Term
|
Definition
NSAID prescription for treating gout
causes CNS side effects
Reversible cox1/2
prolongs gestation
NOT for juvenile RA
closes fetal ductus arteriosis |
|
|
Term
|
Definition
NSAID IM injection for acute gout/anxiety
reversibly inhibit cox1/2 |
|
|
Term
|
Definition
antiinflammatory specific for gout
prevents tubulin polymerization
EXTREME GI upset
removed from market except colcrys |
|
|
Term
|
Definition
inhibits xanthaine oxidase
reduces uric acid formation
*early increased gout (expose crystals)
hard on liver
^ half life of probenecid |
|
|
Term
|
Definition
new xanthine oxidase inhibitor
less GI upset/allergy |
|
|
Term
|
Definition
A uricosuric agent (gout) that inhibits the anion exchange transporter. Increases uric acid excretion.
May cause kidney crystals
Not effective in acute attacks |
|
|
Term
| Rasburicase and Pegloticase |
|
Definition
| Gout: Recombinant urate-oxidase/uricase enzymes which convert uric acid to allantoin. |
|
|
Term
|
Definition
inhibits prostaglandin synth in CNS but not periphery.
Mild inhibitor of COX1/2
para amino phenol derivative No antiinflammatory activity No GI irritation anti-diuretic LIVER TOXICITY |
|
|
Term
|
Definition
selective COX-2 inhibitor (celebrex)
not for patients with SULFONAMIDE allergy, aspirin triad or asthma |
|
|
Term
| Lidocaine (local anesthetics) |
|
Definition
| block sodium channels in nerve endings |
|
|
Term
|
Definition
dopamine precursor
parkinsons |
|
|
Term
|
Definition
inhibit metabolism of dopamine by MAO-B
parkinsons |
|
|
Term
|
Definition
inhibits metabolism of dopamine by COMT
parkinsons
may minimize on/off phenomenon |
|
|
Term
|
Definition
stimulates post-synaptic dopamine receptors ergot derivative parkinsons
may affect on/off phenomenon
may help with on/off phenomenon |
|
|
Term
|
Definition
Non-ergot dopaminergic agonists
parkinsons
restless leg syndrome
may minimize on/off phenomenon |
|
|
Term
|
Definition
stimulates release of dopamine
parkinsons
first used as antiviral |
|
|
Term
| Benztropine, triheriphenidyl, diphenhydramine |
|
Definition
centrally acting antimuscarinics
Parkinsons
CNS activity
remember Ach/DA balance |
|
|
Term
|
Definition
antidepressant without parkinsonism side effects
manage side effects of L-Dopa |
|
|
Term
|
Definition
inhibits DOPA decarboxylase in periphery but not CNS
Parkinsons |
|
|
Term
|
Definition
MAO-B inhibitor
supplement to L-DOPA
Parkinsons |
|
|
Term
| Acetyl Salicylic Acid (aspirin) |
|
Definition
Salicyclic acid derivative
COX-1/2 inhibitor
IRREVERSIBLY acetylate cox 1- blocks arachadonic acid->prostaglandins
prevents platelet aggregation by thromboxane A2 irreversibly 4-7 days
highly bound to albumin
excreted rapidly when alkaline urine
dissolution is rate-limiting
long-term large doses cause tinnitus
pulmonary edema
polyps in asthma patients |
|
|
Term
|
Definition
Salicyclic acid derivative
reversible COX-1/2 inhibitor
Long half life, similar to aspirin |
|
|
Term
|
Definition
Acetic Acid derivative
reversible COX-1/2 inhibitor MORE COX 2
less severe GI than indomethacin |
|
|
Term
|
Definition
Acetic Acid derivative
reversible COX-1/2 inhibitor
CNS dizziness |
|
|
Term
|
Definition
Acetic Acid derivative
Reversable COX-1/2 inhibitor
Anaphylactoid reactions
Juvenile rheumatoid arthritis |
|
|
Term
|
Definition
Propionic Acid derivative
reversible COX-1/2 inhibitor
Juvanile RA
do not use when nursing |
|
|
Term
|
Definition
Propionic Acid derivative
reversible COX-1/2 inhibitor
GI in 30% patients |
|
|
Term
|
Definition
Propionic Acid derivative
reversible COX-1/2 inhibitor
once daily |
|
|
Term
|
Definition
Enolic Acid Derivative
Oxicams
reversible COX-1/2 inhibitor |
|
|
Term
|
Definition
Enolic Acid Derivative
Oxicams
reversible COX-1/2 inhibitor |
|
|
Term
|
Definition
Non acidic compound
COX-1/2 inhibitor MORE cox2
activated by liver |
|
|
Term
|
Definition
short acting
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
intermediate acting
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
short-med acting
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
intermediate acting
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
long acting
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
mineralocorticoid agonist
corticosteroid for stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior |
|
|
Term
|
Definition
| glucocorticoid synth inhibitor |
|
|
Term
|
Definition
glucocorticoid synth inhibitor
antifungal |
|
|
Term
|
Definition
| Mineralocorticoid antagonist |
|
|
Term
|
Definition
synthetic ACTH (corticotropin)
corticosteroid |
|
|
Term
|
Definition
reversible cox 1/2
less GI toxicity than aspirin or indomethacin
ocular disturbances
avoid during pregnancy
close fetal ductus arteriosis |
|
|
Term
|
Definition
DA receptor agonist
ergot derivative
may decrease on/off phenomenon |
|
|
Term
|
Definition
monotherapy
tonic-clonic and partial
prolongs Na channels
drugs (warfarin) metabolized by CYP2C9 affected
gingival hyperplasia
SJS |
|
|
Term
|
Definition
monotherapy tonic-clonic and partial
prolongs Na channels
induces own metabolism
Acute side effects: stupor, coma, hyperirritability convulsions
Chronic side effects: drowsiness, vertigo, ataxia, blurred vision |
|
|
Term
|
Definition
Monotherapy/adjunctive
partial seizures
prolongs Na channels
Prodrug
does not autoinduce
Dizziness, nasuea, somnolence, ataxia |
|
|
Term
|
Definition
monotherapy
absence seizures
inhibits T-type Ca channels
not plasma bound-- few interactions
nausea, vomiting, anorexia, drowsiness, letahrgy, euphoria, SJS, aplastic anemia |
|
|
Term
|
Definition
monotherapy
all types of seizures
T-type Ca channels, prolongs Na channels, increase GABA synth
GI nausea, anorexia, sedation, ataxia, tremor, increase hepatic enzymes
displaces phenytoin from plasma proteins |
|
|
Term
|
Definition
only for adjunctive treatment of absence
inhibit GABA receptor
drowsiness, lethargy, aggression, hyperactivity, irritability
withdrawl causes status epilepticus |
|
|
Term
|
Definition
suppress neuronal activity
treat neuropathic pain
not metabolized
fatigue, ataxia |
|
|
Term
|
Definition
monotherapy and adjunctive
partial and tonic/clonic
prolong Na channels
dizziness, ataxia, blurred vision, nausea, rash and SJS when added to other AEDs |
|
|
Term
|
Definition
Adjnctive for partial in adults
very save-- no interactions
somnolence, dizziness, asthenia |
|
|
