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| more than one peripheral nerve |
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| motor end-plate or muscle |
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| peripheral nerve or dermatome distribution |
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| peripheral nerve or myotome |
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| abnormal sensations such as tingling, burning, pricking, or tickling |
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| primary destruction of the myelin or myelinating cells |
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| distribution of normal functioning of the axons |
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| name 3 pathogenesis of the PNS |
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Definition
myelinopathy axonopathy nerve cell body of a peripheral nerve |
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| A hereditary or inherited disorder in which the demyelinated axons are surrounded by Schwann cells that attempt to remyelinate but are unsuccessful. This process creates palpable, enlarged peripheral distal motor and sensory nerves |
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| Compression of the median nerve in the carpal tunnel |
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| Radiculopathy where the nerve root is affected |
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| Facial nerve is unilaterally affected |
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| Compression of brachial plexus/vascular |
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| Thoracic Outlet Syndrome (TOS) |
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| What can a PT do for PNS syndromes? |
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Definition
-Stretch tight postural ms -Strengthen scapular postural ms -R/O other possible conditions |
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| Name a metabolic neuropathy |
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Definition
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| A metabolic disturbance of nerve cells due to diabetes that results in possible demyelination; damage may also be caused by vascular changes. Manifests as sensory, motor, and proprioception deficits. Treat by controlling the diabetes. |
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Definition
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| A self-limiting, demyelinating syndrome related to autoimmune dysfunction, viral and bacterial infection, surgical complication, some vaccines, Hodgkin disease, and some types of drug reactions. Motor and/or sensory dysfunction begins in the extremities and moves proximally, sometimes leading to respiratory failure before function is restored within weeks or months |
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| An acute inflammatory demyelinating polyradiculoneuropathy that is an immune-mediated disorder. Results in antibody-mediated demyelination. manifests as both motor and sensory; distal to proximal. Treated via plasmapheresis and immunoglobulins |
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| 4 things PT does for Guillain-Barre |
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Definition
-Conservative exercise (fatigues easily) -Positioning -Wound Care -Respiratory Care |
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| A viral infection that can be transmitted via the fecal-oral route. The virus invades and damages motor neuron cell bodies located at anterior horn of spinal cord. |
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| Manifests as focal and asymmetric motor impairments including muscle weakness and often paralysis |
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| Preventable by immunization |
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| New neuromuscular symptoms that occur decades (25 yrs +) after recovery from the acute paralytic episode |
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| This dz is progressive; nonexhaustive exercise recommended; conditioning and assistive devices may be necesary |
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| A toxin that is ingested and poisons the CNS and PNS causing demyelination and manifests as motor weakness of mainly the UEs. Only treatment is to remove the toxin from the body |
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Definition
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| An autoimmune disorder where the ACh receptors are decreased at the NMJ by anti-ACh receptor antibodies. Manifests as motor weakness and fatigue. Treat by AChE inhibitors and thymus removal |
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Definition
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| May need to address all motor function with this dz such as movement, mobility, breathing, chewing, swallowing, etc |
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