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Definition
| an enzyme produced in the kidneys that promotes the conversion of plasminogen to plasmin and can be used to dissolve blood clots. (Thrombolytic) |
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Definition
| (Calcium channel blocker) Inhibits calcium ion entry across cardiac, vascular smooth-muscle cell membranes, dilating coronary arteries, peripheral arteries, arterioles. Decreases heart rate, myocardial contractility; slows SA, AV conduction. Decreases total peripheral vascular resistance by vasodilation. (Antihypertensive, antianginal, antiarrhythmic, hypertrophic cardiomyopathy therapy adjunct) |
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Definition
| Blocks beta1-, beta2-adrenergic receptors. Decreases oxygen requirements. Slows AV conduction, increases refractory period in AV node. Large doses increase airway resistance. Slows heart rate; decreases cardiac output, B/P, myocardial ischemia severity. Exhibits antiarrhythmic activity. (Antihypertensive, antianginal, antiarrhythmic, antimigraine) |
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Definition
| Increases electrical stimulation threshold of ventricles, His-Purkinje system. Decreases myocardial excitability, conduction velocity; depresses myocardial contractility. Exerts direct cardiac effects. Suppresses arrhythmias.(Antiarrhythmic) |
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Definition
| Dilates coronary arteries, improves collateral blood flow to ischemic areas within myocardium. IV form produces peripheral vasodilation. Decreases myocardial oxygen demand. Reduces left ventricular preload, afterload.(Antianginal, antihypertensive, coronary vasodilator) |
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Definition
| Inhibits calcium ion movement across cell membranes, depressing contraction of cardiac, vascular smooth muscle. Increases heart rate, cardiac output. Decreases systemic vascular resistance, B/P.(Calcium channel blocker; Antianginal, antihypertensive) |
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Definition
| Selectively blocks beta1-adrenergic receptors; high dosages may block beta2-adrenergic receptors. Decreases oxygen requirements. Large doses increase airway resistance. Slows heart rate, decreases cardiac output, reduces B/P. Decreases myocardial ischemia severity (Beta1-adrenergic blocker; Anti-anginal, antihypertensive, MI adjunct) |
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Term
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Definition
| Suppresses renin-angiotensin-aldosterone system (prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor; may inhibit angiotensin II at local vascular, renal sites). Decreases plasma angiotensin II, increases plasma renin activity, decreases aldosterone secretion. Reduces peripheral arterial resistance, B/P (afterload), pulmonary capillary wedge pressure (preload), pulmonary vascular resistance. In those with heart failure, decreases heart size, increases cardiac output, exercise tolerance time.(ACE inhibitor; Antihypertensive) |
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Definition
| Anesthetic: Inhibits conduction of nerve impulses. Causes temporary loss of feeling/sensation. Antiarrhythmic: Decreases depolarization, automaticity, excitability of ventricle during diastole by direct action. Inhibits ventricular arrhythmias (Amide anesthetic; Antiarrhythmic, anesthetic) |
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Definition
| Diuretic: Blocks reabsorption of water, sodium, potassium at cortical diluting segment of distal tubule. Antihypertensive: Reduces plasma, extracellular fluid volume, peripheral vascular resistance by direct effect on blood vessels. Promotes diuresis; reduces B/P (Thiazide diuretic, antihypertensive) |
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Definition
| Enhances excretion of sodium, chloride, potassium by direct action at ascending limb of loop of Henle. Produces diuresis, lowers B/P (Loop diuretic; Diuretic) |
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Term
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Definition
| Blocks beta1-adrenergic receptors in cardiac tissue. Slows sinus node heart rate, decreasing cardiac output, B/P. Decreases myocardial oxygen demand(Beta1-adrenergic blocker; Antihypertensive, antianginal, antiarrhythmic) |
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Definition
| Enhances excretion of sodium, chloride, and, to lesser degree, potassium, by direct action at ascending limb of loop of Henle and in proximal tubule. Produces diuresis.(Loop diuretic; Diuretic) |
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Term
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Definition
| Suppresses renin-angiotensin-aldosterone system (prevents conversion of angiotensin I to angiotensin II, a potent vasoconstrictor; may inhibit angiotensin II at local vascular and renal sites). Decreases plasma angiotensin II, increases plasma renin activity, decreases aldosterone secretion. Reduces peripheral arterial resistance, pulmonary capillary wedge pressure; improves cardiac output, exercise tolerance (Angiotensin-converting enzyme (ACE) inhibitor; Antihypertensive, vasodilator) |
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Definition
| Chlorothiazide affects the distal renal tubular mechanism of electrolyte reabsorption (thiazide diuretic; hypertensive) |
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Term
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Definition
| Inhibits calcium movement across cardiac, vascular smooth-muscle cell membranes (causes dilation of coronary arteries, peripheral arteries, arterioles). Decreases heart rate, myocardial contractility; slows SA, AV conduction; decreases total peripheral vascular resistance by vasodilation (Calcium channel blocker; Antianginal, antihypertensive, antiarrhythmic) |
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