Term
| Clonidine, methyldopa - MOA? |
|
Definition
| centrally acting sympathoplegic, activate a2 adrenoreceptors |
|
|
Term
| Clonidine, methyldopa - effects? |
|
Definition
| Reduce central sympathetic outflow, reduce norepi release from noradrenergic nerve endings |
|
|
Term
| Clonidine, methyldopa - clinical applications? |
|
Definition
| hypertension, clonidine also used in withdrawal from abused drugs |
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Term
| Clonidine, methyldopa - kinetics, tox? |
|
Definition
| oral, clonidine also patch, tox- sedation, methyldopa- hemolytic anemia |
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|
Term
|
Definition
| Blocks vesicular amine transporter in noradrenergic nerves and depletes transmitter stores |
|
|
Term
|
Definition
| Reduce all sympathetic effects, especially CV, reduces BP |
|
|
Term
| Reserpine - clinical applications? |
|
Definition
|
|
Term
| Reserpine - kinetics, tox? |
|
Definition
| oral, long duration (days), tox - psychiatric depression, GI disturbances |
|
|
Term
|
Definition
| Interferes with amine release and replaces norepi in vesicles |
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|
Term
|
Definition
|
|
Term
| Guanethidine - kinetics, tox? |
|
Definition
| oral, long duration, severe orthostatic hypotension, sexual dysfunction |
|
|
Term
| Prazosin, terazosin, doxazosin - MOA? |
|
Definition
| selectively block a1 adrenoreceptors |
|
|
Term
| Prazosin, terazosin, doxazosin - effects? |
|
Definition
| Prevent sympathetic vasoconstriction, reduce prostatic smooth muscle tone |
|
|
Term
| Prazosin, terazosin, doxazosin - clinical applications? |
|
Definition
|
|
Term
| Prazosin, terazosin, doxazosin - kinetics, tox? |
|
Definition
| oral, orthostatic hypertension |
|
|
Term
|
Definition
| causes nitric oxide release |
|
|
Term
|
Definition
| vasodilation, reduce vascular resistance, arterioles more sensitive than veins, reflex tachy |
|
|
Term
| Hydralazine - clinical applications? |
|
Definition
|
|
Term
| Hydralazine - kinetics, tox? |
|
Definition
| oral, angina, tachy, lupus-like syndrome |
|
|
Term
|
Definition
| Metabolite opens K channels in vascular smooth muscle |
|
|
Term
|
Definition
| vasodilation, arterioles more sensitive than veins |
|
|
Term
| Minoxidil - clinical applications? |
|
Definition
|
|
Term
| Minoxidil - kinetics, tox? |
|
Definition
| oral, angina, tachy, hypertrichosis (hirsutism) |
|
|
Term
| Nitroprusside, fenoldopam, diazoxide - what are the MOAs? |
|
Definition
| release NO, activates D1 receps, opens K channels |
|
|
Term
| Nitroprusside, fenoldopam, diazoxide - effect? |
|
Definition
|
|
Term
| Nitroprusside, fenoldopam, diazoxide - clinical applications? |
|
Definition
|
|
Term
| Nitroprusside, fenoldopam, diazoxide - kinetics, tox? |
|
Definition
| parenteral, excessive hypotension, shock |
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