Term
|
Definition
| Inhibition of reuptake transporters for norepinephrine or serotonin |
|
|
Term
|
Definition
| Increase vesicular stores of both NE ad 5-HT, increase in activation of pre- and postsynaptic receptors, and desensitization or down-regulation of transmitter synthesis from an AA, receptor numbers, or postreceptor mechanisms |
|
|
Term
| Metabolism MAO-A is responsible for |
|
Definition
|
|
Term
| Metabolism MAO-B is responsible for |
|
Definition
|
|
Term
| Irreversible block of MAO causes |
|
Definition
| Tyramine accumulation and loss of first-pass metabolism, causing hypotension |
|
|
Term
|
Definition
| Reversal of action of reserpine by iproniazid |
|
|
Term
| Non-reversible non-selective MAOI |
|
Definition
|
|
Term
| Reversible MAOI (30 days) |
|
Definition
| Tranylcypromine (Parnate) |
|
|
Term
| Elevates levels of GABA to tx anxiety |
|
Definition
|
|
Term
|
Definition
| Enhance blood pressure-elevating action of food amines such as tyramine = cheese rxn, hepatic necrosis |
|
|
Term
| Increases cerebral catechol & 5-HT in synaptic clefts via inhibition of reuptake into storage sites |
|
Definition
| trycyclic antidepressants |
|
|
Term
| Increases cerebral catechol & 5-HT in synaptic clefts via inhibition of breakdown |
|
Definition
|
|
Term
|
Definition
| Tricyclic (reuptake inhibitor) |
|
|
Term
|
Definition
| Tricyclics (reuptake inhibitor of serotonin & NE) |
|
|
Term
| Gold std antidepressant with high rate of manic & hypomanic rxns in bipolar dz |
|
Definition
|
|
Term
| Tricyclic that inhibits reuptake of serotonin & NE |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Tricyclic for obsessive-compulsive disorder |
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
|
Definition
|
|
Term
| Affects Dopamine Reuptake, can cause seizures so use at low dose |
|
Definition
| Bupropion (Welbutrin for dep, Zyban for smoking) |
|
|
Term
|
Definition
| nefazodone, venlafaxine, duloxetine, mirtazapine |
|
|
Term
| Less sedating than trazodone, fewer sexual effects than SSRIs, but potent inhibitor of CYP3A4 |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Potent inhibitor of serotonin transport & weaker inhibitor of NE transport, behaves as SSRI at lower doses; at high doses > 225 mg/d increase hr, bp dt NE transporter inhibition |
|
Definition
|
|
Term
| Potent antihistaminic w/ greater sedating effects than 2nd or 3rd gen; causes wt gain |
|
Definition
|
|
Term
| Combines 5-HT2 receptor and -adrenoceptor antagonism; sedative; alt for SSRIs which have sexual adverse effect |
|
Definition
|
|
Term
| High ratios of SERT vs. NET inhibition of 300-7000 |
|
Definition
| Serotonin selective uptake inhibitors |
|
|
Term
| Serotonin selective uptake inhibitors |
|
Definition
| fluoxetine (Prozac), paroxetine (Paxil), sertraline (Zoloft) |
|
|
Term
| Shorter half-lives and different potencies as inhibitors of P450 isoenyzmes |
|
Definition
| Paroxetine (Paxil) and sertraline |
|
|
Term
|
Definition
| Racemic citalopram (Lexapro) & (S)-citralopram (escitalopram) |
|
|
Term
| Less toxic than tricyclic & heterocyclic antidep |
|
Definition
|
|
Term
| 5HT2 & Cat Reup Inhibitor |
|
Definition
|
|
Term
| Potently inhibits neuronal serotonin & NE reuptake |
|
Definition
|
|
Term
|
Definition
| Mirtazapine, escitalopram, venlafaxine, and sertraline |
|
|
Term
|
Definition
| Escitalopram, sertraline, citalopram, buproprion |
|
|
Term
| Least efficacious anti-dep |
|
Definition
| reboxetine, fluvoxamine, paroxetine, duloxetine |
|
|
Term
|
Definition
| Amitriptyline (Elavil), Amoxapine, Clomipramine (Anafranil), Desipramine (Norpramin), Imipramine (Tofranil) |
|
|
Term
|
Definition
| Bupropion (Wellbutrin), Duloxetine (Cymbalta, Mirtazapine (Remeron), Nefazodone (Serzone), Trazodone (Desyrel), Venlafaxine (Effexor) |
|
|
Term
| Selective Serotonin Reuptake Inhibitors |
|
Definition
| Citalopram (Celexa), Escitalopram (Lexapro), Fluoxetine (Prozac), Fluvaxamine, Paroxetine (Paxil), Sertraline (Zoloft) |
|
|
Term
|
Definition
|
|
Term
|
Definition
| Phenelzine (Nardil), Tranylcypromine (Parnate) |
|
|
Term
| Serotonin not inhibited by endproducts so can give |
|
Definition
|
|
Term
|
Definition
|
|
Term
| 360 SE Transporter affinity |
|
Definition
|
|
Term
| 800 SE Transporter affinity |
|
Definition
|
|
Term
| Inhibit Serotonin & NE reuptake |
|
Definition
|
|
Term
|
Definition
|
|
Term
| Not more effective but less S/E |
|
Definition
|
|
