Term
| Name the drug that is a positive inotrope and negative chronotrope |
|
Definition
|
|
Term
| How would you test if someone is dig-toxic in an ambulatory setting |
|
Definition
| Take dig level and check pulse; APICAL PREFERRED TO BRACHIAL |
|
|
Term
| Dig toxicity is considered when the plasma concentration is |
|
Definition
|
|
Term
| Clinical Bradycardia is when the pulse is |
|
Definition
|
|
Term
| What is the t1/2 of Digoxin |
|
Definition
|
|
Term
| What Vitamin does Warfarin (Coumadin) antagonize |
|
Definition
|
|
Term
| What foods contain Vitamin K |
|
Definition
| Brussel sprouts, broccoli, spinach, etc |
|
|
Term
| What is the action of Coumadin |
|
Definition
Interferes with hepatic synthesis of vitamin K
dependent clotting factors resulting in an in vivo depletion of clotting factors II (prothrombin),VII, IX & X
|
|
|
Term
| What happens in a coumadin overdose? |
|
Definition
|
|
Term
|
Definition
| fraction of time it takes blood to clot based on standard |
|
|
Term
| What is the most common target INR (range) |
|
Definition
|
|
Term
|
Definition
| Pulmonary embolus and Deep vein thrombosis (Blood clots) |
|
|
Term
| What is the significance if a person’s INR goes from 2 to 4 |
|
Definition
| It takes longer to clot causing bleeding tendencies |
|
|
Term
| How would you treat a warfarin overdose |
|
Definition
|
|
Term
| Which OTC drugs should not be used with Coumadin |
|
Definition
|
|
Term
| Why should a patient on warfarin avoid falls and physical traumatic accidents |
|
Definition
| They have a higher bleeding tendency and their blood is more difficult to clot |
|
|
Term
| Which diuretic conserves Calcium |
|
Definition
|
|
Term
| Which diuretic wastes Calcium |
|
Definition
|
|
Term
| What is the thiazide-type diuretic with the longest half-life |
|
Definition
|
|
Term
| Which diuretic antagonizes aldosterone |
|
Definition
| Aldactone (spironolactone) |
|
|
Term
| What is the medication to treat HTN and also liver cirrhosis |
|
Definition
| Aldactone (spironolactone) |
|
|
Term
|
Definition
| Promotes Na & H2O retention and lower plasma [K] by acting on Rc in the principal cells of DT and CD in kidney nephron. Upregulates ENaC channels increasing apical Na permaebility |
|
|
Term
| What is the difference between Inspra and spironolactone |
|
Definition
| Inspra has less risk of gynecomastia (No cirrhosis tx?) |
|
|
Term
| Which loop diuretic can be given to a sulfa-allergic patient |
|
Definition
| Furosemide (lasix) though this is a weak sulfa drug and Ethacrynic acid (edecrin) which was the first loop diuretic however this has terrible side effects and is rarely used |
|
|
Term
| Name the potassium sparing diuretics |
|
Definition
| Amiloride, Triamterene, Eplenrenone, Spironolactone |
|
|
Term
| Name the potassium wasting diuretics |
|
Definition
| Furosemide, bumetanide, torsemide, ethacrynic acid, HCTZ, indapamide, clorthalidone, metolazone |
|
|
Term
| Name the combination product of diuretics that have both K+ sparing and wasting |
|
Definition
| triamterene/HCTZ & spironolactone/HCTZ |
|
|
Term
| Name the product that can be used to treat HTN in pregnant patients in the ambulatory setting |
|
Definition
| Hydralazine (apresoline) in hospital and methyldopa (aldomet) otherwise |
|
|
Term
| Why is Aldomet on the Beers list |
|
Definition
| It can cause bradycardia and exacebate depression in elderly |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Isosorbide mononitrate which is the most common nitrate taken (2x/day 7 hours apart) |
|
|
Term
|
Definition
| Isosorbide mononitrate taken once a day |
|
|
Term
| Why should Nitro patches be used 12 on and 12 off |
|
Definition
|
|
Term
| Which beta-blocker is most lipophilic |
|
Definition
|
|
Term
| Name an example of a Ca blocker that can be used to treat tachyarrhythmia |
|
Definition
|
|
Term
| What is the name of a nitroglycerin pumpspray |
|
Definition
|
|
Term
| How should K-Dur 20 mEq tablets be taken |
|
Definition
| with food or mixed in water, do not crush, follow with water |
|
|
Term
| Why not just eat a banana each day |
|
Definition
Not enough Vita K
(only 1 mEq/inch of banana)
|
|
|
Term
| Name the non-selective beta blockers |
|
Definition
| Proporanolol, nadolol, pindolol, carvedilol |
|
|
Term
| Name the selective Beta blockers |
|
Definition
| bystolic (B-1 selective), metropolol (B1 selective), atenolol ( B1 selective) |
|
|
Term
| Why would you not order an Rx for Inderal if the person is using albuterol |
|
Definition
| Albuterol is usually given to asthmatics and you would never give a B-blocker let alone a non selective one to an asthmatic as it will cause constriction of the airways |
|
|
Term
|
Definition
|
|
Term
Why must Coreg be taken with food and what are implications for prescribing it
|
|
Definition
To decrease the rate of absorption and reduce incident of orthostasis
Prescribed for CHF & HTN
|
|
|
Term
| What is Toprol-XL. What are the mg strengths of it |
|
Definition
| metropolol) B1 selective b-blocker in low doses that is less lipophilic than propranolol. 50mg, 100mg (brand), 25mg (G), 50, 100, 200mg 1mg/mL |
|
|
Term
| Which beta blocker has ISA |
|
Definition
|
|
Term
| What is ISA and why is it important? |
|
Definition
| sympathomimetic activity; less bradycardia and tiredness because its not a full blocker |
|
|
Term
| What are the ingredients in Aggrenox |
|
Definition
| aspirin and extended-release dipyridamole |
|
|
Term
Which ingredient in Aggrenox is sugar coated, and which is extended release
|
|
Definition
| extended-release dipyridamole |
|
|
Term
| Which drug for HF and/ or HTN is targeted only to African-American patients |
|
Definition
|
|
Term
| What are the 3 categories of CCBs |
|
Definition
| 1.diphenylalkylamines, 2. benzothiazepines, 3. Dihydropyridines |
|
|
Term
| What are the clinical implications for each category of CCBs |
|
Definition
| diphenylalkylamines - Verapamil is the only member of this class that is currently approved in the United States. It is the least selective of any calcium channel blocker, andhas significant effects on both cardiac and vascular smooth-muscle cells. It is used to treat angina, supraventricular tachyarrhythmias, and migraine headache. 2. benzothiazepines - Diltiazem (like verapamil) affects both cardiac and vascular smoothmuscle cells; however, it has a less side effects & less pronounced negative inotropic effect on the heart compared to that of verapamil. 3. Dihydropyridines - This class of CCBs includes the first-generation nifedipine and five secondgeneration agents for treating cardiovascular disease: amlodipine, felodipine, isradipine, nicardipine, and nisoldipine. All DHPs have a much greater affinity for vascular calcium channels than for calcium channels in the heart. They are therefore particularly attractive in treating hypertension, but NOT arrhythmias. |
|
|
Term
| Which two groups of CCBs are used as anti-arrhythmic agents |
|
Definition
| 1.diphenylalkylamines, 2. benzothiazepines |
|
|
Term
| How do the dihydropyridines totally differ from the other calcium channel blockers |
|
Definition
| have a much greater affinity for vascular calcium channels than for calcium channels in the heart. They are therefore particularly attractive in treating hypertension, but NOT arrhythmias. |
|
|
Term
|
Definition
| Controlled Onset VERApamil to be taken at bedtime. Actione begin at night and have Cmax during AM hours |
|
|
Term
|
Definition
|
|
Term
| Why does verapamil cause constipation |
|
Definition
| Blocks Ca in gut in smooth muscles |
|
|
Term
| What’s the effect of taking grapefruit juice and Procardia together |
|
Definition
| dizziness or exaggerated response to DHP as grapefruit juice is a CYP3A4 inhibitor |
|
|
Term
| What is the meaning of the word: proarrhythmia |
|
Definition
| tendency of antiarrhythmic drugs to facilitate emergence of new arrhythmias |
|
|
Term
| What is the name of the CCB and atorvastatin |
|
Definition
|
|
Term
| What is the name of the dihydropyridine CCB and ACE inhibitor |
|
Definition
|
|
Term
|
Definition
| block conversion of AT I > AT II and decreases aldosterone release from adrenal glands |
|
|
Term
| How do ACE-Is compare to ARBs |
|
Definition
| Same effect different MOA. ARBs block at AT I Rc where ACE-I block ACE |
|
|
Term
| Why must ACE-Is not be used to treat HTN in pregnant patients |
|
Definition
| can cause injury or death to fetus |
|
|
Term
| What is ACE-I problem with angioedema |
|
Definition
| can cause swelling of vessels around mouth, tongue and nasal flds creating a red color and could cause laryngeal swelling |
|
|
Term
| What is the role of increased body bradykinin in the adverse effects of ACEIs, such as dry cough and angioedema |
|
Definition
| increased BK can cause a cough. Increase BK is due toACE blkd b/c ACE breaks down BK |
|
|
Term
| Why do ACE-I cause hyperkalemia |
|
Definition
| They are K-sparring; Suppression of angiotensin II leads to a decrease in aldosterone levels. Since aldosterone is responsible for increasing the excretion of potassium, ACE inhibitors ultimately cause retention of potassium |
|
|
Term
| Why are thiazides and loops used along with ACE-I |
|
Definition
| To balance out K loss or gain |
|
|
Term
| What is the ending of the names of the ACE inhibitors |
|
Definition
|
|
Term
| Why is the route of elimination of Monopril an important factor to remember |
|
Definition
| Fosininpril is eliminated 50% in urine and feces so it is an advantage to those renally impaired. |
|
|
Term
| What are the common endings of the names of the ARBs |
|
Definition
|
|
Term
| Can ARBS be used together with ACEIs |
|
Definition
| Yes as an additive effect |
|
|
Term
| What are some advantages of ARBs over ACEIs |
|
Definition
|
|
Term
| What is the mechanism of action of Apresoline |
|
Definition
| arteriolar vasodilator only and decreases afterload. Should be given with b-blocker to reduce reflex tachycardia |
|
|
Term
| What is drug-induced SLE that can occur with high doses of Apresoline (hydralazine) |
|
Definition
| systemic lupus erythematosus which is reversible upon d/c of drug |
|
|
Term
| What happens to the adverse effects when the drug is discontinued upon appearance of this SLE |
|
Definition
|
|
Term
| Explain the value of BiDil, considering the two components (Bi = 2 and dil = dilation) |
|
Definition
| Isosorbide dinitrate/hydralazine is a fixed dose combination drug treatment specifically indicated for African Americans with congestive heart failure. Designed to reduce the pill burden |
|
|
Term
| Catapres: How does it work in controlling blood pressure |
|
Definition
| central a-2 agonist decreasing NE and blocking cholinergic transmission by being an agonist on a-2 |
|
|
Term
| How would you explain the use of Catapres TTS patch to the patient.TTS = Transdermal Therapeutic System |
|
Definition
| there are 2 patches, 1 is the drug and 1 is an overlay, apply x1/week and rotate sites |
|
|
Term
|
Definition
| an increase in blood pressure in response stopping or reducing high blood pressure medication |
|
|
Term
| Where are alpha-1 receptors located |
|
Definition
| radial mm of eye, arterioles, bronchioles, veins, trigone mm of bladder, ureter, uterus, male sex organs, skin, salivary glands |
|
|
Term
| What are the functions of a-1 Rc |
|
Definition
|
|
Term
| Why are a-1 Rc such a good target for drug therapy |
|
Definition
| when you block them, you can dilate bld vessels or relax contractions |
|
|
Term
| What is the indication for Hytrin & Cardura |
|
Definition
| BPH & HTN as adjunct, never use alone |
|
|
Term
|
Definition
| benign prostatic hypertophy |
|
|
Term
| Why should BPH patients not take an OTC cold pill, such as Nyquil, or Benadryl |
|
Definition
| decreases effectiveness of Cardura and hytrin in treating BPH so patient can’t pee |
|
|
Term
| Why should a person with BPH not take an adrenergic agonist (sympathetic stimulant) or anticholinergic |
|
Definition
| decreases effectiveness of Cardura and hytrin in treating BPH so patient can’t pee |
|
|
Term
| What is the role of weight, salt, stress reduction, and exercise in the treatment of HTN |
|
Definition
The first 3 need to be reduced as they contribute and exacerbate it and exercise needs to be increased as it can help lower HTN
|
|
|
Term
| The elderly male patient has HTN and BPH. Explain the compelling indication to use an alpha-1 blocker for him |
|
Definition
| A-1 blocker with vasodilate bld vessels decreasing HBP and relax the trigone muscle in the bladder to assist in urinating with BPH |
|
|
Term
| What is the main indication for Lopid (Gemfibrozil) and Tricor. |
|
Definition
|
|
Term
| How does Questran (Cholestyramine) work |
|
Definition
| Have anion exchange resins that bind (-) charged bile acids and bile salts in the S.I. The resin/bile complex is excreted in feces. This prevents bile acids from returning to the liver by enterohepatic circulation. Lowering bile acid [ ] causes hepatocytes to increase conversion of cholesterol to bile acids, resulting in replenished supply of these compounds. The intracellular [chol] decreases. This activates an increased hepatic uptake of chol-containing LDL particles leading to a fall in plasma LDL |
|
|
Term
| The “statins”: How do they work |
|
Definition
| They inhibit the first committed enymatic (rate-limiting) step of cholesterol synthesis, thereby lowering elevated LDL chol levels resulting in reduction of coronary events |
|
|
Term
|
Definition
| breakdown of muscle fibers resulting in the release of muscle fiber contents (myoglobin) into the bloodstream |
|
|
Term
| What is the effect of grapefruit juice on statin family of medications |
|
Definition
| Will increase its effects by inhibiting the metabolism |
|
|
Term
| What is the advantage of Pravachol over the other statins |
|
Definition
|
|
Term
| What is the mechanism of action of Zetia |
|
Definition
| Inhibits absorption of cholesterol |
|
|
Term
| What is the name of the drug that combines ezetimibe with a statin |
|
Definition
|
|
Term
| Describe Vaughn Williams classification I |
|
Definition
Na channel blockers
i. IA – slow rate of AP, slow conduction, prolong AP, increase ventricular effective refractory period
ii. IB – decrease duration of AP by shortening reploarization
iii. IC – depress rate of rise in AP, cause conduction slowing but have little effect on duration of membrane AP or vent effective refrac period |
|
|
Term
| Describe Vaughn Williams classification II |
|
Definition
| Beta Blockers – diminish phase 4 depolarization, depressing automaticity, prolonging AV conduction and decreasing HR and contractility |
|
|
Term
| Describe Vaughn Williams classification III |
|
Definition
| Amiodarone Sotalol and others – prolong duration of APw/o altering phase 0 of depolarization or RMP. Prolong effective refrac period |
|
|
Term
| Describe Vaughn Williams classification IV |
|
Definition
| Ca channel blockers – decrease rate of phase 4 spontaneous depolarization and slow conduction in tissues not dependent on Ca currents (AV node) |
|
|
Term
| Which channels are blocked by Class I antiarrhythmic drugs |
|
Definition
|
|
Term
| Which channels are blocked by Class II antiarrhythmic drugs |
|
Definition
|
|
Term
| Which channels are blocked by Class III antiarrhythmic drugs |
|
Definition
|
|
Term
| Which channels are blocked by Class IV antiarrhythmic drugs |
|
Definition
|
|
Term
| What’s the product that has Class III antiarrhythmic effects as well as non-selective beta-blockade |
|
Definition
|
|
Term
| What is the t1/2 of amiodarone |
|
Definition
|
|
Term
| If a patient takes one tablet of amiodarone daily, how many months would it take to get to steady-state |
|
Definition
|
|
Term
| What is the difference between Betapace and Betapace AF |
|
Definition
| Betapace is a racemic mix of d and l isomers and the l isomer is a non selective bete blocker. Betapace AF is for A-flutter and a-fib |
|
|
Term
| Why shouldn’t Betapace be given to a person with emphysema or asthma |
|
Definition
| because it is a non selective beta blocker and will constrict the airways |
|
|
Term
| What is a normal plasma concentration for K+ |
|
Definition
|
|
Term
| Which drugs should be tapered before stopping? |
|
Definition
| SSRIs, antipsychotic drugs, B-blockers, Clonidine, any medication that effects the CNS |
|
|
Term
| What are schedule II controlled substances? |
|
Definition
High abuse potential with severe psychic or physical dependence.
i.e. opium, morphine, methadone, cocaine, oxycodone, amphetamines, methylphenidate |
|
|
Term
| What are schedule III controlled substances? |
|
Definition
Have an abuse potential less than scehdule II.
i.e. Tylnols #3, vicodin, anabolic steroids |
|
|
Term
| What are schedule IV controlled substances? |
|
Definition
Less abuce potential than schedule III.
i.e. Phenobabital, benzodiazepines, lunesta, ambien |
|
|
Term
| What are ceiling diuretics |
|
Definition
| They have a limit to how far you can push the dosage |
|
|
Term
| What is the best drug class to treat HTN AND HIgh Risk Angina |
|
Definition
|
|
Term
| What is the best drug class to treat DB & HTN? |
|
Definition
|
|
Term
| What is the best drug class to treat HTN & recurrent stroke? |
|
Definition
|
|
Term
| What is the best drug class to treat HTN & HF? |
|
Definition
|
|
Term
| What drug class is best for treating HTN & chronic renal disease |
|
Definition
|
|
Term
| What compelling reason would you have to not use diuretics as a first-line against HTN therapy |
|
Definition
DB or chronic renal disease - ACE-I or ARB
Elderly men w/ BPH - a-1 blockers
High Risk angina - B-blockers or CCBs
Previous MI - B-blockers or ACE-I |
|
|
Term
| Why are thiazides useful for elderly HTN pts w/ osteoporosis |
|
Definition
| They increase systemic Ca |
|
|
Term
| What are the adverse effecs of Thiazide diuretics |
|
Definition
HypOkalemia
HypERuricemia
HypERglycemia
HypOmagnesemia |
|
|
Term
|
Definition
Decreases Na, K, Mg; Increases Ca
Diuretic used for Edema, CHF, HTN |
|
|
Term
| Name thiazide-like diuretics |
|
Definition
Indapamide, Clorthalidone (Which is longer lasting - 24 hrs), Metolazone (works near bowmans capsul)
All have are ceiling diuretics and should be added as last resort |
|
|
Term
| Which b-blocker has peripheral vasoconstriction causing white clammy hands |
|
Definition
|
|
Term
| Why is propranolol dangerous to DB pts? |
|
Definition
| It masks hypOglycemia symptoms |
|
|
Term
| Which b-blocker is least likely to cause groginess and depression and why |
|
Definition
| Atenolol becaue it is the most water soluble (Not lipholic) |
|
|
Term
| What patient type are ACE-I most effective on |
|
Definition
| young, white HTN patients |
|
|
Term
| What are adverse effects of ACE-I |
|
Definition
| dry cough, rash, altered taste, hypERkalemia, angioedema, toxic to fetus |
|
|
Term
| When are ACE-I contraindicated |
|
Definition
| Bilateral renal artery stenosis |
|
|
Term
| How do ACE-I and ARBs effect DB pts |
|
Definition
|
|
Term
| If a low dose ACE-I is not working, what is your next choice? |
|
Definition
|
|
Term
| Which class of CCB is the least effective |
|
Definition
| Diphenylalkyamines (Verapimil) |
|
|
Term
| What suffix is associated with CCB DHPs |
|
Definition
|
|
Term
| What would you counsel pts taking CCB DHP against? |
|
Definition
|
|
Term
| What are adverse effects of a-1 blockers |
|
Definition
| reflex tachycardia and 1st does syncope |
|
|
Term
| How would you counsel a pt taking clonidine? |
|
Definition
| Chew sugarless gum, drink fluids (as it causes dry mouth), metamucil, fiber and prunes (as it causes constipation) |
|
|
Term
| What is the most famous B.A.S. |
|
Definition
|
|
Term
| What is the implication for Phenytoine |
|
Definition
| It is a class IB antiarrythmic drug also used to treat epilepsy. It is used to counteract digoxin toxicity when pt is also experiencing arrythmias |
|
|
Term
| Which drug antiarrhythmic drug reselmbles strx of T4 |
|
Definition
|
|
Term
|
Definition
*Potent Diuretics
MOA: Inhibit Na+/K+/2Cl- co-transport in the ascending loop of Henle
Decreases Na+, K+, Mg++, Ca++
Furosemide, Bumetanide, Torsemide, Ethacrynic acid
Indications: Edema, CHF, HTN |
|
|
Term
| Thiazide and Thiazide-type diuretics |
|
Definition
K wasting
Indications: Edema, CHF, HTN
MOA: Inhibit reabsorption of NaCl in early DCT
Decrease Na, K, Mg Increase Ca
Ideal for women w/ Osteoporosis & HTN
These are also Vasodilators
HCTZ, Indapamide, Chlorthalidone, Metolazone |
|
|
Term
|
Definition
MOA:Inhibit Aldosterone reabsorption of Na & secretion of K @ CD
Indications: Edema, HTN, CHF
Spironolactone, Eplerenone
MOA: Na channel blockers @ CD
Triamterene, Amiloride |
|
|
Term
|
Definition
Class II Antiarrythmic
*DO not abruptly d/c; taper down over weeks
Not good for diabetics
propranolol, nadolol, pindolol, bystolic (B1), Metropolol (B1), atenolol (B1), Carvedilol |
|
|
Term
|
Definition
CCB DHP for HTN or Angin
Potent peripheral vasodilator
Do not use grapefuit juice |
|
|
Term
Lotrel
(Amlodipine/benaepril) |
|
Definition
Combo CCB DHP & ACE-I
BP control via 2 different MOAs |
|
|
Term
Verapamil
(Calan, Isoptin, Verelan, Covera) |
|
Definition
CCB non-DHP
Use Reg tabs for HTN, vasospastic unstable & chronic stable angina, Atrial arrhythmias
Use SR tabs for HTN
Do not take w/ digoxin (may increase dig tox)
Take SR tabs with food, may cause constipation |
|
|
Term
Enalapril
(Vasotec, enalaprilat) |
|
Definition
ACE-I
K sparring diuretic used for HTN
**DO NOT give in 2 or 3 trimesters (Use methyldopa or apresoline instead)
PRODRUG
Dosed QD-BID
Injection or tabs
SE: cough, angioedema
Useful in DB patients as it is nephro protective
Enhances vasodilation via BK |
|
|
Term
|
Definition
ACE-I
K sparring diuretic for HTN
**DO NOT give in 2 or 3 trimesters (Use methyldopa or apresoline instead)
For pts who can not swallow (take with apple sauce)
SE: cough, angioedema
Enhances vasodilation via BK
Useful in DB pts as it is nephro protective |
|
|
Term
|
Definition
ARB used for HTN
DO NOT give during 2 or 3 trimester (Use methyldopa or apresoline instead)
less cough due to decreased BK and can be used an additive to ACE-I
This was the first to go generic.
Useful in DB as it is nephroprotective |
|
|
Term
|
Definition
ARB for HTN
DO NOT give during 2 or 3 trimester (Use methyldopa or apresoline instead)
less cough due to decreased BK and can be used an additive to ACE-I
Useful in DB as it is nephroprotective |
|
|
Term
|
Definition
Anti-hypertensive
MOA: (similar to methyldopa) central a-2 agonist which decreases NE and cholinergic a-2 agonist which blocks cholinergic transmission
Dosed by patches or tabs |
|
|
Term
|
Definition
Anti-hypertensive
Arteriolar vasodilator - only works in arteries and decreases afterload
Should be given with b-blocker to decrease reflex tachycardia
Can be used for pregnants pts in hospital
SE: SLE |
|
|
Term
Fenofibrate
(Tricor, Antara, Lofibra) |
|
Definition
Lipid lowering agent
Caution against combo w/ statins as it can cause rhabdomyolysis |
|
|
Term
|
Definition
Lipid lowering agent
Take HS after low fat snack. E.R. minimizes flushing |
|
|
Term
|
Definition
Lipid lowering agent
Taken once daily and has a very small efect on reduction of LDL
MOA: inhibits absorption of chol |
|
|
Term
Ezetimibe/simvastatin
(Vytorin) |
|
Definition
| Lipid lowering agent as adjunctive therapy |
|
|
Term
|
Definition
Class IC antiarrythmic drug (potent)
MOA: blocks Na channels
Dose every 12 hours as scheduled or can produce tachycardia
|
|
|
Term
Amiodarone
(cordarone, pacerone) |
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Definition
Anti-arrhythmic drug which has characteristics of all 4 Vaughn classes (mostly class III, K blockers)
Used for life threatening Vent arrhythmias and A-fib
T1/2 of 50 days. Steady State @ 8 mos
Similar Strx to T4
Do not take with digoxin, warfarin, grapefruit juice
SE: Smurfs syndrome
POtential for fatal toxicity |
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Term
Bidil
(ISDN & hydralazine) |
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Definition
Combo anti-hypertensive & nitrate)
Dose 1 tab TID
Used as HF adjunct in African Americans |
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Term
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Definition
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Term
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Definition
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Term
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Definition
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Term
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Definition
HMG-CoA reductase Inhibitor
Lipid lowering agent |
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Term
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Definition
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