Term
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Definition
oxidative - generate NADPH
non oxidative - interconversion of sugars |
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Term
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Definition
| need ribose-5-phosphate for DNA/RNA synth. no ATP, no NADPH, no NADH. 5 G6P + ATP -> 6 Ribose-5-P + ADP + H+ |
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Term
| mode 2: need NADPH and Ribose-5-P equally |
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Definition
| only use oxidative phase. G-6-P + H2O + 2 NADP+ -> Ribose-5-P + 2 NADPH + 2H+ + CO2. regulated by conc of NADP and NADPH |
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Term
| mode 3: need lots of NADPH, not Ribose-5-P |
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Definition
| PPP + gluconeogenesis. G-6-P + 12NADP + 7H2O -> 6CO2 + 12 NADPH + 12H+ + Pi. regulated by NADP levels. convert ribose-5-P by gluconeogenesis not glycolysis because of energy charge |
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Term
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Definition
| PPP + glycolysis. 3 G-6-P + 6 NADP+ + 5NAD+ + 5Pi + 8ADP -> 5 pyruvate + 3CO2+ 6NADPH + 5 NADH + 8ATP +2H2O + 8H+ |
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Term
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Definition
| fixes CO2, uses NADPH, C3 + C6 -> ribulose 1,5 BP |
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Term
| pentose phosphate pathway |
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Definition
| oxidizes sugars and generates CO2, makes NADPH, Ribose-5-P -> C3 + C6 |
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Term
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Definition
plants: split b/w cytosol & chloroplast
animals: cytosol |
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Term
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Definition
generates NADPH. regulated by NADP:NADPH ratio.
G-6-P DH rate limiting step. irreversible. high affinity for NADP over NAD. |
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Term
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Definition
| controlled by substrate/product ratios. transketolase and transaldolase |
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Term
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Definition
| transfer 2C glycoaldehyde from ketose to aldose. homologous to E1 subunit of pyruvate DH complex |
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Term
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Definition
| transfers 3C dihydroxylacetone group from ketose donor to aldose acceptor. homologous to enzyme-substrate intermediate formed in fructose 1,6-bisphosphate aldolase in glycolysis. |
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