, tox?
Definition
oral, 8-12 hr DOA but extended release preps often used, tox - multiple (think caffeine)
Term
Montelukast, zafirlukast - MOA?
Definition
block leukotriene D4 receptors
Term
Montelukast, zafirlukast - effects?
Definition
block airway response to exercise and antigen challenge
Term
Montelukast, zafirlukast - clinical applications?
Definition
prophylaxis of asthma, especially in children and in aspirin-induced asthma
Term
Montelukast, zafirlukast - kinetics, tox?
Definition
oral, duration hours, tox is minimal
Term
Omalizumab - MOA?
Definition
humanized IgE antibody reduces circulating IgE
Term
Omalizumab - effects?
Definition
reduces frequency of asthma exacerbations
Term
Omalizumab - clinical applications?
Definition
severe asthma inadequately controlled by other agents
Term
Omalizumab - kinetics, tox?
Definition
parenteral, 2-4d duration, tox - injection site reactions, anaphylaxis extremely rare
Term
Zileuton - MOA?
Definition
inhibits lipoxygenase, reduces synthesis of leukotrienes
Term
What is a muscarinic antagonist used in asthma?
Definition
ipratropium
Term
What is tiotropium?
Definition
a longer acting, somewhat selective antimuscarinic agent, approved for COPD, alternative to longer acting B agonists for asthma but still under investigation
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