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Pharm 1
Intro Lecture
11
Accounting
Pre-School
04/18/2009

Additional Accounting Flashcards

 


 

Cards

Term
Concentration Dependent Killing
Definition
Exhibits the Post Antibiotic Effect: growth is suppressed even when the [drug] drops below the MIC Only for cidal drugs Simplified dosing regimens. Fluoroquinolones, aminoglycosides.
Term
Time dependent Killing
Definition
Much more common Plasma concentrations must be maintained above the MBC at all times. Only for cidal drugs. B-lactams, vancomycin, isoniazid, pyrazinamide, rifampin
Term
Acquired drug resistance
Definition
arises spontaneously because of mutation prior to drug exposure; drug exposure only provides selective pressure
Term
Example of a drug target that is unique to pathologic cells and not present in host cells
Definition
cell wall in bacteria
Term
example of drug target that is similar but not identical in pathologic cells and host cells
Definition
RNA polymerase or ribosomes in bacteria
Term
example of a drug target that is shared by pathologic and host cells but differs in importance
Definition
cell cycle components in cancer
Term
when is it important to use bactericidal drugs?
Definition
AIDS, chemo, inherited immunodeficiency
Term
why are aminopenicillins able to kill gram- bacteria but penicillins do not?
Definition
penicillins bind PBP which is exposed in gram+ bacteria but inaccessible in gram-; by adding an amino group, the drug is made more polar and therefore can travers porins to affect gram- PBP (amoxicillin, ampicillin)
Term
name 3 examples of drug resistance due to chromosomal mutation:
Definition
MRSA, PRSP, drug-resistant M. tuberculosis
Term
Situations in which empirical antibiotic therapy is used:
Definition
-severe infection
-public health issue (STD)
Term
prophylactic use of antimicrobial drugs is most likely to be effective if it is used to:
Definition
prevent infection by a single organism; (prophylactic therapy should be limited in duration, employ therapeutic drug levels, be used only where efficacy has been documented)
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