Term
| drug used to treat acute lymphoblastic leukemia that blocks DNA and RNA synthesis, and causes oxygen radicals which can damage cardiac tissue when given at high doses. You will carefully monitor to avoid cardiac toxicity. |
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Definition
| Anthracyclines (doxorubicin, daunorubicin, idarubicin) |
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Term
| agent used to treat solid tumors and hematologic malignancies |
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Definition
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Term
| agent used to treat acute leukemia and neuroblastoma |
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Definition
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Term
| agent used to treat acute myeloid leukemia |
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Definition
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Term
| 2 yo boy with Wilms' tumor, one drug used in treatment will inhibit RNA synthesis and can cause bone marrow suppression, platelets and leukocytes will be monitored closely. |
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Definition
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Term
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Definition
| "radiation recall" = skin abnormalities at sites that have previously received radiation. |
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Term
| agent used to treat testicular cancers and Paget disease of the bone |
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Definition
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Term
| agent used to treat hypoxic tumor cells in certain solid malignancies |
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Definition
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Term
| pt with testicular cancer persents with SOB, you suspect pulmonary fibrosis secondary to a treatment med... |
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Definition
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Term
| in what two medication is myelosuppression rare? |
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Definition
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Term
| agent used to treat CML and polycythemia vera |
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Definition
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Term
| pt with breast cancer currently under treatment presents with copious blood and RBCs on UA. You wonder if the sypmtoms are related to her chemotherapeutic regimen |
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Definition
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Term
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Definition
| hemorrhagic cystitis, bone marrow suppression |
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Term
| chemotherapy agents that act to cross-link DNA strands and thereby inhibit DNA synthesis. |
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Definition
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Term
| what drugs are included in the nitrosoureas |
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Definition
| carmustine, lomustine, semustine, streptozocin |
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Term
| agent used to treat brain tumors |
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Definition
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Term
| agent used to treat insulinomas |
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Definition
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Term
| unique characteristic of nitrosoureas |
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Definition
| highly lipid soluble and cross the BBB, thus they are useful in treating CNS malignancies. |
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Term
| Pt with bladder cancer presents with gross sensorinueral hearing loss bilaterally |
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Definition
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Term
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Definition
| nephrotoxicity, ototoxicity |
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Term
| agent used treat genitourinary tumors |
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Definition
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Term
| medication used for RA that inhibits dihydrofolate reductase and will thereby decreas her body's supply of the active form of folic acid |
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Definition
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Term
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Definition
| teratogen, pulmonary toxicity |
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Term
| what is often given with methotrexate to minimize bone marrow suppression |
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Definition
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Term
| medication whose dosage must be reduced when used in combination with allopurinol |
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Definition
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Term
| drug works by inhibiting purine synthesis |
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Definition
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Term
| pt being treated for colon cancer, noticed increased sensitivity of his eyes to light and painful ulcers on his lips and in his mouth. |
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Definition
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Term
| agent used to treat a variety of adenocarcinoma |
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Definition
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Term
| Pt on follow up for AML, cell cycle specific agent that competitively inhibits DNA polymerase and produces pancytopenia. |
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Definition
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Term
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Definition
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Term
| Pt on follow up of small cell carcinoma of the lung. Pt is loosing her hair and is increasingly nauseous. Her med inhibiting DNA topoisomerase II |
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Definition
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Term
| Pt with Hodgkin Lymphoma currently receiving treatment. Pt has an unsteady gait, hyporeflexia, and right foot drop. Platelets, WBC's and RBC's are normal. |
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Definition
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Term
| agent used to treat testicular cancer and lymphoma |
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Definition
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Term
| agent used to treat ALL and lymphomas |
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Definition
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Term
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Definition
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Term
| medication for breast cancer that acts by interfering with the ability of the mitotic spindle to break down |
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Definition
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Term
| what is a unique indication for paclitaxel? |
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Definition
| coat coronary artery stents |
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Term
| Pt was on alendronate, she developed ulcers, you want to switch her to a new medication to treat her osteoperosis that acts as a mixed estrogen agonist and antagonist. |
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Definition
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Term
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Definition
| increased risk of endometrial cancer and thromboembolism, hot flashes. |
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Term
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Definition
| does NOT increase the patient's risk for endometrial cancer, but still increases the risk for thromboembolism |
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Term
| Pt has CML presents with blood counts on the low end of normal and asks how his chemotherapy drug works, you tell him it acts by inhibiting ribonucleotide reductase, an enzyme involved in making deoxyribonucleotides, the bluiding blocks for DNA. |
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Definition
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Term
| What is a unique indication for hydroxyurea? |
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Definition
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Term
| what is the unique indication for pentostatin? |
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Definition
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Term
| chemotherapy agent that targets HER-2/neu receptors within cancer cells. |
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Definition
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Term
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Definition
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Term
| Pt with CML being treated with alpha-interferon and cytarabine with no improvement. You want to try a new first line treatment that acts by inhibiting tyrosine kinaswe on a mutated gene product, bcr-able associated with his disease. |
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Definition
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Term
| cinical use for imatinib (2) |
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Definition
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